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Q66HL5

- Q66HL5_RAT

UniProt

Q66HL5 - Q66HL5_RAT

Protein
Submitted name:

Serine (Or cysteine) peptidase inhibitor, clade A, member 5

Gene

Serpina5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatidylcholine binding Source: Ensembl
    2. retinoic acid binding Source: Ensembl
    3. serine-type endopeptidase inhibitor activity Source: RGD

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. negative regulation of proteolysis Source: RGD
    3. regulation of blood coagulation Source: RGD
    4. spermatogenesis Source: Ensembl

    Protein family/group databases

    MEROPSiI04.004.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine (Or cysteine) peptidase inhibitor, clade A, member 5Imported
    Submitted name:
    Serpina5 proteinImported
    Gene namesi
    Name:Serpina5Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi619817. Serpina5.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. extracellular region Source: RefGenome
    4. extracellular space Source: InterPro
    5. extracellular vesicular exosome Source: Ensembl
    6. platelet alpha granule Source: Ensembl
    7. platelet dense tubular network Source: Ensembl
    8. protein C inhibitor-coagulation factor V complex Source: Ensembl
    9. protein C inhibitor-coagulation factor Xa complex Source: Ensembl
    10. protein C inhibitor-coagulation factor XI complex Source: Ensembl
    11. protein C inhibitor-KLK3 complex Source: Ensembl
    12. protein C inhibitor-plasma kallikrein complex Source: Ensembl
    13. protein C inhibitor-PLAT complex Source: Ensembl
    14. protein C inhibitor-PLAU complex Source: Ensembl
    15. protein C inhibitor-thrombin complex Source: Ensembl
    16. protein C inhibitor-TMPRSS11E complex Source: Ensembl
    17. protein C inhibitor-TMPRSS7 complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ66HL5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG005957.
    InParanoidiQ66HL5.
    KOiK03913.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q66HL5-1 [UniParc]FASTAAdd to Basket

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    MRFFPILCLV LFFSHGVASR QRSHSKEKKK SKESSVGAVG TSRSRDFAFR    50
    LYRALASEAP GQNVFFSPMS VSMSLGMLSL GSGLKTKAQI LEGLGLSLQQ 100
    GQEDMLHKGF QQLLQQFSQP SDGLQLSLGS ALFTDPAVHI RDHFLSAMKT 150
    LYMSDMFSTN FGNPESAKKQ INDYVAKKTN GKIVDLIKDL DSTHVMVVVN 200
    YIFFKAKWQT AFSSTNTHKM DYHVTPKKTI QVPMMNREDI YSYILDQNIS 250
    CTVVGIPYQG NTFALFILPS EGKMKRVEDG LDERTLRNWL KMFTKRQLDL 300
    YLPKFSIEGT YKLEKILPKL GIQDIFTTHA DLSGLTDHTN IKLSEMVHKS 350
    MVEVDESGTT AAASTGILFT LRSARPSSLK VEFTRPFLVV IMDGTNLYFI 400
    GKVIQP 406
    Length:406
    Mass (Da):45,608
    Last modified:October 11, 2004 - v1
    Checksum:i224DC0E29EE5F68D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081797 mRNA. Translation: AAH81797.1.
    BC097315 mRNA. Translation: AAH97315.1.
    RefSeqiNP_001231668.1. NM_001244739.1.
    NP_075246.3. NM_022957.3.
    UniGeneiRn.30006.

    Genome annotation databases

    GeneIDi65051.
    KEGGirno:65051.
    UCSCiRGD:619817. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081797 mRNA. Translation: AAH81797.1 .
    BC097315 mRNA. Translation: AAH97315.1 .
    RefSeqi NP_001231668.1. NM_001244739.1.
    NP_075246.3. NM_022957.3.
    UniGenei Rn.30006.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65051.
    KEGGi rno:65051.
    UCSCi RGD:619817. rat.

    Organism-specific databases

    CTDi 5104.
    RGDi 619817. Serpina5.

    Phylogenomic databases

    HOVERGENi HBG005957.
    InParanoidi Q66HL5.
    KOi K03913.
    TreeFami TF343201.

    Miscellaneous databases

    NextBioi 613899.
    PROi Q66HL5.

    Gene expression databases

    Genevestigatori Q66HL5.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ66HL5_RAT
    AccessioniPrimary (citable) accession number: Q66HL5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)