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Protein

Putative L-aspartate dehydrogenase

Gene

aspdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative L-aspartate dehydrogenase (aspdh)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126NAD; via amide nitrogenBy similarity1
Binding sitei192NADBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:aspdh
ORF Names:zgc:103722
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040912-102. aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001449031 – 276Putative L-aspartate dehydrogenaseAdd BLAST276

Proteomic databases

PaxDbiQ66I59.

Structurei

3D structure databases

ProteinModelPortaliQ66I59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IKT3. Eukaryota.
ENOG410Y5EZ. LUCA.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ66I59.
PhylomeDBiQ66I59.

Family and domain databases

InterProiView protein in InterPro
IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66I59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL
60 70 80 90 100
PKDLILHDLS DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL
110 120 130 140 150
SDGQLEQDLR TAAKQQGKTL YVPSGALWGG QDIQKMNDSG TLRALSIRMS
160 170 180 190 200
KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV AELCPLAPNN VNTMAAAAIA
210 220 230 240 250
ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM RQNPAKLGAV
260 270
TGKATYNSFW SSLLVCKGHG GRVYLC
Length:276
Mass (Da):29,753
Last modified:October 11, 2004 - v1
Checksum:i8DEC2D2AEB852CA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081519 mRNA. Translation: AAH81519.1.
RefSeqiNP_001004657.1. NM_001004657.1.
UniGeneiDr.87480.

Genome annotation databases

GeneIDi447919.
KEGGidre:447919.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiASPD_DANRE
AccessioniPrimary (citable) accession number: Q66I59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 11, 2004
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families