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Q66I59

- ASPD_DANRE

UniProt

Q66I59 - ASPD_DANRE

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Protein

Putative L-aspartate dehydrogenase

Gene

aspdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261NAD; via amide nitrogenBy similarity
Binding sitei192 – 1921NADBy similarity

GO - Molecular functioni

  1. aspartate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:aspdh
ORF Names:zgc:103722
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040912-102. aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Putative L-aspartate dehydrogenasePRO_0000144903Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055854.

Structurei

3D structure databases

ProteinModelPortaliQ66I59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ66I59.
PhylomeDBiQ66I59.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66I59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL
60 70 80 90 100
PKDLILHDLS DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL
110 120 130 140 150
SDGQLEQDLR TAAKQQGKTL YVPSGALWGG QDIQKMNDSG TLRALSIRMS
160 170 180 190 200
KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV AELCPLAPNN VNTMAAAAIA
210 220 230 240 250
ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM RQNPAKLGAV
260 270
TGKATYNSFW SSLLVCKGHG GRVYLC
Length:276
Mass (Da):29,753
Last modified:October 11, 2004 - v1
Checksum:i8DEC2D2AEB852CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081519 mRNA. Translation: AAH81519.1.
RefSeqiNP_001004657.1. NM_001004657.1.
UniGeneiDr.87480.

Genome annotation databases

GeneIDi447919.
KEGGidre:447919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081519 mRNA. Translation: AAH81519.1 .
RefSeqi NP_001004657.1. NM_001004657.1.
UniGenei Dr.87480.

3D structure databases

ProteinModelPortali Q66I59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000055854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447919.
KEGGi dre:447919.

Organism-specific databases

CTDi 554235.
ZFINi ZDB-GENE-040912-102. aspdh.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000007399.
HOVERGENi HBG062283.
InParanoidi Q66I59.
PhylomeDBi Q66I59.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .

Miscellaneous databases

NextBioi 20832438.
PROi Q66I59.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASPD_DANRE
AccessioniPrimary (citable) accession number: Q66I59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3