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Protein

Insulin-induced gene 2 protein

Gene

insig2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates feedback control of cholesterol synthesis.By similarity

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-induced gene 2 protein
Short name:
INSIG-2
Gene namesi
Name:insig2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5777147. insig2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868031 – 218Insulin-induced gene 2 proteinAdd BLAST218

Structurei

3D structure databases

ProteinModelPortaliQ66J27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the INSIG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG058958.

Family and domain databases

InterProiView protein in InterPro
IPR025929. INSIG_fam.
PANTHERiPTHR15301. PTHR15301. 1 hit.
PfamiView protein in Pfam
PF07281. INSIG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66J27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRENVSYG SRPILAQKMN LLLRGFLLFL IGVFLALVLN LLQVQRNVTL
60 70 80 90 100
FPPDVLSSLF SSAWWVPLCC GTAAAAIGLL YPCIDRHLGE PHKFKREWSS
110 120 130 140 150
VMRCVAVFVG INHASAKVDF ANNMQLSLTL AALSIGLWWT FDRSRSGLGL
160 170 180 190 200
GIGISFFATL VSQLLVYNGV YEYTAPDFLY VRSWLPCIFF AGGITMGNIG
210
RQLEMYERKA LVEKSHRD
Length:218
Mass (Da):24,359
Last modified:October 11, 2004 - v1
Checksum:i2314F9647A138280
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081084 mRNA. Translation: AAH81084.1.
RefSeqiNP_001087688.1. NM_001094219.1.
XP_018089979.1. XM_018234490.1.
UniGeneiXl.48844.

Genome annotation databases

GeneIDi447512.
KEGGixla:447512.

Similar proteinsi

Entry informationi

Entry nameiINSI2_XENLA
AccessioniPrimary (citable) accession number: Q66J27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families