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Q66I21 (AL8A1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 8 member A1
EC=1.2.1.-
Gene names
Name:aldh8a1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Aldehyde dehydrogenase family 8 member A1
PRO_0000312956

Regions

Nucleotide binding231 – 2366NAD By similarity

Sites

Active site2531Proton acceptor By similarity
Active site2871Nucleophile By similarity
Site1551Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66I21 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4F13284B613DE146

FASTA48753,354
        10         20         30         40         50         60 
MSKDMKYLVL ENYIGGKFVP CSKLIDSFDP STGEVYCKVP DSGAEEVNAA VRAAKEAFPD 

        70         80         90        100        110        120 
WSAKSPADRS KVLNKLADLI EARLEEFVQA ESKDQGKTIT FARNVDIPRS AYNFRFFASS 

       130        140        150        160        170        180 
VLHHTNDCSQ MDHMGCLNYT IRCPVGVAGL ISPWNLPLYL LTWKIAPAVA TGNTVVAKPS 

       190        200        210        220        230        240 
EMTSVTAWMM CQLLEEAGFP PGVVNIVFGT GPRAGDALVS HPDVPLISFT GSTATARLIT 

       250        260        270        280        290        300 
ERSAPHCKKL SLELGGKNPA IIFADADMEQ CISTTVRSSF SNQGEICLCT SRIFVERSVY 

       310        320        330        340        350        360 
PEFLTRFVEA TRRWKTGVPS DPSNDNGALI SKEHLQKVKG YITLALAEGA QVHCGEGVDK 

       370        380        390        400        410        420 
LALPQQNIGG YFMLPTIISG VKDSSALMQE EIFGPVTCVT PFDEEEEVIS RANNVRYGLS 

       430        440        450        460        470        480 
ATVWSRDVGR VHRVARKLQA GLVWTNCWLV RDLNLPFGGM KHSGIGREGG KDSYHFFTEV 


KSVTVKH

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC081581 mRNA. Translation: AAH81581.1.
BC152164 mRNA. Translation: AAI52165.1.
IPIIPI00489851.
RefSeqNP_001004540.1. NM_001004540.1.
UniGeneDr.16380.

3D structure databases

HSSPHSSP built from PDB template 1ZUM based on UniProtKB P05091.
ProteinModelPortalQ66I21.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ66I21.

Proteomic databases

PRIDEQ66I21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000053399; ENSDARP00000053398; ENSDARG00000036776.
GeneID447801.
KEGGdre:447801.

Organism-specific databases

CTD64577.
ZFINZDB-GENE-040912-3. aldh8a1.

Phylogenomic databases

eggNOGfiNOG13497.
GeneTreeENSGT00560000077032.
HOGENOMHBG752218.
HOVERGENHBG000097.
InParanoidQ66I21.
OMALEECIPT.
OrthoDBEOG45HRX8.
PhylomeDBQ66I21.

Gene expression databases

ArrayExpressQ66I21.
BgeeQ66I21.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL8A1_DANRE
AccessionPrimary (citable) accession number: Q66I21
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: October 19, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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