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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Gene namesi
Name:Tm9sf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359230. Tm9sf2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 300LumenalSequence analysisAdd BLAST272
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398LumenalSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 466LumenalSequence analysis8
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 554LumenalSequence analysisAdd BLAST11
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 591CytoplasmicSequence analysisAdd BLAST16
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 631LumenalSequence analysisAdd BLAST19
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436829 – 663Transmembrane 9 superfamily member 2Add BLAST635

Proteomic databases

PaxDbiQ66HG5.
PRIDEiQ66HG5.

PTM databases

SwissPalmiQ66HG5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012751.
GenevisibleiQ66HG5. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4655750.
STRINGi10116.ENSRNOP00000017211.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ66HG5.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG091G03BD.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPPASLP ARGPRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCTEE
60 70 80 90 100
KKSNECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKEETC KLVCTKTYHT EKAEDKQKLD FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYEVEDN QKFCNPGFPI GCYITDKGHA KDACVISSEF
210 220 230 240 250
HERDTFYIFN HVDIKIQYHV VETGSMGARL VAAKLEPKSF RHTHIDKPDC
260 270 280 290 300
SGPAMDISNK ASGEIKIAYT YSISFEEEKN IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLVYAIHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,586
Last modified:October 11, 2004 - v1
Checksum:iD10FD1885D85AFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA. Translation: AAH81873.1.
RefSeqiNP_001005554.1. NM_001005554.1.
UniGeneiRn.11839.

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751.
GeneIDi306197.
KEGGirno:306197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA. Translation: AAH81873.1.
RefSeqiNP_001005554.1. NM_001005554.1.
UniGeneiRn.11839.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4655750.
STRINGi10116.ENSRNOP00000017211.

PTM databases

SwissPalmiQ66HG5.

Proteomic databases

PaxDbiQ66HG5.
PRIDEiQ66HG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751.
GeneIDi306197.
KEGGirno:306197.

Organism-specific databases

CTDi9375.
RGDi1359230. Tm9sf2.

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ66HG5.
KOiK17086.
OMAiNFCEEGK.
OrthoDBiEOG091G03BD.

Miscellaneous databases

PROiQ66HG5.

Gene expression databases

BgeeiENSRNOG00000012751.
GenevisibleiQ66HG5. RN.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S2_RAT
AccessioniPrimary (citable) accession number: Q66HG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.