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Protein
Submitted name:

Transforming growth factor beta 3

Gene

tgfb3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Submitted name:
Transforming growth factor beta 3Imported
Submitted name:
Transforming growth factor, beta 3Imported
Gene namesi
Name:tgfb3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-030723-4 tgfb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501509811820 – 410Sequence analysisAdd BLAST391

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000019367

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025519

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 410TGF_BETA_2InterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000290198
HOVERGENiHBG074115
KOiK13377
OMAiPEPSVMT
OrthoDBiEOG091G0BMM
TreeFamiTF351793

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR015618 TGFB3
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF001787 TGF-beta, 1 hit
PRINTSiPR01423 TGFBETA
PR01426 TGFBETA3
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q66I23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLGKGLLFV LLLNSVTMSL SLSTCTTVDI DNIKKKRVEA IRGQILSKLR
60 70 80 90 100
LTSPPQTLGP SQVPYQVLAL YNSTRDLLDG FGKDRHQSCG QDNTETEYYA
110 120 130 140 150
KEIHKFNMIQ GSPENNDLPY CPKGITSKVF RFDVSIMEKN ASNLFRAEFR
160 170 180 190 200
ALRMPNLSTS RTEQRIELYQ ILRPDEHIGK QRYIGRKNVM IGGTDEWVSF
210 220 230 240 250
DVTETVREWL TNRATNLGLE ISVHCPCHTF RPNGEIIENV NEALEVKFRG
260 270 280 290 300
MDVEDDGPIR SDMGRLKKPK EQNLPHLILM MLPPHRLDVL PTSRRRKRAL
310 320 330 340 350
DTKYCFSNYE ENCCVRKLYI DFRQDLGWRW IHEPKGYHAN FCSGPCPYLR
360 370 380 390 400
SADTTHSSLL SLYNTLNPEA SASPCCVPQD LEPLTILYYV GRTPKVEQLS
410
NMIVKSCKCS
Length:410
Mass (Da):46,983
Last modified:October 11, 2004 - v1
Checksum:iA0DDE6FFB1F02E31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP017289 Genomic DNA No translation available.
FP325132 Genomic DNA No translation available.
BC081579 mRNA Translation: AAH81579.1
AY614705 mRNA Translation: AAU14139.1
AH014619
, AY744923, AY744924, AY744925, AY744926, AY744928 Genomic DNA Translation: AAW66727.1
RefSeqiNP_919367.2, NM_194386.2
UniGeneiDr.116110

Genome annotation databases

EnsembliENSDART00000019766; ENSDARP00000025519; ENSDARG00000019367
GeneIDi369195
KEGGidre:369195

Similar proteinsi

Entry informationi

Entry nameiQ66I23_DANRE
AccessioniPrimary (citable) accession number: Q66I23
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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