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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Gene namesi
Name:Tm9sf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359230. Tm9sf2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 300272LumenalSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Topological domaini322 – 37453CytoplasmicSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Topological domaini396 – 3983LumenalSequence analysis
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Topological domaini420 – 43718CytoplasmicSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 4668LumenalSequence analysis
Transmembranei467 – 48721HelicalSequence analysisAdd
BLAST
Topological domaini488 – 52235CytoplasmicSequence analysisAdd
BLAST
Transmembranei523 – 54321HelicalSequence analysisAdd
BLAST
Topological domaini544 – 55411LumenalSequence analysisAdd
BLAST
Transmembranei555 – 57521HelicalSequence analysisAdd
BLAST
Topological domaini576 – 59116CytoplasmicSequence analysisAdd
BLAST
Transmembranei592 – 61221HelicalSequence analysisAdd
BLAST
Topological domaini613 – 63119LumenalSequence analysisAdd
BLAST
Transmembranei632 – 65221HelicalSequence analysisAdd
BLAST
Topological domaini653 – 66311CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 663635Transmembrane 9 superfamily member 2PRO_0000034368Add
BLAST

Proteomic databases

PaxDbiQ66HG5.
PRIDEiQ66HG5.

PTM databases

SwissPalmiQ66HG5.

Expressioni

Gene expression databases

GenevisibleiQ66HG5. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4655750.
STRINGi10116.ENSRNOP00000017211.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ66HG5.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG757CWP.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPPASLP ARGPRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCTEE
60 70 80 90 100
KKSNECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKEETC KLVCTKTYHT EKAEDKQKLD FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYEVEDN QKFCNPGFPI GCYITDKGHA KDACVISSEF
210 220 230 240 250
HERDTFYIFN HVDIKIQYHV VETGSMGARL VAAKLEPKSF RHTHIDKPDC
260 270 280 290 300
SGPAMDISNK ASGEIKIAYT YSISFEEEKN IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLVYAIHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,586
Last modified:October 11, 2004 - v1
Checksum:iD10FD1885D85AFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA. Translation: AAH81873.1.
RefSeqiNP_001005554.1. NM_001005554.1.
UniGeneiRn.11839.

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751.
GeneIDi306197.
KEGGirno:306197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA. Translation: AAH81873.1.
RefSeqiNP_001005554.1. NM_001005554.1.
UniGeneiRn.11839.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4655750.
STRINGi10116.ENSRNOP00000017211.

PTM databases

SwissPalmiQ66HG5.

Proteomic databases

PaxDbiQ66HG5.
PRIDEiQ66HG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751.
GeneIDi306197.
KEGGirno:306197.

Organism-specific databases

CTDi9375.
RGDi1359230. Tm9sf2.

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ66HG5.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG757CWP.

Miscellaneous databases

NextBioi655612.
PROiQ66HG5.

Gene expression databases

GenevisibleiQ66HG5. RN.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiTM9S2_RAT
AccessioniPrimary (citable) accession number: Q66HG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: February 17, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.