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Q66HL2

- Q66HL2_RAT

UniProt

Q66HL2 - Q66HL2_RAT

Protein
Submitted name:

Cortactin

Gene

Cttn

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. proline-rich region binding Source: RGD
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: RGD
    2. receptor-mediated endocytosis Source: RGD

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CortactinImported
    Submitted name:
    Cortactin, isoform CRA_eImported
    Submitted name:
    Protein CttnImported
    Gene namesi
    Name:CttnImported
    ORF Names:rCG_48092Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi619839. Cttn.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. lamellipodium Source: InterPro
    3. ruffle Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ66HL2.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062953.
    HOGENOMiHOG000006523.
    HOVERGENiHBG005994.
    KOiK06106.
    OMAiHESQQDY.
    OrthoDBiEOG7V49ZC.
    TreeFamiTF318935.

    Family and domain databases

    InterProiIPR015503. Cortactin.
    IPR003134. Hs1_Cortactin.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10829:SF15. PTHR10829:SF15. 1 hit.
    PfamiPF02218. HS1_rep. 6 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS51090. CORTACTIN. 6 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66HL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKASAGHAV SITQDDGGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ    50
    EHINIHKLRE NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV 100
    GHEYQSKLSK HCSQVDSVRG FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS 150
    QKDYSSGFGG KYGVQADRVD KSAVGFDYQG KTEKHESQKD YSKGFGGKYG 200
    IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT DRQDKCALGW 250
    DHQEKLQLHE SQKDYAKGFG GKYGVQKDRM DKNASTFEEV VQVPSAYQKT 300
    VPIEAVTSKT SNIRANFENL AKEREQEDRR KAEAERAQRM AQERQEQEEA 350
    RRKLEEQARA KKQTPPASPS PQPAEDRPPS SPIYEDAAPL KAEPSYGSSE 400
    PEPEYSTEAA GLPEASNQQG LAYTSEPVYE TTEVPGHYQA EDDTYDGYES 450
    DLGITAIALY DYQAAGDDEI SFDPDDVITN IEMIDDGWWR GVCKGRYGLF 500
    PANYVELRQ 509
    Length:509
    Mass (Da):56,942
    Last modified:October 11, 2004 - v1
    Checksum:i059CDB52681E2592
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009380 Genomic DNA. No translation available.
    AABR06009448 Genomic DNA. No translation available.
    BC081802 mRNA. Translation: AAH81802.1.
    CH473953 Genomic DNA. Translation: EDM12238.1.
    RefSeqiNP_068640.2. NM_021868.2.
    UniGeneiRn.107869.

    Genome annotation databases

    EnsembliENSRNOT00000028283; ENSRNOP00000028283; ENSRNOG00000050994.
    ENSRNOT00000054859; ENSRNOP00000051742; ENSRNOG00000047280.
    GeneIDi60465.
    KEGGirno:60465.
    UCSCiRGD:619839. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06009380 Genomic DNA. No translation available.
    AABR06009448 Genomic DNA. No translation available.
    BC081802 mRNA. Translation: AAH81802.1 .
    CH473953 Genomic DNA. Translation: EDM12238.1 .
    RefSeqi NP_068640.2. NM_021868.2.
    UniGenei Rn.107869.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028283 ; ENSRNOP00000028283 ; ENSRNOG00000050994 .
    ENSRNOT00000054859 ; ENSRNOP00000051742 ; ENSRNOG00000047280 .
    GeneIDi 60465.
    KEGGi rno:60465.
    UCSCi RGD:619839. rat.

    Organism-specific databases

    CTDi 2017.
    RGDi 619839. Cttn.

    Phylogenomic databases

    GeneTreei ENSGT00530000062953.
    HOGENOMi HOG000006523.
    HOVERGENi HBG005994.
    KOi K06106.
    OMAi HESQQDY.
    OrthoDBi EOG7V49ZC.
    TreeFami TF318935.

    Miscellaneous databases

    NextBioi 612230.
    PROi Q66HL2.

    Gene expression databases

    Genevestigatori Q66HL2.

    Family and domain databases

    InterProi IPR015503. Cortactin.
    IPR003134. Hs1_Cortactin.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10829:SF15. PTHR10829:SF15. 1 hit.
    Pfami PF02218. HS1_rep. 6 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS51090. CORTACTIN. 6 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ66HL2_RAT
    AccessioniPrimary (citable) accession number: Q66HL2
    Secondary accession number(s): D3ZRB0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3