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Protein

Sprouty-related, EVH1 domain-containing protein 1

Gene

spred1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 1
Short name:
Spred-1
Gene namesi
Name:spred1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-482851. spred1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769091 – 406Sprouty-related, EVH1 domain-containing protein 1Add BLAST406

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Ras.By similarity

GO - Molecular functioni

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 21Combined sources10
Beta strandi23 – 26Combined sources4
Beta strandi28 – 30Combined sources3
Helixi31 – 33Combined sources3
Beta strandi37 – 42Combined sources6
Beta strandi56 – 61Combined sources6
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi78 – 83Combined sources6
Beta strandi86 – 91Combined sources6
Beta strandi94 – 102Combined sources9
Helixi103 – 120Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJ6X-ray1.65A/B8-123[»]
1XODX-ray1.15A/B8-123[»]
ProteinModelPortaliQ66JG9.
SMRiQ66JG9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ66JG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 120WH1PROSITE-ProRule annotationAdd BLAST118
Domaini195 – 247KBDPROSITE-ProRule annotationAdd BLAST53
Domaini296 – 404SPRPROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Gly4

Sequence similaritiesi

Contains 1 KBD domain.PROSITE-ProRule annotation
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
Contains 1 WH1 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ66JG9.
KOiK04703.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_dom-like.
IPR007875. Sprouty.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66JG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEQEPDDS YARVRAVVMT RDDSSGGWLQ LGGGGLSSVT VSKTLQPGDS
60 70 80 90 100
GGTEFLVHGE RLRDKTVVLE CVLRRDLVYN KVTPTFHHWR IGDKKFGLTF
110 120 130 140 150
QSPADARAFD RGIRRAIEDL SQGLPASCHG ESETSEDGPQ VNKEDHYSTH
160 170 180 190 200
NNDHFFRSDS IPTEELYRTS VIRPSPFENL NPRRAYIHNQ VPLKPIRHVS
210 220 230 240 250
FQDEDEIVRI NPRDMIIRRY ADYRHPDIFR NDVDREEPED VTFFTKTDSK
260 270 280 290 300
KPSYLYSPAN GRDSLKEQKP VEVCKIQPTS SLKKSKGKKE DGEHSSCVYC
310 320 330 340 350
QERFNHEENG RGKCQDAPDP IQRCIYQVSC MLCAESMLYH CMSDSEGDYS
360 370 380 390 400
DPCSCDASDE NLCLRWLALI TLSFIAPCMC CYLPLRACHH CGEMCGCCGG

KHKAAG
Length:406
Mass (Da):45,905
Last modified:October 11, 2004 - v1
Checksum:i417041C1CFF32CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY714338 mRNA. Translation: AAU43767.1.
BC080919 mRNA. Translation: AAH80919.1.
RefSeqiNP_001008037.1. NM_001008036.1.
UniGeneiStr.3321.

Genome annotation databases

GeneIDi493399.
KEGGixtr:493399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY714338 mRNA. Translation: AAU43767.1.
BC080919 mRNA. Translation: AAH80919.1.
RefSeqiNP_001008037.1. NM_001008036.1.
UniGeneiStr.3321.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJ6X-ray1.65A/B8-123[»]
1XODX-ray1.15A/B8-123[»]
ProteinModelPortaliQ66JG9.
SMRiQ66JG9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493399.
KEGGixtr:493399.

Organism-specific databases

CTDi161742.
XenbaseiXB-GENE-482851. spred1.

Phylogenomic databases

HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ66JG9.
KOiK04703.

Miscellaneous databases

EvolutionaryTraceiQ66JG9.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_dom-like.
IPR007875. Sprouty.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPRE1_XENTR
AccessioniPrimary (citable) accession number: Q66JG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.