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Q66I24

- ASSY_DANRE

UniProt

Q66I24 - ASSY_DANRE

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Protein

Argininosuccinate synthase

Gene

ass1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351ATP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei86 – 861CitrullineBy similarity
Binding sitei91 – 911CitrullineBy similarity
Binding sitei118 – 1181AspartateBy similarity
Binding sitei122 – 1221AspartateBy similarity
Binding sitei122 – 1221CitrullineBy similarity
Binding sitei123 – 1231AspartateBy similarity
Binding sitei126 – 1261CitrullineBy similarity
Binding sitei179 – 1791CitrullineBy similarity
Binding sitei188 – 1881CitrullineBy similarity
Binding sitei269 – 2691CitrullineBy similarity
Binding sitei281 – 2811CitrullineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATPBy similarity
Nucleotide bindingi114 – 1229ATPBy similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
UPA00158; UER00272.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:ass1
Synonyms:ass
ORF Names:zgc:92051
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040912-178. ass1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Argininosuccinate synthasePRO_0000321323Add
BLAST

Proteomic databases

PRIDEiQ66I24.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000039902.

Structurei

3D structure databases

ProteinModelPortaliQ66I24.
SMRiQ66I24. Positions 3-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
HOVERGENiHBG001717.
InParanoidiQ66I24.
KOiK01940.
PhylomeDBiQ66I24.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66I24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKGLVVLAY SGGLDTSCIL VWLKEQGYDV IAYLANIGQD EDFDVARKKA
60 70 80 90 100
EKLGAKKVFI EDLRSEFVQE FIWPALQANA LYEDRYLLGT SIARPCIARR
110 120 130 140 150
QVQIAQREGA QYVSHGATGK GNDQVRFELT CYALYPQVQV IAPWRIPEFY
160 170 180 190 200
NRFRGRKDLM EYAEKHNIPV PVTPKAPWSM DANLMHISYE SGILENPKNH
210 220 230 240 250
APSDLYQMTK NPEHSPDQAD MLEIEFKKGV PVRVSHLKDG ISKETPLEIF
260 270 280 290 300
CYLNEIGGKH GVGRIDIVEN RFIGMKSRGI YETPGGTVLL QAHLDIETFT
310 320 330 340 350
MDREVRKIKQ SLGIKFSELI YNGFWFSPEC EFVRECVERS QKHVEGRVQL
360 370 380 390 400
SVYKGQVYIL GRESPKSLYN EELVSMDVQG DYDPCDASGF IKINAVRLRE
410
HNRLQGAALS KHNV
Length:414
Mass (Da):47,129
Last modified:October 11, 2004 - v1
Checksum:iA75FD4D9CD0611D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081578 mRNA. Translation: AAH81578.1.
BC154282 mRNA. Translation: AAI54283.1.
RefSeqiNP_001004603.1. NM_001004603.1.
UniGeneiDr.4095.

Genome annotation databases

GeneIDi447864.
KEGGidre:447864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081578 mRNA. Translation: AAH81578.1 .
BC154282 mRNA. Translation: AAI54283.1 .
RefSeqi NP_001004603.1. NM_001004603.1.
UniGenei Dr.4095.

3D structure databases

ProteinModelPortali Q66I24.
SMRi Q66I24. Positions 3-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000039902.

Proteomic databases

PRIDEi Q66I24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447864.
KEGGi dre:447864.

Organism-specific databases

CTDi 445.
ZFINi ZDB-GENE-040912-178. ass1.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
HOVERGENi HBG001717.
InParanoidi Q66I24.
KOi K01940.
PhylomeDBi Q66I24.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
UPA00158 ; UER00272 .

Miscellaneous databases

NextBioi 20832385.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiASSY_DANRE
AccessioniPrimary (citable) accession number: Q66I24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3