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Protein

Enhancer of polycomb homolog 2

Gene

epc2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in transcription or DNA repair.By similarity

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of polycomb homolog 2
Gene namesi
Name:epc2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866062 epc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392971 – 804Enhancer of polycomb homolog 2Add BLAST804

Interactioni

Protein-protein interaction databases

BioGridi104293, 1 interactor

Structurei

3D structure databases

SMRiQ66JA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi486 – 489Poly-Ser4
Compositional biasi579 – 616Gln-richAdd BLAST38

Sequence similaritiesi

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

HOVERGENiHBG051489
KOiK11322

Family and domain databases

InterProiView protein in InterPro
IPR024943 Enhancer_polycomb
IPR019542 Enhancer_polycomb-like_N
IPR009607 Enhancer_polycomb_C
PANTHERiPTHR14898 PTHR14898, 1 hit
PfamiView protein in Pfam
PF06752 E_Pc_C, 1 hit
PF10513 EPL1, 1 hit

Sequencei

Sequence statusi: Complete.

Q66JA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSFRARA LDATKPLPIF RGNDMPDLND CVSINRAVPQ MPTGMEKEEE
60 70 80 90 100
SEHHLQRAIS AQQVFREKKE CMVIPVPEAE SNVHYYSRLY KGEFKQPKQF
110 120 130 140 150
IHITPFNLDY EQPDYDMDSE DETLLNRLNR KMEIKPLQFE IMIDRLEKAS
160 170 180 190 200
SNQLVSLQEA KLLLNEDDYL IKSVYDYWVR KRKNCRGPCL IPQVKQEKRD
210 220 230 240 250
GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE FSRAITILEM
260 270 280 290 300
IKRREKTKRE LLHLTLEVVE KRYNLGDFGG EILNEIKIPK ADKEIYAIPP
310 320 330 340 350
SLHNGNHHKV PECKVKNTHH LNVKDEVLEI VRLKKKYPKK PKADILVTPL
360 370 380 390 400
PQANSEPLAV INRSDIKQYD FQSSDDDEFP QVPSPLSELE EENDPDGSYA
410 420 430 440 450
FRRRAGCQYY APHLDQMNDT PETTDLSGLA RHRNRHCLTT LTVPRRCIGF
460 470 480 490 500
ARKRLGRGGR VIMDRLSTEH DSVLKQIDPE MLSGFSSSSH IAQPPSSPSR
510 520 530 540 550
TNASDRHCEN RLSLPEILSN IKSCRLQCFQ PRLLHTQDSD REECTSRLGQ
560 570 580 590 600
AVNLKRVSSS LLNTSKNGIT VTGGITEEQF QTHQQQLVQM QKQQLAQLQQ
610 620 630 640 650
KQQSQQSLQQ SHPKAQGSGS SDCMSKTLDS ASALFAASAV VNSPAPVRSE
660 670 680 690 700
VNKDQNAGHS NLNGVVQPSG TAKTLYSTNM ALSSSPGIST VQLVRTVGHP
710 720 730 740 750
TTNHLIPTLC TSNPQTLTMG NSCLANTVHL NNVSVVSPVN VHLNTRTSAP
760 770 780 790 800
SPTALKLATV AASMDRVPKV TPSSAMSSIA RENHEPERLG LNGITDTTVA

MEVT
Length:804
Mass (Da):90,649
Last modified:October 11, 2004 - v1
Checksum:iF4335E7A02CCEF7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080994 mRNA Translation: AAH80994.1
RefSeqiNP_001087609.1, NM_001094140.1
UniGeneiXl.45068

Genome annotation databases

GeneIDi447433
KEGGixla:447433

Similar proteinsi

Entry informationi

Entry nameiEPC2_XENLA
AccessioniPrimary (citable) accession number: Q66JA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health