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Protein

Aldose 1-epimerase

Gene

Galm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).By similarity

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Pathway:ihexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton donorPROSITE-ProRule annotation
Binding sitei243 – 2431SubstrateBy similarity
Active sitei307 – 3071Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4127-MONOMER.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:Galm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359459. Galm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 342341Aldose 1-epimerasePRO_0000197437Add
BLAST

Proteomic databases

PaxDbiQ66HG4.
PRIDEiQ66HG4.

PTM databases

PhosphoSiteiQ66HG4.

Expressioni

Gene expression databases

GenevisibleiQ66HG4. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009221.

Structurei

3D structure databases

ProteinModelPortaliQ66HG4.
SMRiQ66HG4. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the aldose epimerase family.Curated

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ66HG4.
KOiK01785.
OMAiDADCVAE.
OrthoDBiEOG7V7666.
PhylomeDBiQ66HG4.
TreeFamiTF324207.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG
60 70 80 90 100
KASDVVLGFA ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN
110 120 130 140 150
REPNSLHGGF RGFDKVLWTP QVLSNGVQFS RVSPDGEEGY PGELKVWVTY
160 170 180 190 200
TLDGGELVVN YRAQASQTTP VNLTNHSYFN LAGQGSPDIY DHEVTIAADA
210 220 230 240 250
YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH GFDHNFCLKE
260 270 280 290 300
SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK
310 320 330 340
HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA
Length:342
Mass (Da):37,893
Last modified:October 11, 2004 - v1
Checksum:i2168267DCA6D44C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081876 mRNA. Translation: AAH81876.1.
RefSeqiNP_001007705.1. NM_001007704.1.
UniGeneiRn.83639.

Genome annotation databases

EnsembliENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneIDi313843.
KEGGirno:313843.
UCSCiRGD:1359459. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081876 mRNA. Translation: AAH81876.1.
RefSeqiNP_001007705.1. NM_001007704.1.
UniGeneiRn.83639.

3D structure databases

ProteinModelPortaliQ66HG4.
SMRiQ66HG4. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009221.

PTM databases

PhosphoSiteiQ66HG4.

Proteomic databases

PaxDbiQ66HG4.
PRIDEiQ66HG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneIDi313843.
KEGGirno:313843.
UCSCiRGD:1359459. rat.

Organism-specific databases

CTDi130589.
RGDi1359459. Galm.

Phylogenomic databases

eggNOGiCOG2017.
GeneTreeiENSGT00510000047589.
HOGENOMiHOG000072798.
HOVERGENiHBG051697.
InParanoidiQ66HG4.
KOiK01785.
OMAiDADCVAE.
OrthoDBiEOG7V7666.
PhylomeDBiQ66HG4.
TreeFamiTF324207.

Enzyme and pathway databases

UniPathwayiUPA00242.
BioCyciRETL1328306-WGS:GSTH-4127-MONOMER.

Miscellaneous databases

NextBioi666902.
PROiQ66HG4.

Gene expression databases

GenevisibleiQ66HG4. RN.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF005096. GALM. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 69-78 AND 146-162, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiGALM_RAT
AccessioniPrimary (citable) accession number: Q66HG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.