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Protein
Submitted name:

Prostaglandin G/H synthase 1

Gene

Ptgs1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-140180 COX reactions
R-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 1Imported
Submitted name:
Ptgs1 proteinImported
Submitted name:
RCG45926, isoform CRA_aImported
Gene namesi
Name:Ptgs1Imported
ORF Names:rCG_45926Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3439 Ptgs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501431026527 – 602Sequence analysisAdd BLAST576

Expressioni

Gene expression databases

BgeeiENSRNOG00000007415

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 72EGF-likeInterPro annotationAdd BLAST39

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
HOVERGENiHBG000366
KOiK00509
OMAiFKTSGKM
OrthoDBiEOG091G03CD
TreeFamiTF329675

Family and domain databases

Gene3Di1.10.640.101 hit
InterProiView protein in InterPro
IPR029580 COX-1
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF6 PTHR11903:SF6, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q66HK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRSLSLQF PLLLLLLLLP PPPVLLTDAG VPSPVNPCCY YPCQNQGVCV
60 70 80 90 100
RFGLDHYQCD CTRTGYSGPN CTIPEIWTWL RSSLRPSPSF THFLLTHGYW
110 120 130 140 150
IWEFVNATFI REVLMRLVLT VRSNLIPSPP TYNTAHDYIS WESFSNVSYY
160 170 180 190 200
TRILPSVPKD CPTPMGTKGK KQLPDIHLLA QRLLLRREFI PAPQGTNVLF
210 220 230 240 250
AFFAQHFTHQ FFKTSGKMGP GFTKALGHGV DLGHIYGDSL ERQYHLRLFK
260 270 280 290 300
DGKLKYQVLD GEVYPPSVEQ ASVLMRYPPG VPPEKQMAVG QEVFGLLPGL
310 320 330 340 350
MLFSTIWLRE HNRVCDLLKE EHPTWDDEQL FQTTRLILIG ETIKIIIEEY
360 370 380 390 400
VQHLSGYFLQ LKFDPELLFR AQFQYRNRIA LEFNHLYHWH PLMPDSFQVG
410 420 430 440 450
SQEYSYEQFL FNTSMLVDYG VEALVDAFSR QRAGRIGGGR NFDYHVLHVA
460 470 480 490 500
EDVIKESREM RLQSFNEYRK RFGLKPYTSF QEFTGEKEMA AELEELYGDI
510 520 530 540 550
DALEFYPGLM LEKCQPNSLF GESMIEMGAP FSLKGLLGNP ICSPEYWKPS
560 570 580 590 600
TFGGDVGFNI VNTASLKKLV CLNTKTCPYV SFRVPDYPGD DGSVFVRPST

EL
Length:602
Mass (Da):69,046
Last modified:October 11, 2004 - v1
Checksum:iFB9DEFE11DC12B2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106602 Genomic DNA No translation available.
BC081816 mRNA Translation: AAH81816.1
CH474001 Genomic DNA Translation: EDL93122.1
RefSeqiNP_058739.4, NM_017043.4
UniGeneiRn.44404

Genome annotation databases

EnsembliENSRNOT00000010218; ENSRNOP00000010218; ENSRNOG00000007415
GeneIDi24693
KEGGirno:24693

Similar proteinsi

Entry informationi

Entry nameiQ66HK3_RAT
AccessioniPrimary (citable) accession number: Q66HK3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported