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Protein

Calcium-binding and coiled-coil domain-containing protein 1

Gene

Calcoco1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity).By similarity
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 1
Gene namesi
Name:Calcoco1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi619812. Calcoco1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between nucleus and cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Calcium-binding and coiled-coil domain-containing protein 1PRO_0000308902Add
BLAST

Proteomic databases

PaxDbiQ66HR5.
PRIDEiQ66HR5.

Expressioni

Gene expression databases

ExpressionAtlasiQ66HR5. baseline.
GenevisibleiQ66HR5. RN.

Interactioni

Subunit structurei

Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (By similarity). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064554.

Structurei

3D structure databases

ProteinModelPortaliQ66HR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 190190N-terminal AD (CTNNB1 binding site)By similarityAdd
BLAST
Regioni1 – 3030p300 KIX-bindingBy similarityAdd
BLAST
Regioni45 – 12581Interaction with GATA1By similarityAdd
BLAST
Regioni501 – 691191C-terminal AD (CTNNB1 binding site); interaction with CCAR1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 20561Sequence analysisAdd
BLAST
Coiled coili232 – 339108Sequence analysisAdd
BLAST
Coiled coili417 – 51498Sequence analysisAdd
BLAST

Domaini

The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).By similarity
The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).By similarity
Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.By similarity

Sequence similaritiesi

Belongs to the CALCOCO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHKH. Eukaryota.
ENOG410ZVZ6. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000111283.
HOVERGENiHBG107573.
InParanoidiQ66HR5.
OMAiYDMASGF.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ66HR5.
TreeFamiTF329501.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESSLSRAP SRGGVSFLNV ARTYVPNTKV ECHYTLPPGT TPSASDWIGI
60 70 80 90 100
FKVEAACVRD YHTFVWSSVP ETTTDGSPTH ASVQFQASYL PKPGAQLYQF
110 120 130 140 150
RYVNRQGRVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ
160 170 180 190 200
NQLDESQQER NDLMQLKLQL EDQVTELRSR VQELEAALAT ARQEHSELTE
210 220 230 240 250
QYKGLSRSHG ELSEERDILS QQQGEHVARI LELEDDIQTM SDKVLMKEVE
260 270 280 290 300
LDRVRDMVKA LTREQEKLLG QLKEFQADKE QSEAELQTVR EENCHLNTEL
310 320 330 340 350
QEAKGRQEEQ GAQVQRLKDK VAHMKDTLGQ TQQKVAELEP LKEQLRGVQE
360 370 380 390 400
LAASSQQKAA LLGEELASAA GARDRTIAEL HRSRLEVAEV NGRLAELSLH
410 420 430 440 450
MKEEKCQWSK ERTGLLQSME AEKDKILKLS AEILRLEKTV QEERSQSHMF
460 470 480 490 500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ TEKQELLEYM
510 520 530 540 550
RKLEARLEKV ADEKWNEDAA TEDEEATAGL SCPAALTDSE DESPEDMRLP
560 570 580 590 600
SYGLCERGNT SSSPPGPRES SSLVVINQPA PIAPQLSGPG EASSSDSEAE
610 620 630 640 650
DEKSVLMAAV QSGGEEANLL LPELGSTFYD VASGFAVSSL SEASTGVPAI
660 670 680 690
PAWKECPICK ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E
Length:691
Mass (Da):77,275
Last modified:October 11, 2004 - v1
Checksum:i5FC303C292883476
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041N → D in AAL85572 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078385 mRNA. Translation: AAL85572.1.
BC081722 mRNA. Translation: AAH81722.1.
RefSeqiNP_631929.1. NM_139190.1.
XP_003750466.1. XM_003750418.3.
UniGeneiRn.162973.

Genome annotation databases

EnsembliENSRNOT00000021523; ENSRNOP00000021522; ENSRNOG00000015447.
ENSRNOT00000070855; ENSRNOP00000064554; ENSRNOG00000048982.
GeneIDi100912282.
246047.
KEGGirno:100912282.
rno:246047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078385 mRNA. Translation: AAL85572.1.
BC081722 mRNA. Translation: AAH81722.1.
RefSeqiNP_631929.1. NM_139190.1.
XP_003750466.1. XM_003750418.3.
UniGeneiRn.162973.

3D structure databases

ProteinModelPortaliQ66HR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064554.

Proteomic databases

PaxDbiQ66HR5.
PRIDEiQ66HR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021523; ENSRNOP00000021522; ENSRNOG00000015447.
ENSRNOT00000070855; ENSRNOP00000064554; ENSRNOG00000048982.
GeneIDi100912282.
246047.
KEGGirno:100912282.
rno:246047.

Organism-specific databases

CTDi57658.
RGDi619812. Calcoco1.

Phylogenomic databases

eggNOGiENOG410IHKH. Eukaryota.
ENOG410ZVZ6. LUCA.
GeneTreeiENSGT00530000063216.
HOGENOMiHOG000111283.
HOVERGENiHBG107573.
InParanoidiQ66HR5.
OMAiYDMASGF.
OrthoDBiEOG7RRF8H.
PhylomeDBiQ66HR5.
TreeFamiTF329501.

Miscellaneous databases

NextBioi623311.
PROiQ66HR5.

Gene expression databases

ExpressionAtlasiQ66HR5. baseline.
GenevisibleiQ66HR5. RN.

Family and domain databases

InterProiIPR012852. CALCOCO1-like.
[Graphical view]
PfamiPF07888. CALCOCO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Vie-Luton M.-P., Francon J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: OFA-SD.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCACO1_RAT
AccessioniPrimary (citable) accession number: Q66HR5
Secondary accession number(s): Q8R443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: February 17, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.