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Protein

PDZ and LIM domain protein 3

Gene

Pdlim3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the organization of actin filament arrays within muscle cells.By similarity

GO - Molecular functioni

  • actinin binding Source: RGD
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 3
Alternative name(s):
Actinin-associated LIM protein
Alpha-actinin-2-associated LIM protein
SK-2
Gene namesi
Name:Pdlim3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620427. Pdlim3.

Subcellular locationi

GO - Cellular componenti

  • Z disc Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758701 – 362PDZ and LIM domain protein 3Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei92PhosphoserineBy similarity1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HS7.
PeptideAtlasiQ66HS7.
PRIDEiQ66HS7.

PTM databases

iPTMnetiQ66HS7.
PhosphoSitePlusiQ66HS7.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and at low levels in the heart.1 Publication

Developmental stagei

At E15 highly expressed in developing skeletal muscles, tongue, sternocephalic and tail. Weaker expression is seen in the heart atrium and ventricle. Expressed in a circular pattern in the intestine.

Gene expression databases

BgeeiENSRNOG00000012658.

Interactioni

Subunit structurei

Interacts with ACTN2.1 Publication

GO - Molecular functioni

  • actinin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017054.

Structurei

3D structure databases

ProteinModelPortaliQ66HS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZPROSITE-ProRule annotationAdd BLAST84
Domaini290 – 349LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiQ66HS7.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. Zasp-like_motif.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66HS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAEA ANLCPGDVIL
60 70 80 90 100
AIDGFGTESM THADAQDRIK AASYQLCLKI DRAETRLCPA VSEDGKAHPF
110 120 130 140 150
KINLEAEPQD VNYFEHKHNI RPKPFIIPGR TSGCSTPSGI DCGSGRSTPS
160 170 180 190 200
SVSTVSTICP GDLKVAAKMA PNIPLEMELP GVKIVHAQFN TPMQLYSDDN
210 220 230 240 250
IMETLQGQVS TALGETPSMS EPTASVPPQS DVYRMLHDNR DEPAAPRQSG
260 270 280 290 300
SFRVLQELVN DGSDDRPAGT RSVRPVTKVH GGAGGAQRMP LCDKCGSGIV
310 320 330 340 350
GAVVKARDKY RHPECFVCAD CNLNLKQKGY FFVEGELYCE MHARARTRPP
360
EGYDTVTLYP KA
Length:362
Mass (Da):39,106
Last modified:December 6, 2005 - v2
Checksum:i02D4174590F5DD78
GO
Isoform 2 (identifier: Q66HS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-173: DVNYFEHKHN...KVAAKMAPNI → EFKPIGTAHN...RGLIPSSPQN
     174-220: Missing.

Show »
Length:314
Mass (Da):34,120
Checksum:i12CA4E2EE60E7A21
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → S in AAC16671 (PubMed:9334352).Curated1
Sequence conflicti48V → M in AAC16671 (PubMed:9334352).Curated1
Sequence conflicti88 – 90CPA → WSPQ in AAH81703 (PubMed:15489334).Curated3
Sequence conflicti274R → RA in AAH81703 (PubMed:15489334).Curated1
Sequence conflicti347T → A in AAC16671 (PubMed:9334352).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016503110 – 173DVNYF…MAPNI → EFKPIGTAHNRRAQPFVAAA NIDDKRQVVSASYNSPIGLY STSNIRDALHGQLRGLIPSS PQN in isoform 2. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_016504174 – 220Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002281 mRNA. Translation: AAC16671.1.
BC081703 mRNA. Translation: AAH81703.1.
RefSeqiNP_446102.1. NM_053650.1.
XP_006253181.1. XM_006253119.3.
UniGeneiRn.13361.

Genome annotation databases

GeneIDi114108.
KEGGirno:114108.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002281 mRNA. Translation: AAC16671.1.
BC081703 mRNA. Translation: AAH81703.1.
RefSeqiNP_446102.1. NM_053650.1.
XP_006253181.1. XM_006253119.3.
UniGeneiRn.13361.

3D structure databases

ProteinModelPortaliQ66HS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017054.

PTM databases

iPTMnetiQ66HS7.
PhosphoSitePlusiQ66HS7.

Proteomic databases

PaxDbiQ66HS7.
PeptideAtlasiQ66HS7.
PRIDEiQ66HS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114108.
KEGGirno:114108.

Organism-specific databases

CTDi27295.
RGDi620427. Pdlim3.

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiQ66HS7.

Miscellaneous databases

PROiQ66HS7.

Gene expression databases

BgeeiENSRNOG00000012658.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. Zasp-like_motif.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI3_RAT
AccessioniPrimary (citable) accession number: Q66HS7
Secondary accession number(s): O70208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.