Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein lyl-1

Gene

Lyl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1359244. Lyl1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Protein lyl-1PRO_0000369264Add
BLAST

Proteomic databases

PaxDbiQ66HH3.

Expressioni

Gene expression databases

GenevisibleiQ66HH3. RN.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003980.

Structurei

3D structure databases

ProteinModelPortaliQ66HH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 20153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
InParanoidiQ66HH3.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ66HH3.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPPQAQAEV GSAMTEKTEM VCTSSPAPAP PSKPASPGPL PAEEVDHRNT
60 70 80 90 100
CNPWLPPGVP VINLGHTRPT GAAMPTTELS AFRPSLLQLA ALGTAPPTLA
110 120 130 140 150
LHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHGELDLV DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQAA VLASGPSAPG SRKPPAHRGV EGNARCGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKMEQ TALSPEVR
Length:278
Mass (Da):29,957
Last modified:October 11, 2004 - v1
Checksum:i8B2873F2BA288839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081864 mRNA. Translation: AAH81864.1.
RefSeqiNP_001007678.1. NM_001007677.1.
UniGeneiRn.17352.

Genome annotation databases

EnsembliENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950.
GeneIDi304663.
KEGGirno:304663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081864 mRNA. Translation: AAH81864.1.
RefSeqiNP_001007678.1. NM_001007677.1.
UniGeneiRn.17352.

3D structure databases

ProteinModelPortaliQ66HH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003980.

Proteomic databases

PaxDbiQ66HH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950.
GeneIDi304663.
KEGGirno:304663.

Organism-specific databases

CTDi4066.
RGDi1359244. Lyl1.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
InParanoidiQ66HH3.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ66HH3.
TreeFamiTF315153.

Miscellaneous databases

NextBioi653440.
PROiQ66HH3.

Gene expression databases

GenevisibleiQ66HH3. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiLYL1_RAT
AccessioniPrimary (citable) accession number: Q66HH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.