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Q66JB6

- BAP1_XENTR

UniProt

Q66JB6 - BAP1_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

bap1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911NucleophileBy similarity
Active sitei169 – 1691Proton donorBy similarity
Sitei184 – 1841Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. protein K48-linked deubiquitination Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell growth Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
Alternative name(s):
BRCA1-associated protein 1
Gene namesi
Name:bap1
ORF Names:TEgg031c22.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-494978. bap1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly nuclear. Binds to chromatin (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395821Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000167.

Structurei

3D structure databases

ProteinModelPortaliQ66JB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000013189.
HOVERGENiHBG054042.
InParanoidiQ66JB6.
KOiK08588.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q66JB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF
60 70 80 90 100
KWIEERRSRR KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL
110 120 130 140 150
LNCSGVHLGP TLSRIKEFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR
160 170 180 190 200
HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWAEDE
210 220 230 240 250
EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK YESKLHILKM
260 270 280 290 300
NRQTVLEALQ QLIRVTQPEL IQAQKPTEGQ STEETKSAAL KAPVSQESHR
310 320 330 340 350
AHHGSHRNAT DVGAEPPGAL IRGPVMSAYS KPNSLAQNGG TVAAPASRLP
360 370 380 390 400
AFLDNHNYAK SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP
410 420 430 440 450
LTPPGFKRRS SEPLPPPPGP EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP
460 470 480 490 500
HSQPSPTPSN ESTDTASEIG SAFNSPLRSP LRSANPTRPS SPVTLHLSKV
510 520 530 540 550
LFGEEEPLLR LDCVRYNRAV RELGPHISTG ILHLSKDGYL CPLSRLETGK
560 570 580 590 600
VSPKGNKVEE PRESSEPDTE RSRVTEVPQG EKFSPKELLA LLKCVEAEIS
610 620 630 640 650
SSEACLREEL EKRKKFKIDD QRRTHNYDEF ICAFISMLAQ EGMLASLVEQ
660 670 680
NISVRRRQGV SIGRLHKQRK PDRRKRSRPY KAKRQ
Length:685
Mass (Da):76,399
Last modified:October 11, 2004 - v1
Checksum:i7A96F850498495FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti308 – 3081N → S in CAJ81966. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848566 mRNA. Translation: CAJ81966.1.
BC080985 mRNA. Translation: AAH80985.1.
RefSeqiNP_001008206.1. NM_001008205.1.
UniGeneiStr.10136.

Genome annotation databases

GeneIDi493568.
KEGGixtr:493568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848566 mRNA. Translation: CAJ81966.1 .
BC080985 mRNA. Translation: AAH80985.1 .
RefSeqi NP_001008206.1. NM_001008205.1.
UniGenei Str.10136.

3D structure databases

ProteinModelPortali Q66JB6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000000167.

Protein family/group databases

MEROPSi C12.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493568.
KEGGi xtr:493568.

Organism-specific databases

CTDi 8314.
Xenbasei XB-GENE-494978. bap1.

Phylogenomic databases

eggNOGi NOG249036.
HOGENOMi HOG000013189.
HOVERGENi HBG054042.
InParanoidi Q66JB6.
KOi K08588.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiBAP1_XENTR
AccessioniPrimary (citable) accession number: Q66JB6
Secondary accession number(s): Q28DW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3