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Protein

Aldose 1-epimerase

Gene

Galm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).By similarity

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton donorPROSITE-ProRule annotation1
Binding sitei243SubstrateBy similarity1
Active sitei307Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:Galm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359459. Galm.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974371 – 342Aldose 1-epimeraseAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HG4.
PRIDEiQ66HG4.

PTM databases

iPTMnetiQ66HG4.
PhosphoSitePlusiQ66HG4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007023.
GenevisibleiQ66HG4. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009221.

Structurei

3D structure databases

ProteinModelPortaliQ66HG4.
SMRiQ66HG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 82Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the aldose epimerase family.Curated

Phylogenomic databases

eggNOGiKOG1604. Eukaryota.
COG2017. LUCA.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ66HG4.
KOiK01785.
OMAiATWLSCK.
OrthoDBiEOG091G0COE.
PhylomeDBiQ66HG4.
TreeFamiTF324207.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiView protein in InterPro
IPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_sf_dom.
IPR014718. GH-type_carb-bd.
PfamiView protein in Pfam
PF01263. Aldose_epim. 1 hit.
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiView protein in PROSITE
PS00545. ALDOSE_1_EPIMERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66HG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG
60 70 80 90 100
KASDVVLGFA ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN
110 120 130 140 150
REPNSLHGGF RGFDKVLWTP QVLSNGVQFS RVSPDGEEGY PGELKVWVTY
160 170 180 190 200
TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPDIY DHEVTIAADA
210 220 230 240 250
YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH GFDHNFCLKE
260 270 280 290 300
SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK
310 320 330 340
HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA
Length:342
Mass (Da):37,893
Last modified:October 11, 2004 - v1
Checksum:i2168267DCA6D44C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081876 mRNA. Translation: AAH81876.1.
RefSeqiNP_001007705.1. NM_001007704.1.
UniGeneiRn.83639.

Genome annotation databases

EnsembliENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneIDi313843.
KEGGirno:313843.
UCSCiRGD:1359459. rat.

Entry informationi

Entry nameiGALM_RAT
AccessioniPrimary (citable) accession number: Q66HG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families