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Protein

Enhancer of polycomb homolog 2

Gene

epc2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in transcription or DNA repair.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of polycomb homolog 2
Gene namesi
Name:epc2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866062. epc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Enhancer of polycomb homolog 2PRO_0000239297Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi104293. 1 interaction.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 4894Poly-Ser
Compositional biasi579 – 61638Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

HOVERGENiHBG051489.
KOiK11322.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66JA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSFRARA LDATKPLPIF RGNDMPDLND CVSINRAVPQ MPTGMEKEEE
60 70 80 90 100
SEHHLQRAIS AQQVFREKKE CMVIPVPEAE SNVHYYSRLY KGEFKQPKQF
110 120 130 140 150
IHITPFNLDY EQPDYDMDSE DETLLNRLNR KMEIKPLQFE IMIDRLEKAS
160 170 180 190 200
SNQLVSLQEA KLLLNEDDYL IKSVYDYWVR KRKNCRGPCL IPQVKQEKRD
210 220 230 240 250
GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE FSRAITILEM
260 270 280 290 300
IKRREKTKRE LLHLTLEVVE KRYNLGDFGG EILNEIKIPK ADKEIYAIPP
310 320 330 340 350
SLHNGNHHKV PECKVKNTHH LNVKDEVLEI VRLKKKYPKK PKADILVTPL
360 370 380 390 400
PQANSEPLAV INRSDIKQYD FQSSDDDEFP QVPSPLSELE EENDPDGSYA
410 420 430 440 450
FRRRAGCQYY APHLDQMNDT PETTDLSGLA RHRNRHCLTT LTVPRRCIGF
460 470 480 490 500
ARKRLGRGGR VIMDRLSTEH DSVLKQIDPE MLSGFSSSSH IAQPPSSPSR
510 520 530 540 550
TNASDRHCEN RLSLPEILSN IKSCRLQCFQ PRLLHTQDSD REECTSRLGQ
560 570 580 590 600
AVNLKRVSSS LLNTSKNGIT VTGGITEEQF QTHQQQLVQM QKQQLAQLQQ
610 620 630 640 650
KQQSQQSLQQ SHPKAQGSGS SDCMSKTLDS ASALFAASAV VNSPAPVRSE
660 670 680 690 700
VNKDQNAGHS NLNGVVQPSG TAKTLYSTNM ALSSSPGIST VQLVRTVGHP
710 720 730 740 750
TTNHLIPTLC TSNPQTLTMG NSCLANTVHL NNVSVVSPVN VHLNTRTSAP
760 770 780 790 800
SPTALKLATV AASMDRVPKV TPSSAMSSIA RENHEPERLG LNGITDTTVA

MEVT
Length:804
Mass (Da):90,649
Last modified:October 11, 2004 - v1
Checksum:iF4335E7A02CCEF7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080994 mRNA. Translation: AAH80994.1.
RefSeqiNP_001087609.1. NM_001094140.1.
UniGeneiXl.45068.

Genome annotation databases

GeneIDi447433.
KEGGixla:447433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080994 mRNA. Translation: AAH80994.1.
RefSeqiNP_001087609.1. NM_001094140.1.
UniGeneiXl.45068.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi104293. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447433.
KEGGixla:447433.

Organism-specific databases

CTDi26122.
XenbaseiXB-GENE-866062. epc2.

Phylogenomic databases

HOVERGENiHBG051489.
KOiK11322.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPC2_XENLA
AccessioniPrimary (citable) accession number: Q66JA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.