Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q66I59

- ASPD_DANRE

UniProt

Q66I59 - ASPD_DANRE

Protein

Putative L-aspartate dehydrogenase

Gene

aspdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei126 – 1261NAD; via amide nitrogenBy similarity
    Binding sitei192 – 1921NADBy similarity

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative L-aspartate dehydrogenase (EC:1.4.1.21)
    Alternative name(s):
    Aspartate dehydrogenase domain-containing protein
    Gene namesi
    Name:aspdh
    ORF Names:zgc:103722
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040912-102. aspdh.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Putative L-aspartate dehydrogenasePRO_0000144903Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000055854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66I59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000007399.
    HOVERGENiHBG062283.
    InParanoidiQ66I59.
    PhylomeDBiQ66I59.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q66I59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL    50
    PKDLILHDLS DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL 100
    SDGQLEQDLR TAAKQQGKTL YVPSGALWGG QDIQKMNDSG TLRALSIRMS 150
    KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV AELCPLAPNN VNTMAAAAIA 200
    ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM RQNPAKLGAV 250
    TGKATYNSFW SSLLVCKGHG GRVYLC 276
    Length:276
    Mass (Da):29,753
    Last modified:October 11, 2004 - v1
    Checksum:i8DEC2D2AEB852CA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081519 mRNA. Translation: AAH81519.1.
    RefSeqiNP_001004657.1. NM_001004657.1.
    UniGeneiDr.87480.

    Genome annotation databases

    GeneIDi447919.
    KEGGidre:447919.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081519 mRNA. Translation: AAH81519.1 .
    RefSeqi NP_001004657.1. NM_001004657.1.
    UniGenei Dr.87480.

    3D structure databases

    ProteinModelPortali Q66I59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000055854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447919.
    KEGGi dre:447919.

    Organism-specific databases

    CTDi 554235.
    ZFINi ZDB-GENE-040912-102. aspdh.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000007399.
    HOVERGENi HBG062283.
    InParanoidi Q66I59.
    PhylomeDBi Q66I59.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .

    Miscellaneous databases

    NextBioi 20832438.
    PROi Q66I59.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiASPD_DANRE
    AccessioniPrimary (citable) accession number: Q66I59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3