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Q66HG4

- GALM_RAT

UniProt

Q66HG4 - GALM_RAT

Protein

Aldose 1-epimerase

Gene

Galm

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.By similarity

    Catalytic activityi

    Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761Proton donorPROSITE-ProRule annotation
    Binding sitei243 – 2431SubstrateBy similarity
    Active sitei307 – 3071Proton acceptorBy similarity

    GO - Molecular functioni

    1. aldose 1-epimerase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-4127-MONOMER.
    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose 1-epimerase (EC:5.1.3.3)
    Alternative name(s):
    Galactose mutarotase
    Gene namesi
    Name:Galm
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi1359459. Galm.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 342341Aldose 1-epimerasePRO_0000197437Add
    BLAST

    Proteomic databases

    PaxDbiQ66HG4.
    PRIDEiQ66HG4.

    PTM databases

    PhosphoSiteiQ66HG4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ66HG4.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66HG4.
    SMRiQ66HG4. Positions 1-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 822Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the aldose epimerase family.Curated

    Phylogenomic databases

    eggNOGiCOG2017.
    GeneTreeiENSGT00510000047589.
    HOGENOMiHOG000072798.
    HOVERGENiHBG051697.
    InParanoidiQ66HG4.
    KOiK01785.
    OMAiKRFCARV.
    OrthoDBiEOG7V7666.
    PhylomeDBiQ66HG4.
    TreeFamiTF324207.

    Family and domain databases

    Gene3Di2.70.98.10. 1 hit.
    InterProiIPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view]
    PfamiPF01263. Aldose_epim. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005096. GALM. 1 hit.
    SUPFAMiSSF74650. SSF74650. 1 hit.
    PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66HG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG    50
    KASDVVLGFA ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN 100
    REPNSLHGGF RGFDKVLWTP QVLSNGVQFS RVSPDGEEGY PGELKVWVTY 150
    TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPDIY DHEVTIAADA 200
    YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH GFDHNFCLKE 250
    SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK 300
    HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA 342
    Length:342
    Mass (Da):37,893
    Last modified:October 11, 2004 - v1
    Checksum:i2168267DCA6D44C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081876 mRNA. Translation: AAH81876.1.
    RefSeqiNP_001007705.1. NM_001007704.1.
    UniGeneiRn.83639.

    Genome annotation databases

    EnsembliENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
    GeneIDi313843.
    KEGGirno:313843.
    UCSCiRGD:1359459. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081876 mRNA. Translation: AAH81876.1 .
    RefSeqi NP_001007705.1. NM_001007704.1.
    UniGenei Rn.83639.

    3D structure databases

    ProteinModelPortali Q66HG4.
    SMRi Q66HG4. Positions 1-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009221.

    PTM databases

    PhosphoSitei Q66HG4.

    Proteomic databases

    PaxDbi Q66HG4.
    PRIDEi Q66HG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009221 ; ENSRNOP00000009221 ; ENSRNOG00000007023 .
    GeneIDi 313843.
    KEGGi rno:313843.
    UCSCi RGD:1359459. rat.

    Organism-specific databases

    CTDi 130589.
    RGDi 1359459. Galm.

    Phylogenomic databases

    eggNOGi COG2017.
    GeneTreei ENSGT00510000047589.
    HOGENOMi HOG000072798.
    HOVERGENi HBG051697.
    InParanoidi Q66HG4.
    KOi K01785.
    OMAi KRFCARV.
    OrthoDBi EOG7V7666.
    PhylomeDBi Q66HG4.
    TreeFami TF324207.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .
    BioCyci RETL1328306-WGS:GSTH-4127-MONOMER.

    Miscellaneous databases

    NextBioi 666902.
    PROi Q66HG4.

    Gene expression databases

    Genevestigatori Q66HG4.

    Family and domain databases

    Gene3Di 2.70.98.10. 1 hit.
    InterProi IPR018052. Ald1_epimerase_CS.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view ]
    Pfami PF01263. Aldose_epim. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005096. GALM. 1 hit.
    SUPFAMi SSF74650. SSF74650. 1 hit.
    PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 69-78 AND 146-162, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiGALM_RAT
    AccessioniPrimary (citable) accession number: Q66HG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3