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Q66HL5

- Q66HL5_RAT

UniProt

Q66HL5 - Q66HL5_RAT

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Protein
Submitted name: Serine (Or cysteine) peptidase inhibitor, clade A, member 5
Gene
Serpina5
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phosphatidylcholine binding Source: Ensembl
  2. retinoic acid binding Source: Ensembl
  3. serine-type endopeptidase inhibitor activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. negative regulation of proteolysis Source: RGD
  3. regulation of blood coagulation Source: RGD
  4. spermatogenesis Source: Ensembl
Complete GO annotation...

Protein family/group databases

MEROPSiI04.004.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade A, member 5Imported
Submitted name:
Serpina5 proteinImported
Gene namesi
Name:Serpina5Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619817. Serpina5.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal membrane Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. extracellular region Source: RefGenome
  4. extracellular space Source: InterPro
  5. extracellular vesicular exosome Source: Ensembl
  6. platelet alpha granule Source: Ensembl
  7. platelet dense tubular network Source: Ensembl
  8. protein C inhibitor-KLK3 complex Source: Ensembl
  9. protein C inhibitor-PLAT complex Source: Ensembl
  10. protein C inhibitor-PLAU complex Source: Ensembl
  11. protein C inhibitor-TMPRSS11E complex Source: Ensembl
  12. protein C inhibitor-TMPRSS7 complex Source: Ensembl
  13. protein C inhibitor-coagulation factor V complex Source: Ensembl
  14. protein C inhibitor-coagulation factor XI complex Source: Ensembl
  15. protein C inhibitor-coagulation factor Xa complex Source: Ensembl
  16. protein C inhibitor-plasma kallikrein complex Source: Ensembl
  17. protein C inhibitor-thrombin complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ66HL5.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005957.
InParanoidiQ66HL5.
KOiK03913.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66HL5-1 [UniParc]FASTAAdd to Basket

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MRFFPILCLV LFFSHGVASR QRSHSKEKKK SKESSVGAVG TSRSRDFAFR    50
LYRALASEAP GQNVFFSPMS VSMSLGMLSL GSGLKTKAQI LEGLGLSLQQ 100
GQEDMLHKGF QQLLQQFSQP SDGLQLSLGS ALFTDPAVHI RDHFLSAMKT 150
LYMSDMFSTN FGNPESAKKQ INDYVAKKTN GKIVDLIKDL DSTHVMVVVN 200
YIFFKAKWQT AFSSTNTHKM DYHVTPKKTI QVPMMNREDI YSYILDQNIS 250
CTVVGIPYQG NTFALFILPS EGKMKRVEDG LDERTLRNWL KMFTKRQLDL 300
YLPKFSIEGT YKLEKILPKL GIQDIFTTHA DLSGLTDHTN IKLSEMVHKS 350
MVEVDESGTT AAASTGILFT LRSARPSSLK VEFTRPFLVV IMDGTNLYFI 400
GKVIQP 406
Length:406
Mass (Da):45,608
Last modified:October 11, 2004 - v1
Checksum:i224DC0E29EE5F68D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081797 mRNA. Translation: AAH81797.1.
BC097315 mRNA. Translation: AAH97315.1.
RefSeqiNP_001231668.1. NM_001244739.1.
NP_075246.3. NM_022957.3.
UniGeneiRn.30006.

Genome annotation databases

GeneIDi65051.
KEGGirno:65051.
UCSCiRGD:619817. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081797 mRNA. Translation: AAH81797.1 .
BC097315 mRNA. Translation: AAH97315.1 .
RefSeqi NP_001231668.1. NM_001244739.1.
NP_075246.3. NM_022957.3.
UniGenei Rn.30006.

3D structure databases

ModBasei Search...

Protein family/group databases

MEROPSi I04.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65051.
KEGGi rno:65051.
UCSCi RGD:619817. rat.

Organism-specific databases

CTDi 5104.
RGDi 619817. Serpina5.

Phylogenomic databases

HOVERGENi HBG005957.
InParanoidi Q66HL5.
KOi K03913.
TreeFami TF343201.

Miscellaneous databases

NextBioi 613899.
PROi Q66HL5.

Gene expression databases

Genevestigatori Q66HL5.

Family and domain databases

InterProi IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiQ66HL5_RAT
AccessioniPrimary (citable) accession number: Q66HL5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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