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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Gene namesi
Name:Tm9sf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359230 Tm9sf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 300LumenalSequence analysisAdd BLAST272
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398LumenalSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 466LumenalSequence analysis8
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 554LumenalSequence analysisAdd BLAST11
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 591CytoplasmicSequence analysisAdd BLAST16
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 631LumenalSequence analysisAdd BLAST19
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436829 – 663Transmembrane 9 superfamily member 2Add BLAST635

Proteomic databases

PaxDbiQ66HG5
PRIDEiQ66HG5

PTM databases

SwissPalmiQ66HG5

Expressioni

Gene expression databases

BgeeiENSRNOG00000012751
GenevisibleiQ66HG5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017211

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216679
HOVERGENiHBG054197
InParanoidiQ66HG5
KOiK17086
OMAiWDKYLHV
OrthoDBiEOG091G03BD

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPPASLP ARGPRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCTEE
60 70 80 90 100
KKSNECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKEETC KLVCTKTYHT EKAEDKQKLD FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYEVEDN QKFCNPGFPI GCYITDKGHA KDACVISSEF
210 220 230 240 250
HERDTFYIFN HVDIKIQYHV VETGSMGARL VAAKLEPKSF RHTHIDKPDC
260 270 280 290 300
SGPAMDISNK ASGEIKIAYT YSISFEEEKN IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLVYAIHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,586
Last modified:October 11, 2004 - v1
Checksum:iD10FD1885D85AFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA Translation: AAH81873.1
RefSeqiNP_001005554.1, NM_001005554.1
UniGeneiRn.11839

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751
GeneIDi306197
KEGGirno:306197

Similar proteinsi

Entry informationi

Entry nameiTM9S2_RAT
AccessioniPrimary (citable) accession number: Q66HG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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