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Q66HF9 (LRRF1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Leucine-rich repeat flightless-interacting protein 1
Short name=LRR FLII-interacting protein 1
Gene names
Name:Lrrfip1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding By similarity. Ref.2

Subunit structure

Interacts with FLII By similarity. Interacts with MYD88 By similarity. Competes with FLII for MyD88-binding, even in the absence of LPS By similarity.

Subcellular location

Nucleus. Cytoplasm By similarity.

Induction

Up-regulated after artery wall injury (at protein level). Ref.2

Sequence similarities

Belongs to the LRRFIP family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   LigandDNA-binding
   Molecular functionRepressor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 738737Leucine-rich repeat flightless-interacting protein 1
PRO_0000248394

Regions

Region479 – 580102DNA-binding By similarity
Coiled coil94 – 194101 Potential
Compositional bias563 – 57614Lys-rich

Amino acid modifications

Modified residue21N-acetylthreonine By similarity
Modified residue161Phosphoserine By similarity
Modified residue831Phosphoserine By similarity
Modified residue881Phosphoserine By similarity
Modified residue911Phosphothreonine By similarity
Modified residue3021Phosphoserine By similarity
Modified residue5511Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66HF9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 10D6F003160948B7

FASTA73880,019
        10         20         30         40         50         60 
MTSPEGAQNK EIDCLSPEAQ RLAEARLAAK RAARAEAREI RMKELERQQK EVEERPDKDF 

        70         80         90        100        110        120 
AEKGSRNMPS LSAATLASLG GTSSRRGSGD TSISMDTEAS IREIKDSLAE VEEKYKKAMV 

       130        140        150        160        170        180 
SNAQLDNEKT NFMYQVDTLK DMLLELEEQL AESQRQYEEK NKEFEREKHA HSILQFQFAE 

       190        200        210        220        230        240 
VKEALRQREE MLEKHGIILN SEIATNGETS DTVNDVGYQA PTKITKEELN ALKAAGEGTL 

       250        260        270        280        290        300 
GKAKEVEVKK EIVEKVGQRE TLQDSEQEQP KLNTGKDCVD RGVLHPGEKA ENQRPVEDSA 

       310        320        330        340        350        360 
LSPGPLAGAK CEQEVQSQDQ ENTSILKSPE QIESHEVTNK SDSRDSNSPE PSSCRGGLDS 

       370        380        390        400        410        420 
EVSGPTALGI KNQSENSMDS QGKENQEDLG KGSFEPRPDH VLGQTPEIDK VSCTDSRGTG 

       430        440        450        460        470        480 
GNHLEDVVQA GDTIVEDQVG TMASAEQSKS MENHIGRSLN DGLGQSSERE LAHEAAELEE 

       490        500        510        520        530        540 
ALTQSSQAGG ENTVTEAEDA AVRDEKPLQA DVQATPAAPT VQSGHQDTTG PGSTDTKHTS 

       550        560        570        580        590        600 
PHAKERNKAK SEQQAEALDS PQKKTKNKKK KNKKKKAAAP METCKDANEE SSCQDPDVGD 

       610        620        630        640        650        660 
GEEEERVQAT DKKWAAETPE LKEDPQSRPS GKQNDAEEDS GPAEGPTDVL DQNSLQCADG 

       670        680        690        700        710        720 
DISPVGRKGP QRDASQIGGE EGLVPSQHPG QADEKGIEGH SVDNSDLSGE LGGFNSESGE 

       730 
QAREEVGNSK SKEDCTMS

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway.
Tissue: Kidney.
[2]"GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury."
Khachigian L.M., Santiago F.S., Rafty L.A., Chan O.L.-W., Delbridge G.J., Bobik A., Collins T., Johnson A.C.
Circ. Res. 84:1258-1267(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC081883 mRNA. Translation: AAH81883.1.
IPIIPI00471873.
RefSeqNP_001014291.1. NM_001014269.1.
UniGeneRn.153995.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000045021.

PTM databases

PhosphoSiteQ66HF9.

Proteomic databases

PaxDbQ66HF9.
PRIDEQ66HF9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000050191; ENSRNOP00000045021; ENSRNOG00000019892.
GeneID367314.
KEGGrno:367314.
UCSCRGD:1359548. rat.

Organism-specific databases

CTD9208.
RGD1359548. Lrrfip1.

Phylogenomic databases

eggNOGNOG296572.
GeneTreeENSGT00530000063564.
HOGENOMHOG000113391.
HOVERGENHBG081935.
InParanoidQ66HF9.
OMAAREEVGN.

Gene expression databases

ArrayExpressQ66HF9.
GenevestigatorQ66HF9.
GermOnlineENSRNOG00000019892. Rattus norvegicus.

Family and domain databases

InterProIPR019139. Leu-rich_rep_flightless-int_pr.
[Graphical view]
PANTHERPTHR19212. PTHR19212. 1 hit.
PfamPF09738. DUF2051. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio691097.

Entry information

Entry nameLRRF1_RAT
AccessionPrimary (citable) accession number: Q66HF9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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