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Protein

E3 ubiquitin-protein ligase RNF13

Gene

Rnf13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 282RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF13 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 13
Gene namesi
Name:Rnf13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1594062. Rnf13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 182LumenalSequence analysisAdd BLAST148
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 380CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000030736935 – 380E3 ubiquitin-protein ligase RNF13Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Auto-ubiquitinated.By similarity
N-glycosylated and also modified with chondroitin sulfate.By similarity

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ66HG0.
PRIDEiQ66HG0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029209.
GenevisibleiQ66HG0. RN.

Interactioni

Protein-protein interaction databases

BioGridi596506. 1 interactor.
STRINGi10116.ENSRNOP00000060441.

Structurei

3D structure databases

ProteinModelPortaliQ66HG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 160PAAdd BLAST97

Domaini

The RING-type zinc finger domain is required for E3 ligase activity.By similarity

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 282RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG4628. Eukaryota.
ENOG410Z5DF. LUCA.
GeneTreeiENSGT00760000119057.
HOVERGENiHBG063762.
InParanoidiQ66HG0.
KOiK15692.
OMAiNMTESSE.
OrthoDBiEOG091G08WC.
PhylomeDBiQ66HG0.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFED
60 70 80 90 100
LPARFGYRLP AEGLKGFLIN SKPENACEPI VPPPLKDNSS GTFIVLIRRL
110 120 130 140 150
DCNFDIKVLN AQRAGYKAAI VHNVDSDDLI SMGSNDIDIL KKIDIPSVFI
160 170 180 190 200
GESSANSLKD EFTYEKGGHV ILVPELSLPL EYYLIPFLII VGICLILIVI
210 220 230 240 250
FMITKFVQDR HRNRRNRLRK DQLKKLPVHK FKKGDEYDVC AICLEEYEDG
260 270 280 290 300
DKLRILPCSH AYHCKCVDPW LTKTKKTCPV CKQKVVPSQG DSDSDTDSSQ
310 320 330 340 350
EENQVSEHTP LLPPSASART QSFGSLSESH SHHMTESSDY EDDDNEETDS
360 370 380
SDADNEITDH SVVVQLQPNG EPDYNIANTV
Length:380
Mass (Da):42,585
Last modified:October 11, 2004 - v1
Checksum:i1BC463BCB34C4309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081881 mRNA. Translation: AAH81881.1.
RefSeqiNP_001102914.1. NM_001109444.2.
UniGeneiRn.17153.

Genome annotation databases

EnsembliENSRNOT00000068606; ENSRNOP00000060441; ENSRNOG00000029209.
GeneIDi681578.
KEGGirno:681578.
UCSCiRGD:1594062. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081881 mRNA. Translation: AAH81881.1.
RefSeqiNP_001102914.1. NM_001109444.2.
UniGeneiRn.17153.

3D structure databases

ProteinModelPortaliQ66HG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi596506. 1 interactor.
STRINGi10116.ENSRNOP00000060441.

Proteomic databases

PaxDbiQ66HG0.
PRIDEiQ66HG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068606; ENSRNOP00000060441; ENSRNOG00000029209.
GeneIDi681578.
KEGGirno:681578.
UCSCiRGD:1594062. rat.

Organism-specific databases

CTDi11342.
RGDi1594062. Rnf13.

Phylogenomic databases

eggNOGiKOG4628. Eukaryota.
ENOG410Z5DF. LUCA.
GeneTreeiENSGT00760000119057.
HOVERGENiHBG063762.
InParanoidiQ66HG0.
KOiK15692.
OMAiNMTESSE.
OrthoDBiEOG091G08WC.
PhylomeDBiQ66HG0.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ66HG0.

Gene expression databases

BgeeiENSRNOG00000029209.
GenevisibleiQ66HG0. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF13_RAT
AccessioniPrimary (citable) accession number: Q66HG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.