Q66HL5 (Q66HL5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade A, member 5 EMBL AAH97315.1

Submitted name:
Serpina5 protein EMBL AAH81797.1

Gene names

Name:

Serpina5 RGD 619817

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Gene Ontology (GO)
Biological_process	negative regulation of proteolysis Inferred from direct assay PubMed 16088033. Source: RGD regulation of blood coagulation Non-traceable author statement PubMed 9662429. Source: RGD spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal membrane Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular region Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from electronic annotation. Source: Compara platelet alpha granule Inferred from electronic annotation. Source: Compara platelet dense tubular network Inferred from electronic annotation. Source: Compara protein C inhibitor-KLK3 complex Inferred from electronic annotation. Source: Compara protein C inhibitor-PLAT complex Inferred from electronic annotation. Source: Compara protein C inhibitor-PLAU complex Inferred from electronic annotation. Source: Compara protein C inhibitor-TMPRSS11E complex Inferred from electronic annotation. Source: Compara protein C inhibitor-TMPRSS7 complex Inferred from electronic annotation. Source: Compara protein C inhibitor-coagulation factor V complex Inferred from electronic annotation. Source: Compara protein C inhibitor-coagulation factor XI complex Inferred from electronic annotation. Source: Compara protein C inhibitor-coagulation factor Xa complex Inferred from electronic annotation. Source: Compara protein C inhibitor-plasma kallikrein complex Inferred from electronic annotation. Source: Compara protein C inhibitor-thrombin complex Inferred from electronic annotation. Source: Compara
Molecular_function	phosphatidylcholine binding Inferred from electronic annotation. Source: Compara retinoic acid binding Inferred from electronic annotation. Source: Compara serine-type endopeptidase inhibitor activity Inferred from direct assay PubMed 16088033. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q66HL5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 224DC0E29EE5F68D	FASTA	406	45,608
	10 20 30 40 50 60 MRFFPILCLV LFFSHGVASR QRSHSKEKKK SKESSVGAVG TSRSRDFAFR LYRALASEAP 70 80 90 100 110 120 GQNVFFSPMS VSMSLGMLSL GSGLKTKAQI LEGLGLSLQQ GQEDMLHKGF QQLLQQFSQP 130 140 150 160 170 180 SDGLQLSLGS ALFTDPAVHI RDHFLSAMKT LYMSDMFSTN FGNPESAKKQ INDYVAKKTN 190 200 210 220 230 240 GKIVDLIKDL DSTHVMVVVN YIFFKAKWQT AFSSTNTHKM DYHVTPKKTI QVPMMNREDI 250 260 270 280 290 300 YSYILDQNIS CTVVGIPYQG NTFALFILPS EGKMKRVEDG LDERTLRNWL KMFTKRQLDL 310 320 330 340 350 360 YLPKFSIEGT YKLEKILPKL GIQDIFTTHA DLSGLTDHTN IKLSEMVHKS MVEVDESGTT 370 380 390 400 AAASTGILFT LRSARPSSLK VEFTRPFLVV IMDGTNLYFI GKVIQP

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH81797.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081797 mRNA. Translation: AAH81797.1. BC097315 mRNA. Translation: AAH97315.1.
IPI	IPI00207600.
RefSeq	NP_001231668.1. NM_001244739.1. NP_075246.3. NM_022957.3.
UniGene	Rn.30006.
3D structure databases
SMR	Q66HL5. Positions 46-406.
ModBase	Search...
Protein family/group databases
MEROPS	I04.004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	65051.
KEGG	rno:65051.
UCSC	RGD:619817. rat.
Organism-specific databases
CTD	5104.
RGD	619817. Serpina5.
Phylogenomic databases
HOVERGEN	HBG005957.
InParanoid	Q66HL5.
KO	K03913.
OMA	QRIVFNR.
Gene expression databases
Genevestigator	Q66HL5.
Family and domain databases
InterPro	IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
ProtoNet	Search...
Other
NextBio	613899.

Entry information

Entry name

Q66HL5_RAT

Accession

Primary (citable) accession number: Q66HL5

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)