Q66HG4 (GALM_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldose 1-epimerase
EC=5.1.3.3

Alternative name(s):
Galactose mutarotase

Gene names

Name:

Galm

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.
Catalytic activity	Alpha-D-glucose = beta-D-glucose.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the aldose epimerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	hexose metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aldose 1-epimerase activity Inferred from electronic annotation. Source: EC carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Aldose 1-epimerase		PRO_0000197437
Regions
	Region	81 – 82	2	Substrate binding By similarity
Sites
	Active site	176	1	Proton donor By similarity
	Active site	307	1	Proton acceptor By similarity
	Binding site	243	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66HG4 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 2168267DCA6D44C3	FASTA	342	37,893
	10 20 30 40 50 60 MVSVTRTVFG ELPSGGGAVE KFQLRSDQLN VDIISWGCTI TALQVKDRQG KASDVVLGFA 70 80 90 100 110 120 ELEGYLQKQP YFGAVVGRVA NRIAKGRFTV DGKEYHLPIN REPNSLHGGF RGFDKVLWTP 130 140 150 160 170 180 QVLSNGVQFS RVSPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQTTP VNLTNHSYFN 190 200 210 220 230 240 LAGQGSPDIY DHEVTIAADA YLPVDETLIP TGVIAPVEGT AFDLRKPVEL GKHLQSYHIH 250 260 270 280 290 300 GFDHNFCLKE SKEKKFCARV HHAASGRILE VYTTQPGVQF YTGNFLDGTL KGKSGEVYPK 310 320 330 340 HSGFCLETQN WPDAVNQPQF PPILLRPGEE YNHTTWFKFS VA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 69-78 AND 146-162, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081876 mRNA. Translation: AAH81876.1.
IPI	IPI00360056.
RefSeq	NP_001007705.1. NM_001007704.1.
UniGene	Rn.83639.
3D structure databases
ProteinModelPortal	Q66HG4.
SMR	Q66HG4. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000009221.
PTM databases
PhosphoSite	Q66HG4.
Proteomic databases
PaxDb	Q66HG4.
PRIDE	Q66HG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000009221; ENSRNOP00000009221; ENSRNOG00000007023.
GeneID	313843.
KEGG	rno:313843.
UCSC	RGD:1359459. rat.
Organism-specific databases
CTD	130589.
RGD	1359459. Galm.
Phylogenomic databases
eggNOG	COG2017.
GeneTree	ENSGT00510000047589.
HOGENOM	HOG000072798.
HOVERGEN	HBG051697.
InParanoid	Q66HG4.
KO	K01785.
OMA	NHTTWFK.
OrthoDB	EOG4HHP31.
Enzyme and pathway databases
UniPathway	UPA00242.
Gene expression databases
Genevestigator	Q66HG4.
GermOnline	ENSRNOG00000007023. Rattus norvegicus.
Family and domain databases
Gene3D	2.70.98.10. 1 hit.
InterPro	IPR018052. Ald1_epimerase_CS. IPR015443. Aldose_1-epimerase. IPR008183. Aldose_1/G6P_1-epimerase. IPR011013. Gal_mutarotase_SF_dom. IPR014718. Glyco_hydro-type_carb-bd_sub. [Graphical view]
PANTHER	PTHR10091. PTHR10091. 1 hit.
Pfam	PF01263. Aldose_epim. 1 hit. [Graphical view]
PIRSF	PIRSF005096. GALM. 1 hit.
SUPFAM	SSF74650. Gal_mut_like. 1 hit.
PROSITE	PS00545. ALDOSE_1_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	666902.

Entry information

Entry name

GALM_RAT

Accession

Primary (citable) accession number: Q66HG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program