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Q66I24

- ASSY_DANRE

UniProt

Q66I24 - ASSY_DANRE

Protein

Argininosuccinate synthase

Gene

ass1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei86 – 861CitrullineBy similarity
    Binding sitei91 – 911CitrullineBy similarity
    Binding sitei118 – 1181AspartateBy similarity
    Binding sitei122 – 1221AspartateBy similarity
    Binding sitei122 – 1221CitrullineBy similarity
    Binding sitei123 – 1231AspartateBy similarity
    Binding sitei126 – 1261CitrullineBy similarity
    Binding sitei179 – 1791CitrullineBy similarity
    Binding sitei188 – 1881CitrullineBy similarity
    Binding sitei269 – 2691CitrullineBy similarity
    Binding sitei281 – 2811CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPBy similarity
    Nucleotide bindingi114 – 1229ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.
    UPA00158; UER00272.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:ass1
    Synonyms:ass
    ORF Names:zgc:92051
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040912-178. ass1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Argininosuccinate synthasePRO_0000321323Add
    BLAST

    Proteomic databases

    PRIDEiQ66I24.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000039902.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66I24.
    SMRiQ66I24. Positions 3-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    HOVERGENiHBG001717.
    InParanoidiQ66I24.
    KOiK01940.
    PhylomeDBiQ66I24.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66I24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKGLVVLAY SGGLDTSCIL VWLKEQGYDV IAYLANIGQD EDFDVARKKA    50
    EKLGAKKVFI EDLRSEFVQE FIWPALQANA LYEDRYLLGT SIARPCIARR 100
    QVQIAQREGA QYVSHGATGK GNDQVRFELT CYALYPQVQV IAPWRIPEFY 150
    NRFRGRKDLM EYAEKHNIPV PVTPKAPWSM DANLMHISYE SGILENPKNH 200
    APSDLYQMTK NPEHSPDQAD MLEIEFKKGV PVRVSHLKDG ISKETPLEIF 250
    CYLNEIGGKH GVGRIDIVEN RFIGMKSRGI YETPGGTVLL QAHLDIETFT 300
    MDREVRKIKQ SLGIKFSELI YNGFWFSPEC EFVRECVERS QKHVEGRVQL 350
    SVYKGQVYIL GRESPKSLYN EELVSMDVQG DYDPCDASGF IKINAVRLRE 400
    HNRLQGAALS KHNV 414
    Length:414
    Mass (Da):47,129
    Last modified:October 11, 2004 - v1
    Checksum:iA75FD4D9CD0611D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081578 mRNA. Translation: AAH81578.1.
    BC154282 mRNA. Translation: AAI54283.1.
    RefSeqiNP_001004603.1. NM_001004603.1.
    UniGeneiDr.4095.

    Genome annotation databases

    GeneIDi447864.
    KEGGidre:447864.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081578 mRNA. Translation: AAH81578.1 .
    BC154282 mRNA. Translation: AAI54283.1 .
    RefSeqi NP_001004603.1. NM_001004603.1.
    UniGenei Dr.4095.

    3D structure databases

    ProteinModelPortali Q66I24.
    SMRi Q66I24. Positions 3-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000039902.

    Proteomic databases

    PRIDEi Q66I24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447864.
    KEGGi dre:447864.

    Organism-specific databases

    CTDi 445.
    ZFINi ZDB-GENE-040912-178. ass1.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    HOVERGENi HBG001717.
    InParanoidi Q66I24.
    KOi K01940.
    PhylomeDBi Q66I24.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    UPA00158 ; UER00272 .

    Miscellaneous databases

    NextBioi 20832385.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiASSY_DANRE
    AccessioniPrimary (citable) accession number: Q66I24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3