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Q66JB6 (BAP1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1
EC=3.4.19.12
Alternative name(s):
BRCA1-associated protein 1
Gene names
Name:bap1
ORF Names:TEgg031c22.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length685 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 685685Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395821

Sites

Active site911Nucleophile By similarity
Active site1691Proton donor By similarity
Site1841Important for enzyme activity By similarity

Experimental info

Sequence conflict3081N → S in CAJ81966. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q66JB6 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 7A96F850498495FA

FASTA68576,399
        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF KWIEERRSRR 

        70         80         90        100        110        120 
KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL LNCSGVHLGP TLSRIKEFTK 

       130        140        150        160        170        180 
GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL 

       190        200        210        220        230        240 
FELDGLKVYP IDHGPWAEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK 

       250        260        270        280        290        300 
YESKLHILKM NRQTVLEALQ QLIRVTQPEL IQAQKPTEGQ STEETKSAAL KAPVSQESHR 

       310        320        330        340        350        360 
AHHGSHRNAT DVGAEPPGAL IRGPVMSAYS KPNSLAQNGG TVAAPASRLP AFLDNHNYAK 

       370        380        390        400        410        420 
SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP LTPPGFKRRS SEPLPPPPGP 

       430        440        450        460        470        480 
EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP HSQPSPTPSN ESTDTASEIG SAFNSPLRSP 

       490        500        510        520        530        540 
LRSANPTRPS SPVTLHLSKV LFGEEEPLLR LDCVRYNRAV RELGPHISTG ILHLSKDGYL 

       550        560        570        580        590        600 
CPLSRLETGK VSPKGNKVEE PRESSEPDTE RSRVTEVPQG EKFSPKELLA LLKCVEAEIS 

       610        620        630        640        650        660 
SSEACLREEL EKRKKFKIDD QRRTHNYDEF ICAFISMLAQ EGMLASLVEQ NISVRRRQGV 

       670        680 
SIGRLHKQRK PDRRKRSRPY KAKRQ

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848566 mRNA. Translation: CAJ81966.1.
BC080985 mRNA. Translation: AAH80985.1.
RefSeqNP_001008206.1. NM_001008205.1.
UniGeneStr.10136.

3D structure databases

ProteinModelPortalQ66JB6.
ModBaseSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000000167.

Protein family/group databases

MEROPSC12.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493568.
KEGGxtr:493568.

Organism-specific databases

CTD8314.
XenbaseXB-GENE-494978. bap1.

Phylogenomic databases

eggNOGNOG249036.
HOGENOMHOG000013189.
HOVERGENHBG054042.
InParanoidQ66JB6.
KOK08588.
OrthoDBEOG4XPQFC.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
PROSITEPS00140. UCH_1. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBAP1_XENTR
AccessionPrimary (citable) accession number: Q66JB6
Secondary accession number(s): Q28DW6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 11, 2004
Last modified: April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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