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Protein

Beta-Ala-His dipeptidase

Gene

Cndp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

In contrast to human counterpart, it lacks a signal sequence.Curated

Catalytic activityi

Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107Zinc 2By similarity1
Active sitei109By similarity1
Metal bindingi140Zinc 1By similarity1
Metal bindingi140Zinc 2By similarity1
Active sitei174Proton acceptorBy similarity1
Metal bindingi175Zinc 1By similarity1
Metal bindingi203Zinc 2By similarity1
Metal bindingi453Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-Ala-His dipeptidase (EC:3.4.13.20)
Alternative name(s):
CNDP dipeptidase 1
Carnosine dipeptidase 1
Gene namesi
Name:Cndp1
Synonyms:Cn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1359493 Cndp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505311 – 492Beta-Ala-His dipeptidaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HG3
PRIDEiQ66HG3

PTM databases

iPTMnetiQ66HG3
PhosphoSitePlusiQ66HG3

Expressioni

Tissue specificityi

Detected exclusively in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000027739
GenevisibleiQ66HG3 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034652

Structurei

3D structure databases

ProteinModelPortaliQ66HG3
SMRiQ66HG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2276 Eukaryota
COG0624 LUCA
GeneTreeiENSGT00390000009682
HOGENOMiHOG000216709
HOVERGENiHBG051103
InParanoidiQ66HG3
KOiK05604
OMAiELFRMMA
OrthoDBiEOG091G05RU
PhylomeDBiQ66HG3
TreeFamiTF300633

Family and domain databases

CDDicd05676 M20_dipept_like_CNDP, 1 hit
InterProiView protein in InterPro
IPR001261 ArgE/DapE_CS
IPR017153 CNDP/DUG1
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
PIRSFiPIRSF037242 CNDP_dipeptidase, 1 hit
PROSITEiView protein in PROSITE
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q66HG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPPHSGTL EKLFQYIDLH QDEFVQTLKE WVAIESDSVQ PMPRLRQELF
60 70 80 90 100
RMMALAADKL RNLGARVDSV DLGSQQMPDG QSLPTPPIIL AELGNDPKKP
110 120 130 140 150
SVCFYGHLDV QPAQKEDGWL TDPYTLTEVD GKLYGRGATD NKGPVLAWIN
160 170 180 190 200
AVSTFRALQQ DLPVNVKFIL EGMEEAGSVA LEELVKREKD NFFSGVDYIV
210 220 230 240 250
ISDNLWLSQK KPALTCGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD
260 270 280 290 300
LVALLGSLVD SSGHILVPGI YDQMAPITEE EKTMYENIDL DLEEYQKSSR
310 320 330 340 350
VERFLFDTKE ELLTHLWRYP SLSIHGIEGA FDEPGTKTVI PGRVLGKFSI
360 370 380 390 400
RLVPHMTPSV VETQVTQHLE AVFSKRNSFN KMAVSMVLGL QPWTANINGT
410 420 430 440 450
QYLAARRAIQ TVFGVDPDMI QDGSTIPIAK IFQDITQKSV MMLPLGAVDD
460 470 480 490
GEHSQNEKIN RWNYIQGSKL FAAFFLELSK LHSGQQVPSG AF
Length:492
Mass (Da):54,928
Last modified:October 11, 2004 - v1
Checksum:iEF8DAE8C15BF06F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081877 mRNA Translation: AAH81877.1
RefSeqiNP_001007688.1, NM_001007687.1
XP_006255071.1, XM_006255009.3
XP_008770357.1, XM_008772135.2
UniGeneiRn.15548

Genome annotation databases

EnsembliENSRNOT00000034970; ENSRNOP00000034652; ENSRNOG00000027739
GeneIDi307212
KEGGirno:307212

Similar proteinsi

Entry informationi

Entry nameiCNDP1_RAT
AccessioniPrimary (citable) accession number: Q66HG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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