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Protein

Leucine-rich repeat flightless-interacting protein 1

Gene

Lrrfip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 1
Short name:
LRR FLII-interacting protein 1
Gene namesi
Name:Lrrfip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359548. Lrrfip1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002483942 – 738Leucine-rich repeat flightless-interacting protein 1Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei302PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei348PhosphoserineBy similarity1
Modified residuei551PhosphoserineBy similarity1
Modified residuei560PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei701PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ66HF9.
PRIDEiQ66HF9.

PTM databases

iPTMnetiQ66HF9.
PhosphoSitePlusiQ66HF9.

Expressioni

Inductioni

Up-regulated after artery wall injury (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000019892.
GenevisibleiQ66HF9. RN.

Interactioni

Subunit structurei

Homodimer. May also form higher oligomers. Interacts with FLII (By similarity). Interacts with MYD88 (By similarity). Competes with FLII for MyD88-binding, even in the absence of LPS (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045021.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni479 – 580DNA-bindingBy similarityAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 194By similarityAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 576Lys-richAdd BLAST14

Domaini

The DNA-binding domain is intrinsically unstructured.By similarity
The coiled coil mediates dimerization.By similarity

Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2010. Eukaryota.
ENOG4111H1S. LUCA.
GeneTreeiENSGT00530000063564.
HOGENOMiHOG000113391.
HOVERGENiHBG081935.
InParanoidiQ66HF9.
OMAiAREEVGN.
OrthoDBiEOG091G0C5Y.
PhylomeDBiQ66HF9.
TreeFamiTF314109.

Family and domain databases

InterProiIPR019139. LRRFIP1/2.
[Graphical view]
PANTHERiPTHR19212. PTHR19212. 1 hit.
PfamiPF09738. LRRFIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPEGAQNK EIDCLSPEAQ RLAEARLAAK RAARAEAREI RMKELERQQK
60 70 80 90 100
EVEERPDKDF AEKGSRNMPS LSAATLASLG GTSSRRGSGD TSISMDTEAS
110 120 130 140 150
IREIKDSLAE VEEKYKKAMV SNAQLDNEKT NFMYQVDTLK DMLLELEEQL
160 170 180 190 200
AESQRQYEEK NKEFEREKHA HSILQFQFAE VKEALRQREE MLEKHGIILN
210 220 230 240 250
SEIATNGETS DTVNDVGYQA PTKITKEELN ALKAAGEGTL GKAKEVEVKK
260 270 280 290 300
EIVEKVGQRE TLQDSEQEQP KLNTGKDCVD RGVLHPGEKA ENQRPVEDSA
310 320 330 340 350
LSPGPLAGAK CEQEVQSQDQ ENTSILKSPE QIESHEVTNK SDSRDSNSPE
360 370 380 390 400
PSSCRGGLDS EVSGPTALGI KNQSENSMDS QGKENQEDLG KGSFEPRPDH
410 420 430 440 450
VLGQTPEIDK VSCTDSRGTG GNHLEDVVQA GDTIVEDQVG TMASAEQSKS
460 470 480 490 500
MENHIGRSLN DGLGQSSERE LAHEAAELEE ALTQSSQAGG ENTVTEAEDA
510 520 530 540 550
AVRDEKPLQA DVQATPAAPT VQSGHQDTTG PGSTDTKHTS PHAKERNKAK
560 570 580 590 600
SEQQAEALDS PQKKTKNKKK KNKKKKAAAP METCKDANEE SSCQDPDVGD
610 620 630 640 650
GEEEERVQAT DKKWAAETPE LKEDPQSRPS GKQNDAEEDS GPAEGPTDVL
660 670 680 690 700
DQNSLQCADG DISPVGRKGP QRDASQIGGE EGLVPSQHPG QADEKGIEGH
710 720 730
SVDNSDLSGE LGGFNSESGE QAREEVGNSK SKEDCTMS
Length:738
Mass (Da):80,019
Last modified:October 11, 2004 - v1
Checksum:i10D6F003160948B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081883 mRNA. Translation: AAH81883.1.
RefSeqiNP_001014291.1. NM_001014269.1.
UniGeneiRn.153995.
Rn.229120.

Genome annotation databases

EnsembliENSRNOT00000050191; ENSRNOP00000045021; ENSRNOG00000019892.
GeneIDi367314.
KEGGirno:367314.
UCSCiRGD:1359548. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081883 mRNA. Translation: AAH81883.1.
RefSeqiNP_001014291.1. NM_001014269.1.
UniGeneiRn.153995.
Rn.229120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045021.

PTM databases

iPTMnetiQ66HF9.
PhosphoSitePlusiQ66HF9.

Proteomic databases

PaxDbiQ66HF9.
PRIDEiQ66HF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050191; ENSRNOP00000045021; ENSRNOG00000019892.
GeneIDi367314.
KEGGirno:367314.
UCSCiRGD:1359548. rat.

Organism-specific databases

CTDi9208.
RGDi1359548. Lrrfip1.

Phylogenomic databases

eggNOGiKOG2010. Eukaryota.
ENOG4111H1S. LUCA.
GeneTreeiENSGT00530000063564.
HOGENOMiHOG000113391.
HOVERGENiHBG081935.
InParanoidiQ66HF9.
OMAiAREEVGN.
OrthoDBiEOG091G0C5Y.
PhylomeDBiQ66HF9.
TreeFamiTF314109.

Miscellaneous databases

PROiQ66HF9.

Gene expression databases

BgeeiENSRNOG00000019892.
GenevisibleiQ66HF9. RN.

Family and domain databases

InterProiIPR019139. LRRFIP1/2.
[Graphical view]
PANTHERiPTHR19212. PTHR19212. 1 hit.
PfamiPF09738. LRRFIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRF1_RAT
AccessioniPrimary (citable) accession number: Q66HF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.