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Protein

Beta-Ala-His dipeptidase

Gene

Cndp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi107 – 1071Zinc 2By similarity
Active sitei109 – 1091By similarity
Metal bindingi140 – 1401Zinc 1By similarity
Metal bindingi140 – 1401Zinc 2By similarity
Active sitei174 – 1741Proton acceptorBy similarity
Metal bindingi175 – 1751Zinc 1By similarity
Metal bindingi203 – 2031Zinc 2By similarity
Metal bindingi453 – 4531Zinc 1By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-Ala-His dipeptidase (EC:3.4.13.20)
Alternative name(s):
CNDP dipeptidase 1
Carnosine dipeptidase 1
Gene namesi
Name:Cndp1
Synonyms:Cn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1359493. Cndp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Beta-Ala-His dipeptidasePRO_0000250531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HG3.
PRIDEiQ66HG3.

PTM databases

iPTMnetiQ66HG3.
PhosphoSiteiQ66HG3.

Expressioni

Tissue specificityi

Detected exclusively in kidney.1 Publication

Gene expression databases

GenevisibleiQ66HG3. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034652.

Structurei

3D structure databases

ProteinModelPortaliQ66HG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2276. Eukaryota.
COG0624. LUCA.
GeneTreeiENSGT00390000009682.
HOGENOMiHOG000216709.
HOVERGENiHBG051103.
InParanoidiQ66HG3.
KOiK05604.
OMAiWNYIEGT.
OrthoDBiEOG7JHM55.
PhylomeDBiQ66HG3.
TreeFamiTF300633.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR017153. GSH_degradosome_DUG1.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037242. CNDP_dipeptidase. 1 hit.
PROSITEiPS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPPHSGTL EKLFQYIDLH QDEFVQTLKE WVAIESDSVQ PMPRLRQELF
60 70 80 90 100
RMMALAADKL RNLGARVDSV DLGSQQMPDG QSLPTPPIIL AELGNDPKKP
110 120 130 140 150
SVCFYGHLDV QPAQKEDGWL TDPYTLTEVD GKLYGRGATD NKGPVLAWIN
160 170 180 190 200
AVSTFRALQQ DLPVNVKFIL EGMEEAGSVA LEELVKREKD NFFSGVDYIV
210 220 230 240 250
ISDNLWLSQK KPALTCGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD
260 270 280 290 300
LVALLGSLVD SSGHILVPGI YDQMAPITEE EKTMYENIDL DLEEYQKSSR
310 320 330 340 350
VERFLFDTKE ELLTHLWRYP SLSIHGIEGA FDEPGTKTVI PGRVLGKFSI
360 370 380 390 400
RLVPHMTPSV VETQVTQHLE AVFSKRNSFN KMAVSMVLGL QPWTANINGT
410 420 430 440 450
QYLAARRAIQ TVFGVDPDMI QDGSTIPIAK IFQDITQKSV MMLPLGAVDD
460 470 480 490
GEHSQNEKIN RWNYIQGSKL FAAFFLELSK LHSGQQVPSG AF
Length:492
Mass (Da):54,928
Last modified:October 11, 2004 - v1
Checksum:iEF8DAE8C15BF06F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081877 mRNA. Translation: AAH81877.1.
RefSeqiNP_001007688.1. NM_001007687.1.
XP_006255071.1. XM_006255009.2.
XP_008770357.1. XM_008772135.1.
UniGeneiRn.15548.

Genome annotation databases

EnsembliENSRNOT00000034970; ENSRNOP00000034652; ENSRNOG00000027739.
GeneIDi307212.
KEGGirno:307212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081877 mRNA. Translation: AAH81877.1.
RefSeqiNP_001007688.1. NM_001007687.1.
XP_006255071.1. XM_006255009.2.
XP_008770357.1. XM_008772135.1.
UniGeneiRn.15548.

3D structure databases

ProteinModelPortaliQ66HG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034652.

PTM databases

iPTMnetiQ66HG3.
PhosphoSiteiQ66HG3.

Proteomic databases

PaxDbiQ66HG3.
PRIDEiQ66HG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034970; ENSRNOP00000034652; ENSRNOG00000027739.
GeneIDi307212.
KEGGirno:307212.

Organism-specific databases

CTDi84735.
RGDi1359493. Cndp1.

Phylogenomic databases

eggNOGiKOG2276. Eukaryota.
COG0624. LUCA.
GeneTreeiENSGT00390000009682.
HOGENOMiHOG000216709.
HOVERGENiHBG051103.
InParanoidiQ66HG3.
KOiK05604.
OMAiWNYIEGT.
OrthoDBiEOG7JHM55.
PhylomeDBiQ66HG3.
TreeFamiTF300633.

Miscellaneous databases

NextBioi657098.
PROiQ66HG3.

Gene expression databases

GenevisibleiQ66HG3. RN.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR017153. GSH_degradosome_DUG1.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037242. CNDP_dipeptidase. 1 hit.
PROSITEiPS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase."
    Teufel M., Saudek V., Ledig J.P., Bernhardt A., Boularand S., Carreau A., Cairns N.J., Carter C., Cowley D.J., Duverger D., Ganzhorn A.J., Guenet C., Heintzelmann B., Laucher V., Sauvage C., Smirnova T.
    J. Biol. Chem. 278:6521-6531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNDP1_RAT
AccessioniPrimary (citable) accession number: Q66HG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2004
Last modified: January 20, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to human counterpart, it lacks a signal sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.