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Q66HG4

- GALM_RAT

UniProt

Q66HG4 - GALM_RAT

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Protein
Aldose 1-epimerase
Gene
Galm
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton donor By similarity
Binding sitei243 – 2431Substrate By similarity
Active sitei307 – 3071Proton acceptor By similarity

GO - Molecular functioni

  1. aldose 1-epimerase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4127-MONOMER.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:Galm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1359459. Galm.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 342341Aldose 1-epimerase
PRO_0000197437Add
BLAST

Proteomic databases

PaxDbiQ66HG4.
PRIDEiQ66HG4.

PTM databases

PhosphoSiteiQ66HG4.

Expressioni

Gene expression databases

GenevestigatoriQ66HG4.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009221.

Structurei

3D structure databases

ProteinModelPortaliQ66HG4.
SMRiQ66HG4. Positions 1-342.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarity

Sequence similaritiesi

Belongs to the aldose epimerase family.

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ66HG4.
KOiK01785.
OMAiKRFCARV.
OrthoDBiEOG7V7666.
PhylomeDBiQ66HG4.
TreeFamiTF324207.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG4-1 [UniParc]FASTAAdd to Basket

« Hide

MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG    50
KASDVVLGFA ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN 100
REPNSLHGGF RGFDKVLWTP QVLSNGVQFS RVSPDGEEGY PGELKVWVTY 150
TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPDIY DHEVTIAADA 200
YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH GFDHNFCLKE 250
SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK 300
HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA 342
Length:342
Mass (Da):37,893
Last modified:October 11, 2004 - v1
Checksum:i2168267DCA6D44C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081876 mRNA. Translation: AAH81876.1.
RefSeqiNP_001007705.1. NM_001007704.1.
UniGeneiRn.83639.

Genome annotation databases

EnsembliENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneIDi313843.
KEGGirno:313843.
UCSCiRGD:1359459. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081876 mRNA. Translation: AAH81876.1 .
RefSeqi NP_001007705.1. NM_001007704.1.
UniGenei Rn.83639.

3D structure databases

ProteinModelPortali Q66HG4.
SMRi Q66HG4. Positions 1-342.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009221.

PTM databases

PhosphoSitei Q66HG4.

Proteomic databases

PaxDbi Q66HG4.
PRIDEi Q66HG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009221 ; ENSRNOP00000009221 ; ENSRNOG00000007023 .
GeneIDi 313843.
KEGGi rno:313843.
UCSCi RGD:1359459. rat.

Organism-specific databases

CTDi 130589.
RGDi 1359459. Galm.

Phylogenomic databases

eggNOGi COG2017.
GeneTreei ENSGT00510000047589.
HOGENOMi HOG000072798.
HOVERGENi HBG051697.
InParanoidi Q66HG4.
KOi K01785.
OMAi KRFCARV.
OrthoDBi EOG7V7666.
PhylomeDBi Q66HG4.
TreeFami TF324207.

Enzyme and pathway databases

UniPathwayi UPA00242 .
BioCyci RETL1328306-WGS:GSTH-4127-MONOMER.

Miscellaneous databases

NextBioi 666902.
PROi Q66HG4.

Gene expression databases

Genevestigatori Q66HG4.

Family and domain databases

Gene3Di 2.70.98.10. 1 hit.
InterProi IPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view ]
Pfami PF01263. Aldose_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF005096. GALM. 1 hit.
SUPFAMi SSF74650. SSF74650. 1 hit.
PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 69-78 AND 146-162, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiGALM_RAT
AccessioniPrimary (citable) accession number: Q66HG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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