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Q66HL5 (Q66HL5_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Serpina5 protein EMBL AAH81797.1
Gene names
Name:Serpina5 EMBL AAH81797.1 RGD 619817
OrganismRattus norvegicus (Rat) EMBL AAH81797.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Gene Ontology (GO)
   Biological_processnegative regulation of endopeptidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of proteolysis

Inferred from direct assay PubMed 16088033. Source: RGD

regulation of blood coagulation

Non-traceable author statement PubMed 9662429. Source: RGD

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentacrosomal membrane

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from Biological aspect of Ancestor. Source: RefGenome

extracellular space

Inferred from electronic annotation. Source: InterPro

extracellular vesicular exosome

Inferred from electronic annotation. Source: Ensembl

platelet alpha granule

Inferred from electronic annotation. Source: Ensembl

platelet dense tubular network

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-KLK3 complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-PLAT complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-PLAU complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-TMPRSS11E complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-TMPRSS7 complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-coagulation factor V complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-coagulation factor XI complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-coagulation factor Xa complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-plasma kallikrein complex

Inferred from electronic annotation. Source: Ensembl

protein C inhibitor-thrombin complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphosphatidylcholine binding

Inferred from electronic annotation. Source: Ensembl

retinoic acid binding

Inferred from electronic annotation. Source: Ensembl

serine-type endopeptidase inhibitor activity

Inferred from direct assay PubMed 16088033. Source: RGD

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q66HL5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 224DC0E29EE5F68D

FASTA40645,608
        10         20         30         40         50         60 
MRFFPILCLV LFFSHGVASR QRSHSKEKKK SKESSVGAVG TSRSRDFAFR LYRALASEAP 

        70         80         90        100        110        120 
GQNVFFSPMS VSMSLGMLSL GSGLKTKAQI LEGLGLSLQQ GQEDMLHKGF QQLLQQFSQP 

       130        140        150        160        170        180 
SDGLQLSLGS ALFTDPAVHI RDHFLSAMKT LYMSDMFSTN FGNPESAKKQ INDYVAKKTN 

       190        200        210        220        230        240 
GKIVDLIKDL DSTHVMVVVN YIFFKAKWQT AFSSTNTHKM DYHVTPKKTI QVPMMNREDI 

       250        260        270        280        290        300 
YSYILDQNIS CTVVGIPYQG NTFALFILPS EGKMKRVEDG LDERTLRNWL KMFTKRQLDL 

       310        320        330        340        350        360 
YLPKFSIEGT YKLEKILPKL GIQDIFTTHA DLSGLTDHTN IKLSEMVHKS MVEVDESGTT 

       370        380        390        400 
AAASTGILFT LRSARPSSLK VEFTRPFLVV IMDGTNLYFI GKVIQP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis EMBL AAH81797.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081797 mRNA. Translation: AAH81797.1.
BC097315 mRNA. Translation: AAH97315.1.
RefSeqNP_001231668.1. NM_001244739.1.
NP_075246.3. NM_022957.3.
UniGeneRn.30006.

3D structure databases

SMRQ66HL5. Positions 46-406.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65051.
KEGGrno:65051.
UCSCRGD:619817. rat.

Organism-specific databases

CTD5104.
RGD619817. Serpina5.

Phylogenomic databases

HOVERGENHBG005957.
InParanoidQ66HL5.
KOK03913.
PhylomeDBQ66HL5.
TreeFamTF343201.

Gene expression databases

GenevestigatorQ66HL5.

Family and domain databases

InterProIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

NextBio613899.
PROQ66HL5.

Entry information

Entry nameQ66HL5_RAT
AccessionPrimary (citable) accession number: Q66HL5
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)