Q66HG6 (CAH5B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 5B, mitochondrial
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase VB
Carbonic anhydrase VB
Short name=CA-VB

Gene names

Name:	Ca5b
Synonyms:	Car5b

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 33	33	Mitochondrion By similarity
	Chain	34 – 317	284	Carbonic anhydrase 5B, mitochondrial		PRO_0000041944
Regions
	Region	235 – 236	2	Substrate binding By similarity
Sites
	Metal binding	130	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity
	Metal binding	155	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66HG6 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E8DF65463368618B	FASTA	317	36,598
	10 20 30 40 50 60 MTVMSHLRVS LQVSSCTLLW RRFRVPRLVP LRSCSLYTCT YRTRNRALPP LWENLDLVPA 70 80 90 100 110 120 GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHIWNNGY SFLVEFEDTT DKSVIEGGPL 130 140 150 160 170 180 EHNYRLKQFH FHWGAIDAWG SEHTVDSKCY PAELHLVHWN AVKFESFEDA ALEENGLAVI 190 200 210 220 230 240 GVFLKLGKHH KELQKLVDTL PSIKHKDTLV KFGSFDPSCL MPTCPDYWTY SGSLTTPPLS 250 260 270 280 290 300 ESVTWIIKKQ PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY 310 VLNIQVKPEP TASEVSP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081872 mRNA. Translation: AAH81872.1.
IPI	IPI00358499.
RefSeq	NP_001005551.1. NM_001005551.1.
UniGene	Rn.22441.
3D structure databases
ProteinModelPortal	Q66HG6.
SMR	Q66HG6. Positions 61-297.
ModBase	Search...
Proteomic databases
PRIDE	Q66HG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000047354; ENSRNOP00000043235; ENSRNOG00000029330.
GeneID	302669.
KEGG	rno:302669.
UCSC	NM_001005551. rat.
Organism-specific databases
CTD	56078.
RGD	1549783. Ca5b.
Phylogenomic databases
eggNOG	roNOG11543.
GeneTree	ENSGT00560000076828.
HOVERGEN	HBG002837.
InParanoid	Q66HG6.
OMA	PAIKHKD.
OrthoDB	EOG4FR0RX.
PhylomeDB	Q66HG6.
Gene expression databases
ArrayExpress	Q66HG6.
Genevestigator	Q66HG6.
GermOnline	ENSRNOG00000029330. Rattus norvegicus.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018437. Carbonic_anhydrase_CA5_mt. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KO	K01672.
PANTHER	PTHR18952:SF25. Carbonic_anhydrase_CA5_mt. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	649971.

Entry information

Entry name

CAH5B_RAT

Accession

Primary (citable) accession number: Q66HG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program