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Q66HG4 (GALM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose 1-epimerase

EC=5.1.3.3
Alternative name(s):
Galactose mutarotase
Gene names
Name:Galm
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.

Catalytic activity

Alpha-D-glucose = beta-D-glucose.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the aldose epimerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processhexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldose 1-epimerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 342341Aldose 1-epimerase
PRO_0000197437

Regions

Region81 – 822Substrate binding By similarity

Sites

Active site1761Proton donor By similarity
Active site3071Proton acceptor By similarity
Binding site2431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66HG4 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2168267DCA6D44C3

FASTA34237,893
        10         20         30         40         50         60 
MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG KASDVVLGFA 

        70         80         90        100        110        120 
ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN REPNSLHGGF RGFDKVLWTP 

       130        140        150        160        170        180 
QVLSNGVQFS RVSPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQTTP VNLTNHSYFN 

       190        200        210        220        230        240 
LAGQGSPDIY DHEVTIAADA YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH 

       250        260        270        280        290        300 
GFDHNFCLKE SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK 

       310        320        330        340 
HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 69-78 AND 146-162, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081876 mRNA. Translation: AAH81876.1.
RefSeqNP_001007705.1. NM_001007704.1.
UniGeneRn.83639.

3D structure databases

ProteinModelPortalQ66HG4.
SMRQ66HG4. Positions 1-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009221.

PTM databases

PhosphoSiteQ66HG4.

Proteomic databases

PaxDbQ66HG4.
PRIDEQ66HG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneID313843.
KEGGrno:313843.
UCSCRGD:1359459. rat.

Organism-specific databases

CTD130589.
RGD1359459. Galm.

Phylogenomic databases

eggNOGCOG2017.
GeneTreeENSGT00510000047589.
HOGENOMHOG000072798.
HOVERGENHBG051697.
InParanoidQ66HG4.
KOK01785.
OMAKRFCARV.
OrthoDBEOG7V7666.
PhylomeDBQ66HG4.
TreeFamTF324207.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-4127-MONOMER.
UniPathwayUPA00242.

Gene expression databases

GenevestigatorQ66HG4.

Family and domain databases

Gene3D2.70.98.10. 1 hit.
InterProIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFPIRSF005096. GALM. 1 hit.
SUPFAMSSF74650. SSF74650. 1 hit.
PROSITEPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio666902.
PROQ66HG4.

Entry information

Entry nameGALM_RAT
AccessionPrimary (citable) accession number: Q66HG4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways