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Q66JQ7

- CASC5_MOUSE

UniProt

Q66JQ7 - CASC5_MOUSE

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Protein

Protein CASC5

Gene
Casc5, Knl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore By similarity.

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASC5
Alternative name(s):
Cancer susceptibility candidate gene 5 protein homolog
Kinetochore-null protein 1
Gene namesi
Name:Casc5
Synonyms:Knl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923714. Casc5.

Subcellular locationi

Nucleus By similarity. Chromosomecentromerekinetochore By similarity
Note: Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle By similarity.

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16121612Protein CASC5PRO_0000235983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321Phosphoserine By similarity
Modified residuei60 – 601Phosphoserine By similarity
Modified residuei794 – 7941Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66JQ7.
PRIDEiQ66JQ7.

PTM databases

PhosphoSiteiQ66JQ7.

Expressioni

Gene expression databases

ArrayExpressiQ66JQ7.
BgeeiQ66JQ7.
CleanExiMM_CASC5.
GenevestigatoriQ66JQ7.

Interactioni

Subunit structurei

Interacts with DSN1, MIS12, BUB1, BUB1B, NSL1 and ZWINT By similarity.

Protein-protein interaction databases

IntActiQ66JQ7. 10 interactions.
MINTiMINT-8174094.

Structurei

3D structure databases

ProteinModelPortaliQ66JQ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati723 – 8271051Add
BLAST
Repeati923 – 10271052Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni723 – 10273052 X 104 AA approximate repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1577 – 159014Nuclear localization signal Reviewed predictionAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG116910.
GeneTreeiENSGT00410000025918.
HOGENOMiHOG000246954.
HOVERGENiHBG080986.
OrthoDBiEOG7DNNV8.

Sequencei

Sequence statusi: Complete.

Q66JQ7-1 [UniParc]FASTAAdd to Basket

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MDGVYSEANE ENDNTQRPVR RQHSSILKPP RSPLQDLKCG NQTNQEPNPP     50
RKRKSSRRVS FADTIKVFQT ESHMKTERNS EISGMNTLLC APIQTQMQQK 100
EFSITDCNHE RKHANDQTVI FSDENQMDLT ASHTVMITKG LSDCTKNENS 150
TKIDTTSFLE NLKHHAANSR IKKDLACSTV SLSQNIFSEK INSDNFIKRL 200
KTGKHISSST ELDKENAEIP VYSKDSNSAS STYQMHASLG VDENSSNRTR 250
IFREQDDGMN LTQCHTACIK TWIPPSTEAK IGEFKGDKTI YGNECMELTT 300
NYTIQVLSSE NNLSERETQT QNGMNVTTVD GATAPAPEKK TALKDKLNAA 350
FQGSFPNPEN KIHIIKCHPI ESETHTVTQI SSQSASTLAV TSKSICSSPA 400
IEGYKTIFHS SSNDAMELTK CLSAMEEEKK LLKADDKYSK ICTNPDAGPL 450
REKTIYLEED SMDITKSHTV AIDNKIFKHD QENIKKEIIA IPIFEKEMVL 500
RNLMPMSKDE KRDVNYISVP QVSKESLQRS QTNTLSVSLT DKKMEFLADE 550
DMDLTKSHTT KLSQVIPTTF DLASKNVTKS YSHSKSPLNE WESLDKQVVL 600
GQHSKLPLPQ RKDRDDPDCS HHKIMYSEEL QTMDLTKSHT IVIGFGPSEV 650
QEHSKINLEH KNSQLTAESI QTAVNVPAAN SRVVTTNDMD MLKDRSTHKP 700
ELLKEKQNIK IYGRKSIGRL KIDKTILFSE GNEGDMDITK SCTVKINHRS 750
LLDKHDSHLV SLAGTSKTIL HARGQVEMEI NRSHTTPLEC KIISPSDITP 800
GDLDKTMMSI DDHEELDMTK SHTVFIDYQA EAKGVLPDRL DFQLSKKESL 850
QKPKVTSLAE EIYISKNSES NHLPAKGSQL TILEEGSNSG LGEETNDAQK 900
PGFLNELLSG KTQRRKSLSL KNKSITFPEN DKSYREIPQS SAVEINNETR 950
LEDRKGFSFV PLAGTSKPVL SAYGPEDMEI SIGQTTASEY KTVPPEEITT 1000
IPMDKTVMFV DNFGDLDVTR SHTVFIDCQA KEKVLDEYTN LGIQKTKTLS 1050
GSEGDTHIQE ITKNPAAQHK HHMTTVIPSS TVVSDQSSMK IKFHKADRDE 1100
EVKGKEVEAN MLKQTKPESC LLNITDGKNV DFTSSYTADV CRSSDKYSSL 1150
PNISSSDNSG GNTMSLCDKN KEKAYNCQVP NEFTYAAILP STYHMDSKKL 1200
SVFPPCPSKE VTQTESAIAL LKDEDPVEEP LGEMATFNSK HVSLNLAKDQ 1250
TEAFVDVSVA SQPHLSAQQS PSTQKGQDVA RRDEGILAKA GKKALPFLLE 1300
NVAASTWENE SKIPTNVEHF AVTYEKELSI SIQTDKCNTN VQSPSNSALT 1350
TQVIQTHANA EGALDFLVPS TVSCFSSTKP SLSNLNRKTE EVLDFQTVNL 1400
LPPAEQLLEE GSQAHSMSIV QATEIYRLGS RNDRDEESKT FCNEAETTSV 1450
PLKTAVKDKT RRCSLGIFLP KLPSKRSCSI TGVDDLEQIL ADAADLTQLE 1500
TQPVCSKDPG IGSVAAKLNL SPSQFINEEN LPVYPGEILS SDSVSLDIEE 1550
SVLIDTSQRE SLPSENKTEN CRAQKRTRVE ENDVTNEKKI RTHDSAQDQE 1600
VSCLEPKNVL EF 1612
Length:1,612
Mass (Da):179,337
Last modified:July 27, 2011 - v3
Checksum:iA9BE2BB20E008621
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281D → G in AAH80815. 1 Publication
Sequence conflicti375 – 3751H → R in AAH80815. 1 Publication
Sequence conflicti1151 – 11511P → L in AAH80815. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772264 Genomic DNA. Translation: CAM45955.1.
BC080815 mRNA. Translation: AAH80815.1.
AK009772 mRNA. Translation: BAB26494.1.
AK033132 mRNA. Translation: BAC28167.2.
UniGeneiMm.202518.
Mm.392877.

Genome annotation databases

EnsembliENSMUST00000028799; ENSMUSP00000028799; ENSMUSG00000027326.
UCSCiuc008ltb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772264 Genomic DNA. Translation: CAM45955.1 .
BC080815 mRNA. Translation: AAH80815.1 .
AK009772 mRNA. Translation: BAB26494.1 .
AK033132 mRNA. Translation: BAC28167.2 .
UniGenei Mm.202518.
Mm.392877.

3D structure databases

ProteinModelPortali Q66JQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q66JQ7. 10 interactions.
MINTi MINT-8174094.

PTM databases

PhosphoSitei Q66JQ7.

Proteomic databases

PaxDbi Q66JQ7.
PRIDEi Q66JQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028799 ; ENSMUSP00000028799 ; ENSMUSG00000027326 .
UCSCi uc008ltb.1. mouse.

Organism-specific databases

MGIi MGI:1923714. Casc5.

Phylogenomic databases

eggNOGi NOG116910.
GeneTreei ENSGT00410000025918.
HOGENOMi HOG000246954.
HOVERGENi HBG080986.
OrthoDBi EOG7DNNV8.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

PROi Q66JQ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q66JQ7.
Bgeei Q66JQ7.
CleanExi MM_CASC5.
Genevestigatori Q66JQ7.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic germ cell.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-507.
    Strain: C57BL/6J.
    Tissue: Testis and Tongue.

Entry informationi

Entry nameiCASC5_MOUSE
AccessioniPrimary (citable) accession number: Q66JQ7
Secondary accession number(s): A3KGI4, Q8CCH6, Q9CV38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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