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Q66I24

- ASSY_DANRE

UniProt

Q66I24 - ASSY_DANRE

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Protein

Argininosuccinate synthase

Gene
ass1, ass, zgc:92051
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei86 – 861Citrulline By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei179 – 1791Citrulline By similarity
Binding sitei188 – 1881Citrulline By similarity
Binding sitei269 – 2691Citrulline By similarity
Binding sitei281 – 2811Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity
Nucleotide bindingi114 – 1229ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
UPA00158; UER00272.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:ass1
Synonyms:ass
ORF Names:zgc:92051
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040912-178. ass1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Argininosuccinate synthaseUniRule annotationPRO_0000321323Add
BLAST

Proteomic databases

PRIDEiQ66I24.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000039902.

Structurei

3D structure databases

ProteinModelPortaliQ66I24.
SMRiQ66I24. Positions 3-405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
HOVERGENiHBG001717.
InParanoidiQ66I24.
KOiK01940.
PhylomeDBiQ66I24.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66I24-1 [UniParc]FASTAAdd to Basket

« Hide

MSKGLVVLAY SGGLDTSCIL VWLKEQGYDV IAYLANIGQD EDFDVARKKA    50
EKLGAKKVFI EDLRSEFVQE FIWPALQANA LYEDRYLLGT SIARPCIARR 100
QVQIAQREGA QYVSHGATGK GNDQVRFELT CYALYPQVQV IAPWRIPEFY 150
NRFRGRKDLM EYAEKHNIPV PVTPKAPWSM DANLMHISYE SGILENPKNH 200
APSDLYQMTK NPEHSPDQAD MLEIEFKKGV PVRVSHLKDG ISKETPLEIF 250
CYLNEIGGKH GVGRIDIVEN RFIGMKSRGI YETPGGTVLL QAHLDIETFT 300
MDREVRKIKQ SLGIKFSELI YNGFWFSPEC EFVRECVERS QKHVEGRVQL 350
SVYKGQVYIL GRESPKSLYN EELVSMDVQG DYDPCDASGF IKINAVRLRE 400
HNRLQGAALS KHNV 414
Length:414
Mass (Da):47,129
Last modified:October 11, 2004 - v1
Checksum:iA75FD4D9CD0611D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081578 mRNA. Translation: AAH81578.1.
BC154282 mRNA. Translation: AAI54283.1.
RefSeqiNP_001004603.1. NM_001004603.1.
UniGeneiDr.4095.

Genome annotation databases

GeneIDi447864.
KEGGidre:447864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081578 mRNA. Translation: AAH81578.1 .
BC154282 mRNA. Translation: AAI54283.1 .
RefSeqi NP_001004603.1. NM_001004603.1.
UniGenei Dr.4095.

3D structure databases

ProteinModelPortali Q66I24.
SMRi Q66I24. Positions 3-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000039902.

Proteomic databases

PRIDEi Q66I24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447864.
KEGGi dre:447864.

Organism-specific databases

CTDi 445.
ZFINi ZDB-GENE-040912-178. ass1.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
HOVERGENi HBG001717.
InParanoidi Q66I24.
KOi K01940.
PhylomeDBi Q66I24.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
UPA00158 ; UER00272 .

Miscellaneous databases

NextBioi 20832385.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiASSY_DANRE
AccessioniPrimary (citable) accession number: Q66I24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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