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Protein
Submitted name:

Transforming growth factor beta 3

Gene

tgfb3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell growth Source: InterPro
  • regulation of cartilage development Source: ZFIN
  • regulation of ossification Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Submitted name:
Transforming growth factor beta 3Imported
Submitted name:
Transforming growth factor, beta 3Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:tgfb3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-030723-4. tgfb3.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 410391Sequence analysisPRO_5007211316Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025519.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 410116TGF_BETA_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
KOiK13377.
OMAiPEPSVMT.
OrthoDBiEOG70GMFT.
TreeFamiTF351793.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR015618. TGFB3.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66I23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLGKGLLFV LLLNSVTMSL SLSTCTTVDI DNIKKKRVEA IRGQILSKLR
60 70 80 90 100
LTSPPQTLGP SQVPYQVLAL YNSTRDLLDG FGKDRHQSCG QDNTETEYYA
110 120 130 140 150
KEIHKFNMIQ GSPENNDLPY CPKGITSKVF RFDVSIMEKN ASNLFRAEFR
160 170 180 190 200
ALRMPNLSTS RTEQRIELYQ ILRPDEHIGK QRYIGRKNVM IGGTDEWVSF
210 220 230 240 250
DVTETVREWL TNRATNLGLE ISVHCPCHTF RPNGEIIENV NEALEVKFRG
260 270 280 290 300
MDVEDDGPIR SDMGRLKKPK EQNLPHLILM MLPPHRLDVL PTSRRRKRAL
310 320 330 340 350
DTKYCFSNYE ENCCVRKLYI DFRQDLGWRW IHEPKGYHAN FCSGPCPYLR
360 370 380 390 400
SADTTHSSLL SLYNTLNPEA SASPCCVPQD LEPLTILYYV GRTPKVEQLS
410
NMIVKSCKCS
Length:410
Mass (Da):46,983
Last modified:October 11, 2004 - v1
Checksum:iA0DDE6FFB1F02E31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP017289 Genomic DNA. No translation available.
FP325132 Genomic DNA. No translation available.
BC081579 mRNA. Translation: AAH81579.1.
AY614705 mRNA. Translation: AAU14139.1.
AY744929
, AY744923, AY744924, AY744925, AY744926, AY744927, AY744928 Genomic DNA. Translation: AAW66727.1.
RefSeqiNP_919367.2. NM_194386.2.
UniGeneiDr.116110.

Genome annotation databases

EnsembliENSDART00000019766; ENSDARP00000025519; ENSDARG00000019367.
GeneIDi369195.
KEGGidre:369195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP017289 Genomic DNA. No translation available.
FP325132 Genomic DNA. No translation available.
BC081579 mRNA. Translation: AAH81579.1.
AY614705 mRNA. Translation: AAU14139.1.
AY744929
, AY744923, AY744924, AY744925, AY744926, AY744927, AY744928 Genomic DNA. Translation: AAW66727.1.
RefSeqiNP_919367.2. NM_194386.2.
UniGeneiDr.116110.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000019766; ENSDARP00000025519; ENSDARG00000019367.
GeneIDi369195.
KEGGidre:369195.

Organism-specific databases

CTDi7043.
ZFINiZDB-GENE-030723-4. tgfb3.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000290198.
HOVERGENiHBG074115.
KOiK13377.
OMAiPEPSVMT.
OrthoDBiEOG70GMFT.
TreeFamiTF351793.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2129379. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi20813345.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR015618. TGFB3.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF001787. TGF-beta. 1 hit.
PRINTSiPR01423. TGFBETA.
PR01426. TGFBETA3.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cheah F.S.H., Jabs E.W., Chong S.S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. Cheah F.S.H., Jabs E.W., Chong S.S.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Genomic, cDNA, and embryonic expression analysis of zebrafish transforming growth factor beta 3 (tgfbeta3)."
    Cheah F.S., Jabs E.W., Chong S.S.
    Dev. Dyn. 232:1021-1030(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  6. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ66I23_DANRE
AccessioniPrimary (citable) accession number: Q66I23
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.