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Protein

Carbonic anhydrase 5B, mitochondrial

Gene

Ca5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi132Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi155Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5B, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VB
Carbonic anhydrase VB
Short name:
CA-VB
Gene namesi
Name:Ca5b
Synonyms:Car5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1549783. Ca5b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
ChainiPRO_000004194434 – 317Carbonic anhydrase 5B, mitochondrialAdd BLAST284

Proteomic databases

PaxDbiQ66HG6.
PRIDEiQ66HG6.

PTM databases

iPTMnetiQ66HG6.
PhosphoSitePlusiQ66HG6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029330.
GenevisibleiQ66HG6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043235.

Structurei

3D structure databases

ProteinModelPortaliQ66HG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 296Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 236Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiQ66HG6.
KOiK01672.
OMAiPDYWTYA.
OrthoDBiEOG091G0XFM.
PhylomeDBiQ66HG6.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018437. CA-VB_mt.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF25. PTHR18952:SF25. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVMSHLRVS LQVSSCTLLW RRFRVPRLVP LRSCSLYTCT YRTRNRALPP
60 70 80 90 100
LWENLDLVPA GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHIWNNGY
110 120 130 140 150
SFLVEFEDTT DKSVIEGGPL EHNYRLKQFH FHWGAIDAWG SEHTVDSKCY
160 170 180 190 200
PAELHLVHWN AVKFESFEDA ALEENGLAVI GVFLKLGKHH KELQKLVDTL
210 220 230 240 250
PSIKHKDTLV KFGSFDPSCL MPTCPDYWTY SGSLTTPPLS ESVTWIIKKQ
260 270 280 290 300
PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY
310
VLNIQVKPEP TASEVSP
Length:317
Mass (Da):36,598
Last modified:October 11, 2004 - v1
Checksum:iE8DF65463368618B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081872 mRNA. Translation: AAH81872.1.
RefSeqiNP_001005551.1. NM_001005551.2.
XP_006256921.1. XM_006256859.3.
UniGeneiRn.22441.

Genome annotation databases

EnsembliENSRNOT00000047354; ENSRNOP00000043235; ENSRNOG00000029330.
GeneIDi302669.
KEGGirno:302669.
UCSCiRGD:1549783. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081872 mRNA. Translation: AAH81872.1.
RefSeqiNP_001005551.1. NM_001005551.2.
XP_006256921.1. XM_006256859.3.
UniGeneiRn.22441.

3D structure databases

ProteinModelPortaliQ66HG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043235.

PTM databases

iPTMnetiQ66HG6.
PhosphoSitePlusiQ66HG6.

Proteomic databases

PaxDbiQ66HG6.
PRIDEiQ66HG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047354; ENSRNOP00000043235; ENSRNOG00000029330.
GeneIDi302669.
KEGGirno:302669.
UCSCiRGD:1549783. rat.

Organism-specific databases

CTDi11238.
RGDi1549783. Ca5b.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiQ66HG6.
KOiK01672.
OMAiPDYWTYA.
OrthoDBiEOG091G0XFM.
PhylomeDBiQ66HG6.
TreeFamiTF316425.

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

PROiQ66HG6.

Gene expression databases

BgeeiENSRNOG00000029330.
GenevisibleiQ66HG6. RN.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018437. CA-VB_mt.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF25. PTHR18952:SF25. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH5B_RAT
AccessioniPrimary (citable) accession number: Q66HG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.