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Protein

Protein Red

Gene

Ik

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May bind to chromatin.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Red
Alternative name(s):
Cytokine IK
IK factor
Gene namesi
Name:Ik
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359352. Ik.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Protein RedPRO_0000288497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-acetyllysineBy similarity
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei460 – 4601PhosphoserineBy similarity
Modified residuei485 – 4851PhosphothreonineBy similarity
Cross-linki544 – 544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ66HG8.
PRIDEiQ66HG8.

PTM databases

iPTMnetiQ66HG8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012906.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati342 – 34321
Repeati344 – 34522
Repeati346 – 34723
Repeati348 – 34924
Repeati350 – 35125
Repeati352 – 35326
Repeati354 – 35527
Repeati356 – 35728
Repeati358 – 35929
Repeati360 – 361210
Repeati362 – 363211
Repeati364 – 365212
Repeati366 – 367213
Repeati368 – 369214
Repeati370 – 371215
Repeati372 – 373216
Repeati374 – 375217

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 3753417 X 2 AA tandem repeats of R-[ED]Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi182 – 1876Poly-Glu

Sequence similaritiesi

Belongs to the RED family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2498. Eukaryota.
ENOG410YR3Z. LUCA.
HOGENOMiHOG000007717.
HOVERGENiHBG017223.
InParanoidiQ66HG8.
KOiK13109.

Family and domain databases

InterProiIPR012492. RED_C.
IPR012916. RED_N.
[Graphical view]
PfamiPF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
[Graphical view]
ProDomiPD311621. RED_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q66HG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA
60 70 80 90 100
PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR
110 120 130 140 150
DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES
160 170 180 190 200
KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE
210 220 230 240 250
DPENKIEFKT RLGRNVYRML FKSKSYERNE LFLPGRMAYV VDLDDEYADT
260 270 280 290 300
DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK
310 320 330 340 350
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER
360 370 380 390 400
DRDRERDRER DRERERERDR EREREEEKKR HSYFEKPKVD DEPMDVDKGP
410 420 430 440 450
GSAKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP
460 470 480 490 500
ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP
510 520 530 540 550
KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV

EVKRPKY
Length:557
Mass (Da):65,588
Last modified:October 11, 2004 - v1
Checksum:i15FD9334FC887113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081870 mRNA. Translation: AAH81870.1.
RefSeqiNP_001005537.1. NM_001005537.1.
UniGeneiRn.19642.

Genome annotation databases

GeneIDi291659.
KEGGirno:291659.
UCSCiRGD:1359352. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081870 mRNA. Translation: AAH81870.1.
RefSeqiNP_001005537.1. NM_001005537.1.
UniGeneiRn.19642.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012906.

PTM databases

iPTMnetiQ66HG8.

Proteomic databases

PaxDbiQ66HG8.
PRIDEiQ66HG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi291659.
KEGGirno:291659.
UCSCiRGD:1359352. rat.

Organism-specific databases

CTDi3550.
RGDi1359352. Ik.

Phylogenomic databases

eggNOGiKOG2498. Eukaryota.
ENOG410YR3Z. LUCA.
HOGENOMiHOG000007717.
HOVERGENiHBG017223.
InParanoidiQ66HG8.
KOiK13109.

Miscellaneous databases

PROiQ66HG8.

Family and domain databases

InterProiIPR012492. RED_C.
IPR012916. RED_N.
[Graphical view]
PfamiPF07807. RED_C. 1 hit.
PF07808. RED_N. 1 hit.
[Graphical view]
ProDomiPD311621. RED_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Diao W., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 108-127; 165-173; 229-236; 282-290; 310-331 AND 535-541, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiRED_RAT
AccessioniPrimary (citable) accession number: Q66HG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.