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Protein
Submitted name:

Serine (Or cysteine) peptidase inhibitor, clade A, member 5

Gene

Serpina5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • negative regulation of proteolysis Source: RGD
  • regulation of blood coagulation Source: RGD
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_323052. Common Pathway of Fibrin Clot Formation.
REACT_343460. Intrinsic Pathway of Fibrin Clot Formation.

Protein family/group databases

MEROPSiI04.004.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade A, member 5Imported
Submitted name:
Serpina5 proteinImported
Gene namesi
Name:Serpina5Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619817. Serpina5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ66HL5. baseline.
GenevestigatoriQ66HL5.

Structurei

3D structure databases

ProteinModelPortaliQ66HL5.
SMRiQ66HL5. Positions 46-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005957.
KOiK03913.
PhylomeDBiQ66HL5.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66HL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFPILCLV LFFSHGVASR QRSHSKEKKK SKESSVGAVG TSRSRDFAFR
60 70 80 90 100
LYRALASEAP GQNVFFSPMS VSMSLGMLSL GSGLKTKAQI LEGLGLSLQQ
110 120 130 140 150
GQEDMLHKGF QQLLQQFSQP SDGLQLSLGS ALFTDPAVHI RDHFLSAMKT
160 170 180 190 200
LYMSDMFSTN FGNPESAKKQ INDYVAKKTN GKIVDLIKDL DSTHVMVVVN
210 220 230 240 250
YIFFKAKWQT AFSSTNTHKM DYHVTPKKTI QVPMMNREDI YSYILDQNIS
260 270 280 290 300
CTVVGIPYQG NTFALFILPS EGKMKRVEDG LDERTLRNWL KMFTKRQLDL
310 320 330 340 350
YLPKFSIEGT YKLEKILPKL GIQDIFTTHA DLSGLTDHTN IKLSEMVHKS
360 370 380 390 400
MVEVDESGTT AAASTGILFT LRSARPSSLK VEFTRPFLVV IMDGTNLYFI

GKVIQP
Length:406
Mass (Da):45,608
Last modified:October 11, 2004 - v1
Checksum:i224DC0E29EE5F68D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081797 mRNA. Translation: AAH81797.1.
BC097315 mRNA. Translation: AAH97315.1.
RefSeqiNP_001231668.1. NM_001244739.1.
NP_075246.3. NM_022957.3.
UniGeneiRn.30006.

Genome annotation databases

GeneIDi65051.
KEGGirno:65051.
UCSCiRGD:619817. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081797 mRNA. Translation: AAH81797.1.
BC097315 mRNA. Translation: AAH97315.1.
RefSeqiNP_001231668.1. NM_001244739.1.
NP_075246.3. NM_022957.3.
UniGeneiRn.30006.

3D structure databases

ProteinModelPortaliQ66HL5.
SMRiQ66HL5. Positions 46-406.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65051.
KEGGirno:65051.
UCSCiRGD:619817. rat.

Organism-specific databases

CTDi5104.
RGDi619817. Serpina5.

Phylogenomic databases

HOVERGENiHBG005957.
KOiK03913.
PhylomeDBiQ66HL5.
TreeFamiTF343201.

Enzyme and pathway databases

ReactomeiREACT_323052. Common Pathway of Fibrin Clot Formation.
REACT_343460. Intrinsic Pathway of Fibrin Clot Formation.

Miscellaneous databases

NextBioi613899.

Gene expression databases

ExpressionAtlasiQ66HL5. baseline.
GenevestigatoriQ66HL5.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiQ66HL5_RAT
AccessioniPrimary (citable) accession number: Q66HL5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 27, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.