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Protein

Putative L-aspartate dehydrogenase

Gene

aspdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261NAD; via amide nitrogenBy similarity
Binding sitei192 – 1921NADBy similarity

GO - Molecular functioni

  1. aspartate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:aspdh
ORF Names:zgc:103722
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040912-102. aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Putative L-aspartate dehydrogenasePRO_0000144903Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055854.

Structurei

3D structure databases

ProteinModelPortaliQ66I59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ66I59.
PhylomeDBiQ66I59.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66I59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL
60 70 80 90 100
PKDLILHDLS DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL
110 120 130 140 150
SDGQLEQDLR TAAKQQGKTL YVPSGALWGG QDIQKMNDSG TLRALSIRMS
160 170 180 190 200
KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV AELCPLAPNN VNTMAAAAIA
210 220 230 240 250
ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM RQNPAKLGAV
260 270
TGKATYNSFW SSLLVCKGHG GRVYLC
Length:276
Mass (Da):29,753
Last modified:October 11, 2004 - v1
Checksum:i8DEC2D2AEB852CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081519 mRNA. Translation: AAH81519.1.
RefSeqiNP_001004657.1. NM_001004657.1.
UniGeneiDr.87480.

Genome annotation databases

GeneIDi447919.
KEGGidre:447919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081519 mRNA. Translation: AAH81519.1.
RefSeqiNP_001004657.1. NM_001004657.1.
UniGeneiDr.87480.

3D structure databases

ProteinModelPortaliQ66I59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447919.
KEGGidre:447919.

Organism-specific databases

CTDi554235.
ZFINiZDB-GENE-040912-102. aspdh.

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ66I59.
PhylomeDBiQ66I59.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Miscellaneous databases

NextBioi20832438.
PROiQ66I59.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASPD_DANRE
AccessioniPrimary (citable) accession number: Q66I59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.