Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q66I59 (ASPD_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative L-aspartate dehydrogenase

EC=1.4.1.21
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene names
Name:aspdh
ORF Names:zgc:103722
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

NADP catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

aspartate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Putative L-aspartate dehydrogenase
PRO_0000144903

Sites

Binding site1261NAD; via amide nitrogen By similarity
Binding site1921NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66I59 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8DEC2D2AEB852CA9

FASTA27629,753
        10         20         30         40         50         60 
MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL PKDLILHDLS 

        70         80         90        100        110        120 
DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL SDGQLEQDLR TAAKQQGKTL 

       130        140        150        160        170        180 
YVPSGALWGG QDIQKMNDSG TLRALSIRMS KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV 

       190        200        210        220        230        240 
AELCPLAPNN VNTMAAAAIA ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM 

       250        260        270 
RQNPAKLGAV TGKATYNSFW SSLLVCKGHG GRVYLC 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081519 mRNA. Translation: AAH81519.1.
RefSeqNP_001004657.1. NM_001004657.1.
UniGeneDr.87480.

3D structure databases

ProteinModelPortalQ66I59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000055854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID447919.
KEGGdre:447919.

Organism-specific databases

CTD554235.
ZFINZDB-GENE-040912-102. aspdh.

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000007399.
HOVERGENHBG062283.
InParanoidQ66I59.
PhylomeDBQ66I59.

Enzyme and pathway databases

UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Other

NextBio20832438.
PROQ66I59.

Entry information

Entry nameASPD_DANRE
AccessionPrimary (citable) accession number: Q66I59
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways