Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q66JB6

- BAP1_XENTR

UniProt

Q66JB6 - BAP1_XENTR

Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

bap1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911NucleophileBy similarity
    Active sitei169 – 1691Proton donorBy similarity
    Sitei184 – 1841Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. protein K48-linked deubiquitination Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell growth Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
    Alternative name(s):
    BRCA1-associated protein 1
    Gene namesi
    Name:bap1
    ORF Names:TEgg031c22.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-494978. bap1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly nuclear. Binds to chromatin By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 685685Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395821Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000000167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66JB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG249036.
    HOGENOMiHOG000013189.
    HOVERGENiHBG054042.
    InParanoidiQ66JB6.
    KOiK08588.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    Q66JB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF    50
    KWIEERRSRR KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL 100
    LNCSGVHLGP TLSRIKEFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR 150
    HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWAEDE 200
    EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK YESKLHILKM 250
    NRQTVLEALQ QLIRVTQPEL IQAQKPTEGQ STEETKSAAL KAPVSQESHR 300
    AHHGSHRNAT DVGAEPPGAL IRGPVMSAYS KPNSLAQNGG TVAAPASRLP 350
    AFLDNHNYAK SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP 400
    LTPPGFKRRS SEPLPPPPGP EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP 450
    HSQPSPTPSN ESTDTASEIG SAFNSPLRSP LRSANPTRPS SPVTLHLSKV 500
    LFGEEEPLLR LDCVRYNRAV RELGPHISTG ILHLSKDGYL CPLSRLETGK 550
    VSPKGNKVEE PRESSEPDTE RSRVTEVPQG EKFSPKELLA LLKCVEAEIS 600
    SSEACLREEL EKRKKFKIDD QRRTHNYDEF ICAFISMLAQ EGMLASLVEQ 650
    NISVRRRQGV SIGRLHKQRK PDRRKRSRPY KAKRQ 685
    Length:685
    Mass (Da):76,399
    Last modified:October 11, 2004 - v1
    Checksum:i7A96F850498495FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti308 – 3081N → S in CAJ81966. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848566 mRNA. Translation: CAJ81966.1.
    BC080985 mRNA. Translation: AAH80985.1.
    RefSeqiNP_001008206.1. NM_001008205.1.
    UniGeneiStr.10136.

    Genome annotation databases

    GeneIDi493568.
    KEGGixtr:493568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848566 mRNA. Translation: CAJ81966.1 .
    BC080985 mRNA. Translation: AAH80985.1 .
    RefSeqi NP_001008206.1. NM_001008205.1.
    UniGenei Str.10136.

    3D structure databases

    ProteinModelPortali Q66JB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000000167.

    Protein family/group databases

    MEROPSi C12.004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493568.
    KEGGi xtr:493568.

    Organism-specific databases

    CTDi 8314.
    Xenbasei XB-GENE-494978. bap1.

    Phylogenomic databases

    eggNOGi NOG249036.
    HOGENOMi HOG000013189.
    HOVERGENi HBG054042.
    InParanoidi Q66JB6.
    KOi K08588.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiBAP1_XENTR
    AccessioniPrimary (citable) accession number: Q66JB6
    Secondary accession number(s): Q28DW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3