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Protein

Sprouty-related, EVH1 domain-containing protein 1

Gene

spred1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 1
Short name:
Spred-1
Gene namesi
Name:spred1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-482851 spred1

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769091 – 406Sprouty-related, EVH1 domain-containing protein 1Add BLAST406

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Ras.By similarity

GO - Molecular functioni

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 21Combined sources10
Beta strandi23 – 26Combined sources4
Beta strandi28 – 30Combined sources3
Helixi31 – 33Combined sources3
Beta strandi37 – 42Combined sources6
Beta strandi56 – 61Combined sources6
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi78 – 83Combined sources6
Beta strandi86 – 91Combined sources6
Beta strandi94 – 102Combined sources9
Helixi103 – 120Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TJ6X-ray1.65A/B8-123[»]
1XODX-ray1.15A/B8-123[»]
ProteinModelPortaliQ66JG9
SMRiQ66JG9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ66JG9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 120WH1PROSITE-ProRule annotationAdd BLAST118
Domaini195 – 247KBDPROSITE-ProRule annotationAdd BLAST53
Domaini296 – 404SPRPROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Gly4

Phylogenomic databases

HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ66JG9
KOiK04703

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequencei

Sequence statusi: Complete.

Q66JG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEQEPDDS YARVRAVVMT RDDSSGGWLQ LGGGGLSSVT VSKTLQPGDS
60 70 80 90 100
GGTEFLVHGE RLRDKTVVLE CVLRRDLVYN KVTPTFHHWR IGDKKFGLTF
110 120 130 140 150
QSPADARAFD RGIRRAIEDL SQGLPASCHG ESETSEDGPQ VNKEDHYSTH
160 170 180 190 200
NNDHFFRSDS IPTEELYRTS VIRPSPFENL NPRRAYIHNQ VPLKPIRHVS
210 220 230 240 250
FQDEDEIVRI NPRDMIIRRY ADYRHPDIFR NDVDREEPED VTFFTKTDSK
260 270 280 290 300
KPSYLYSPAN GRDSLKEQKP VEVCKIQPTS SLKKSKGKKE DGEHSSCVYC
310 320 330 340 350
QERFNHEENG RGKCQDAPDP IQRCIYQVSC MLCAESMLYH CMSDSEGDYS
360 370 380 390 400
DPCSCDASDE NLCLRWLALI TLSFIAPCMC CYLPLRACHH CGEMCGCCGG

KHKAAG
Length:406
Mass (Da):45,905
Last modified:October 11, 2004 - v1
Checksum:i417041C1CFF32CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY714338 mRNA Translation: AAU43767.1
BC080919 mRNA Translation: AAH80919.1
RefSeqiNP_001008037.1, NM_001008036.1
UniGeneiStr.3321

Genome annotation databases

GeneIDi493399
KEGGixtr:493399

Similar proteinsi

Entry informationi

Entry nameiSPRE1_XENTR
AccessioniPrimary (citable) accession number: Q66JG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health