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Protein

Trans-L-3-hydroxyproline dehydratase

Gene

l3hypdh

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).By similarity

Catalytic activityi

Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011Proton acceptorBy similarity
Binding sitei263 – 2631SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-L-3-hydroxyproline dehydratase (EC:4.2.1.77)
Alternative name(s):
Trans-3-hydroxy-L-proline dehydratase
Gene namesi
Name:l3hypdh
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1000732. l3hypdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Trans-L-3-hydroxyproline dehydratasePRO_0000288952Add
BLAST

Proteomic databases

PaxDbiQ66II5.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037091.

Structurei

3D structure databases

ProteinModelPortaliQ66II5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 1032Substrate bindingBy similarity
Regioni268 – 2692Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the proline racemase family.Curated

Phylogenomic databases

eggNOGiENOG410IIC6. Eukaryota.
COG3938. LUCA.
HOGENOMiHOG000084336.
HOVERGENiHBG057443.
InParanoidiQ66II5.
KOiK18384.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66II5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRLPQLP PHDGPMLSVV DMHTGGEPLR IVLSGAPAPE GRTILEKRRW
60 70 80 90 100
VRENADWLRK VLMFEPRGHR DMYGALLVPG DEEEANIGVL FMHNEGYSTM
110 120 130 140 150
CGHAIVALGR FAVDYGLVNA AQGPETAVNI QCPCGLIRAY VSYTGGRSGS
160 170 180 190 200
VRFRSVPAFA FATDVTVDVP GYGKVVVDIA YGGAFYAFVS AETFGLDVCS
210 220 230 240 250
SRTRDLVDVS AAVTESVKAQ VKLNHPDSDD LAFLYGTILT DGKDSYSEEP
260 270 280 290 300
TANICIFAES QVDRSPTGSG VTARIALQYH KGLIQLEQIR TFKSGATGSL
310 320 330 340
FTGKAVKETL CGNFKAVVVE VSGQAYYTGA SSFVIENKDS LKDGFLLK
Length:348
Mass (Da):37,460
Last modified:October 11, 2004 - v1
Checksum:iD9D631AE9ECD639C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081335 mRNA. Translation: AAH81335.1.
RefSeqiNP_001008128.1. NM_001008127.1.
UniGeneiStr.26780.

Genome annotation databases

GeneIDi493490.
KEGGixtr:493490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081335 mRNA. Translation: AAH81335.1.
RefSeqiNP_001008128.1. NM_001008127.1.
UniGeneiStr.26780.

3D structure databases

ProteinModelPortaliQ66II5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037091.

Proteomic databases

PaxDbiQ66II5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493490.
KEGGixtr:493490.

Organism-specific databases

CTDi112849.
XenbaseiXB-GENE-1000732. l3hypdh.

Phylogenomic databases

eggNOGiENOG410IIC6. Eukaryota.
COG3938. LUCA.
HOGENOMiHOG000084336.
HOVERGENiHBG057443.
InParanoidiQ66II5.
KOiK18384.

Family and domain databases

InterProiIPR008794. Pro_racemase_fam.
[Graphical view]
PfamiPF05544. Pro_racemase. 1 hit.
[Graphical view]
PIRSFiPIRSF029792. Pro_racemase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT3HPD_XENTR
AccessioniPrimary (citable) accession number: Q66II5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 267 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.