Reviewed,
UniProtKB/Swiss-Prot Q66HF8 (AL1B1_RAT)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase X, mitochondrial EC=1.2.1.3 Alternative name(s): Aldehyde dehydrogenase family 1 member B1 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 519 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity. |
| Catalytic activity | An aldehyde + NAD+ + H2O = an acid + NADH. |
| Pathway | Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 19 | 19 | Mitochondrion Potential | ||||||
| Chain | 20 – 519 | 500 | Aldehyde dehydrogenase X, mitochondrial | PRO_0000271413 | |||||
Regions | |||||||||
| Nucleotide binding | 264 – 269 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 287 | 1 | Proton acceptor By similarity | ||||||
| Active site | 321 | 1 | Nucleophile By similarity | ||||||
| Site | 188 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [2] | Lubec G., Afjehi-Sadat L., Chen W.-Q. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 55-75; 162-174; 327-340 AND 444-453, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus and Spinal cord. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC081884 mRNA. Translation: AAH81884.1. |
| IPI | IPI00471872. |
| RefSeq | NP_001011975.1. |
| UniGene | Rn.12547 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ZUM based on UniProtKB P05091. |
| SMR | Q66HF8. Positions 27-519. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q66HF8. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000015281; ENSRNOP00000015282; ENSRNOG00000011497; Rattus norvegicus. [Genome view] |
| GeneID | 298079. |
| KEGG | rno:298079. |
| UCSC | NM_001011975. rat. |
Organism-specific databases | |
| CTD | 298079. |
| RGD | 1306737. Aldh1b1. |
Phylogenomic databases | |
| eggNOG | maNOG05395. |
| HOVERGEN | Q66HF8. |
| InParanoid | Q66HF8. |
| PhylomeDB | Q66HF8. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.3. 248. |
Gene expression databases | |
| ArrayExpress | Q66HF8. |
| Genevestigator | Q66HF8. |
Family and domain databases | |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 643122. |
Entry information
| Entry name | AL1B1_RAT | ||||||||
| Accession | Primary (citable) accession number: Q66HF8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


