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Q66JQ7

- CASC5_MOUSE

UniProt

Q66JQ7 - CASC5_MOUSE

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Protein

Protein CASC5

Gene

Casc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity).By similarity

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASC5
Alternative name(s):
Cancer susceptibility candidate gene 5 protein homolog
Kinetochore-null protein 1
Gene namesi
Name:Casc5
Synonyms:Knl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923714. Casc5.

Subcellular locationi

Nucleus By similarity. Chromosomecentromerekinetochore By similarity
Note: Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle (By similarity).By similarity

GO - Cellular componenti

  1. kinetochore Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16121612Protein CASC5PRO_0000235983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei60 – 601PhosphoserineBy similarity
Modified residuei794 – 7941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ66JQ7.
PaxDbiQ66JQ7.
PRIDEiQ66JQ7.

PTM databases

PhosphoSiteiQ66JQ7.

Expressioni

Gene expression databases

BgeeiQ66JQ7.
CleanExiMM_CASC5.
ExpressionAtlasiQ66JQ7. baseline and differential.
GenevestigatoriQ66JQ7.

Interactioni

Subunit structurei

Interacts with DSN1, MIS12, BUB1, BUB1B, NSL1 and ZWINT.By similarity

Protein-protein interaction databases

IntActiQ66JQ7. 10 interactions.
MINTiMINT-8174094.

Structurei

3D structure databases

ProteinModelPortaliQ66JQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati723 – 8271051Add
BLAST
Repeati923 – 10271052Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni723 – 10273052 X 104 AA approximate repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1577 – 159014Nuclear localization signalSequence AnalysisAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG116910.
GeneTreeiENSGT00410000025918.
HOGENOMiHOG000246954.
HOVERGENiHBG080986.
InParanoidiQ66JQ7.
OrthoDBiEOG7DNNV8.

Sequencei

Sequence statusi: Complete.

Q66JQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGVYSEANE ENDNTQRPVR RQHSSILKPP RSPLQDLKCG NQTNQEPNPP
60 70 80 90 100
RKRKSSRRVS FADTIKVFQT ESHMKTERNS EISGMNTLLC APIQTQMQQK
110 120 130 140 150
EFSITDCNHE RKHANDQTVI FSDENQMDLT ASHTVMITKG LSDCTKNENS
160 170 180 190 200
TKIDTTSFLE NLKHHAANSR IKKDLACSTV SLSQNIFSEK INSDNFIKRL
210 220 230 240 250
KTGKHISSST ELDKENAEIP VYSKDSNSAS STYQMHASLG VDENSSNRTR
260 270 280 290 300
IFREQDDGMN LTQCHTACIK TWIPPSTEAK IGEFKGDKTI YGNECMELTT
310 320 330 340 350
NYTIQVLSSE NNLSERETQT QNGMNVTTVD GATAPAPEKK TALKDKLNAA
360 370 380 390 400
FQGSFPNPEN KIHIIKCHPI ESETHTVTQI SSQSASTLAV TSKSICSSPA
410 420 430 440 450
IEGYKTIFHS SSNDAMELTK CLSAMEEEKK LLKADDKYSK ICTNPDAGPL
460 470 480 490 500
REKTIYLEED SMDITKSHTV AIDNKIFKHD QENIKKEIIA IPIFEKEMVL
510 520 530 540 550
RNLMPMSKDE KRDVNYISVP QVSKESLQRS QTNTLSVSLT DKKMEFLADE
560 570 580 590 600
DMDLTKSHTT KLSQVIPTTF DLASKNVTKS YSHSKSPLNE WESLDKQVVL
610 620 630 640 650
GQHSKLPLPQ RKDRDDPDCS HHKIMYSEEL QTMDLTKSHT IVIGFGPSEV
660 670 680 690 700
QEHSKINLEH KNSQLTAESI QTAVNVPAAN SRVVTTNDMD MLKDRSTHKP
710 720 730 740 750
ELLKEKQNIK IYGRKSIGRL KIDKTILFSE GNEGDMDITK SCTVKINHRS
760 770 780 790 800
LLDKHDSHLV SLAGTSKTIL HARGQVEMEI NRSHTTPLEC KIISPSDITP
810 820 830 840 850
GDLDKTMMSI DDHEELDMTK SHTVFIDYQA EAKGVLPDRL DFQLSKKESL
860 870 880 890 900
QKPKVTSLAE EIYISKNSES NHLPAKGSQL TILEEGSNSG LGEETNDAQK
910 920 930 940 950
PGFLNELLSG KTQRRKSLSL KNKSITFPEN DKSYREIPQS SAVEINNETR
960 970 980 990 1000
LEDRKGFSFV PLAGTSKPVL SAYGPEDMEI SIGQTTASEY KTVPPEEITT
1010 1020 1030 1040 1050
IPMDKTVMFV DNFGDLDVTR SHTVFIDCQA KEKVLDEYTN LGIQKTKTLS
1060 1070 1080 1090 1100
GSEGDTHIQE ITKNPAAQHK HHMTTVIPSS TVVSDQSSMK IKFHKADRDE
1110 1120 1130 1140 1150
EVKGKEVEAN MLKQTKPESC LLNITDGKNV DFTSSYTADV CRSSDKYSSL
1160 1170 1180 1190 1200
PNISSSDNSG GNTMSLCDKN KEKAYNCQVP NEFTYAAILP STYHMDSKKL
1210 1220 1230 1240 1250
SVFPPCPSKE VTQTESAIAL LKDEDPVEEP LGEMATFNSK HVSLNLAKDQ
1260 1270 1280 1290 1300
TEAFVDVSVA SQPHLSAQQS PSTQKGQDVA RRDEGILAKA GKKALPFLLE
1310 1320 1330 1340 1350
NVAASTWENE SKIPTNVEHF AVTYEKELSI SIQTDKCNTN VQSPSNSALT
1360 1370 1380 1390 1400
TQVIQTHANA EGALDFLVPS TVSCFSSTKP SLSNLNRKTE EVLDFQTVNL
1410 1420 1430 1440 1450
LPPAEQLLEE GSQAHSMSIV QATEIYRLGS RNDRDEESKT FCNEAETTSV
1460 1470 1480 1490 1500
PLKTAVKDKT RRCSLGIFLP KLPSKRSCSI TGVDDLEQIL ADAADLTQLE
1510 1520 1530 1540 1550
TQPVCSKDPG IGSVAAKLNL SPSQFINEEN LPVYPGEILS SDSVSLDIEE
1560 1570 1580 1590 1600
SVLIDTSQRE SLPSENKTEN CRAQKRTRVE ENDVTNEKKI RTHDSAQDQE
1610
VSCLEPKNVL EF
Length:1,612
Mass (Da):179,337
Last modified:July 27, 2011 - v3
Checksum:iA9BE2BB20E008621
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281D → G in AAH80815. (PubMed:15489334)Curated
Sequence conflicti375 – 3751H → R in AAH80815. (PubMed:15489334)Curated
Sequence conflicti1151 – 11511P → L in AAH80815. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA. Translation: CAM45955.1.
BC080815 mRNA. Translation: AAH80815.1.
AK009772 mRNA. Translation: BAB26494.1.
AK033132 mRNA. Translation: BAC28167.2.
UniGeneiMm.202518.
Mm.392877.

Genome annotation databases

EnsembliENSMUST00000028799; ENSMUSP00000028799; ENSMUSG00000027326.
UCSCiuc008ltb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA. Translation: CAM45955.1 .
BC080815 mRNA. Translation: AAH80815.1 .
AK009772 mRNA. Translation: BAB26494.1 .
AK033132 mRNA. Translation: BAC28167.2 .
UniGenei Mm.202518.
Mm.392877.

3D structure databases

ProteinModelPortali Q66JQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q66JQ7. 10 interactions.
MINTi MINT-8174094.

PTM databases

PhosphoSitei Q66JQ7.

Proteomic databases

MaxQBi Q66JQ7.
PaxDbi Q66JQ7.
PRIDEi Q66JQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028799 ; ENSMUSP00000028799 ; ENSMUSG00000027326 .
UCSCi uc008ltb.1. mouse.

Organism-specific databases

MGIi MGI:1923714. Casc5.

Phylogenomic databases

eggNOGi NOG116910.
GeneTreei ENSGT00410000025918.
HOGENOMi HOG000246954.
HOVERGENi HBG080986.
InParanoidi Q66JQ7.
OrthoDBi EOG7DNNV8.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

PROi Q66JQ7.
SOURCEi Search...

Gene expression databases

Bgeei Q66JQ7.
CleanExi MM_CASC5.
ExpressionAtlasi Q66JQ7. baseline and differential.
Genevestigatori Q66JQ7.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic germ cell.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-507.
    Strain: C57BL/6J.
    Tissue: Testis and Tongue.

Entry informationi

Entry nameiCASC5_MOUSE
AccessioniPrimary (citable) accession number: Q66JQ7
Secondary accession number(s): A3KGI4, Q8CCH6, Q9CV38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3