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Q66I24 (ASSY_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:ass1
Synonyms:ass
ORF Names:zgc:92051
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
Urea cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000321323

Regions

Nucleotide binding9 – 179ATP By similarity
Nucleotide binding114 – 1229ATP By similarity

Sites

Binding site351ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site861Citrulline By similarity
Binding site911Citrulline By similarity
Binding site1181Aspartate By similarity
Binding site1221Aspartate By similarity
Binding site1221Citrulline By similarity
Binding site1231Aspartate By similarity
Binding site1261Citrulline By similarity
Binding site1791Citrulline By similarity
Binding site1881Citrulline By similarity
Binding site2691Citrulline By similarity
Binding site2811Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66I24 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A75FD4D9CD0611D3

FASTA41447,129
        10         20         30         40         50         60 
MSKGLVVLAY SGGLDTSCIL VWLKEQGYDV IAYLANIGQD EDFDVARKKA EKLGAKKVFI 

        70         80         90        100        110        120 
EDLRSEFVQE FIWPALQANA LYEDRYLLGT SIARPCIARR QVQIAQREGA QYVSHGATGK 

       130        140        150        160        170        180 
GNDQVRFELT CYALYPQVQV IAPWRIPEFY NRFRGRKDLM EYAEKHNIPV PVTPKAPWSM 

       190        200        210        220        230        240 
DANLMHISYE SGILENPKNH APSDLYQMTK NPEHSPDQAD MLEIEFKKGV PVRVSHLKDG 

       250        260        270        280        290        300 
ISKETPLEIF CYLNEIGGKH GVGRIDIVEN RFIGMKSRGI YETPGGTVLL QAHLDIETFT 

       310        320        330        340        350        360 
MDREVRKIKQ SLGIKFSELI YNGFWFSPEC EFVRECVERS QKHVEGRVQL SVYKGQVYIL 

       370        380        390        400        410 
GRESPKSLYN EELVSMDVQG DYDPCDASGF IKINAVRLRE HNRLQGAALS KHNV 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081578 mRNA. Translation: AAH81578.1.
BC154282 mRNA. Translation: AAI54283.1.
RefSeqNP_001004603.1. NM_001004603.1.
UniGeneDr.4095.

3D structure databases

ProteinModelPortalQ66I24.
SMRQ66I24. Positions 3-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000039902.

Proteomic databases

PRIDEQ66I24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID447864.
KEGGdre:447864.

Organism-specific databases

CTD445.
ZFINZDB-GENE-040912-178. ass1.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
HOVERGENHBG001717.
InParanoidQ66I24.
KOK01940.
PhylomeDBQ66I24.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.
UPA00158; UER00272.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832385.

Entry information

Entry nameASSY_DANRE
AccessionPrimary (citable) accession number: Q66I24
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways