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Protein

MAP kinase-interacting serine/threonine-protein kinase 2

Gene

mknk2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112ATPPROSITE-ProRule annotation1
Active sitei204Proton acceptorPROSITE-ProRule annotation1
Metal bindingi298ZincBy similarity1
Metal bindingi310ZincBy similarity1
Metal bindingi313ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 97ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase-interacting serine/threonine-protein kinase 2 (EC:2.7.11.1)
Alternative name(s):
MAP kinase signal-integrating kinase 2
Short name:
MAPK signal-integrating kinase 2
Short name:
Mnk2
Gene namesi
Name:mknk2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-491527. mknk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269671 – 466MAP kinase-interacting serine/threonine-protein kinase 2Add BLAST466

Proteomic databases

PaxDbiQ66I46.

Expressioni

Gene expression databases

BgeeiENSXETG00000013667.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000029916.

Structurei

3D structure databases

ProteinModelPortaliQ66I46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 367Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0607. Eukaryota.
ENOG410XQA9. LUCA.
HOGENOMiHOG000231140.
HOVERGENiHBG106949.
InParanoidiQ66I46.
KOiK04372.
OrthoDBiEOG091G0G1X.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66I46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKKTTEMK GFHRSFKGQN PFDAAYEMES RNMASVFNFD CPSRPDVPSS
60 70 80 90 100
APIDIPDAKK RTKKKKRCRA TDSFTGRFED MYQLQQEILG EGAYAKVQSC
110 120 130 140 150
INLITNKEYA VKIIEKRPGH SRSRVFREVE MLYQCQGHSN VLELIEFFEE
160 170 180 190 200
EDKFYLVFEK MCGGSILNHI HRRRHFNERE ASFVVRDIAE ALNYLHNKGI
210 220 230 240 250
AHRDLKPENI LCESPHQVSP VKICDFDLGS GIKLNSDCSP ISTPELLTPC
260 270 280 290 300
GSAEYMAPEV VEAFNEEASI YDKRCDLWSL GVILYIMLSG YPPFVGHCGS
310 320 330 340 350
DCGWDRGEAC PACQNMLFVS IQEGKYEFPE KDWAHISSGA KDLISKLLLR
360 370 380 390 400
DAKKRLSAAQ VLQHPWVQGN APDNTLPTPI ILQRNSSAKD LTSFAAEAIA
410 420 430 440 450
MNRQLMEREE EEEGTESSSS CPIVVKATSC SMQLSPPSES KLAKRRHGSK
460
GGISPPSLAP LLIVSD
Length:466
Mass (Da):52,313
Last modified:October 11, 2004 - v1
Checksum:i6E73EEED34AB04B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081543 mRNA. Translation: AAH81543.1.
RefSeqiNP_001072772.1. NM_001079304.1.
UniGeneiStr.15740.

Genome annotation databases

GeneIDi780232.
KEGGixtr:780232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081543 mRNA. Translation: AAH81543.1.
RefSeqiNP_001072772.1. NM_001079304.1.
UniGeneiStr.15740.

3D structure databases

ProteinModelPortaliQ66I46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000029916.

Proteomic databases

PaxDbiQ66I46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi780232.
KEGGixtr:780232.

Organism-specific databases

CTDi2872.
XenbaseiXB-GENE-491527. mknk2.

Phylogenomic databases

eggNOGiKOG0607. Eukaryota.
ENOG410XQA9. LUCA.
HOGENOMiHOG000231140.
HOVERGENiHBG106949.
InParanoidiQ66I46.
KOiK04372.
OrthoDBiEOG091G0G1X.

Gene expression databases

BgeeiENSXETG00000013667.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMKNK2_XENTR
AccessioniPrimary (citable) accession number: Q66I46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.