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Q66HF8

- AL1B1_RAT

UniProt

Q66HF8 - AL1B1_RAT

Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei188 – 1881Transition state stabilizerBy similarity
    Active sitei287 – 2871Proton acceptorPROSITE-ProRule annotation
    Active sitei321 – 3211NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi264 – 2696NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase family 1 member B1
    Gene namesi
    Name:Aldh1b1
    Synonyms:Aldhx
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306737. Aldh1b1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
    BLAST
    Chaini20 – 519500Aldehyde dehydrogenase X, mitochondrialPRO_0000271413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531N6-acetyllysineBy similarity
    Modified residuei54 – 541N6-acetyllysine; alternateBy similarity
    Modified residuei54 – 541N6-succinyllysine; alternateBy similarity
    Modified residuei366 – 3661N6-acetyllysine; alternateBy similarity
    Modified residuei366 – 3661N6-succinyllysine; alternateBy similarity
    Modified residuei385 – 3851N6-acetyllysine; alternateBy similarity
    Modified residuei385 – 3851N6-succinyllysine; alternateBy similarity
    Modified residuei401 – 4011N6-acetyllysine; alternateBy similarity
    Modified residuei401 – 4011N6-succinyllysine; alternateBy similarity
    Modified residuei428 – 4281N6-acetyllysine; alternateBy similarity
    Modified residuei428 – 4281N6-succinyllysine; alternateBy similarity
    Modified residuei431 – 4311N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ66HF8.
    PRIDEiQ66HF8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ66HF8.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66HF8.
    SMRiQ66HF8. Positions 27-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ66HF8.
    KOiK00128.
    PhylomeDBiQ66HF8.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66HF8-1 [UniParc]FASTAAdd to Basket

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    MLNARFLVPR LLCLQGRTTS YSTAAALPNP IPNPEIRYNQ LFINNEWHDA    50
    VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVRAAREAFR LGSPWRRMDA 100
    SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY 150
    LAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP 200
    ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA 250
    IAQHMDVDKV AFTGSTEVGH LIQKAAGDSN LKRVTLELGG KSPSIVLADA 300
    DMDHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYHEFLER TVEKAKKRKV 350
    GNPFELDTQQ GPQVDKEQFE KILGYIRLGQ KEGAKLLCGG ERFGERGFFI 400
    KPTVFGNVQD DMRIAREEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV 450
    FTRDLDKALY FSQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG 500
    LKAYTEVKTV TIKVSEKNS 519
    Length:519
    Mass (Da):57,625
    Last modified:October 11, 2004 - v1
    Checksum:i6D25E0E806F8EA50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081884 mRNA. Translation: AAH81884.1.
    RefSeqiNP_001011975.1. NM_001011975.1.
    UniGeneiRn.12547.

    Genome annotation databases

    GeneIDi298079.
    KEGGirno:298079.
    UCSCiRGD:1306737. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081884 mRNA. Translation: AAH81884.1 .
    RefSeqi NP_001011975.1. NM_001011975.1.
    UniGenei Rn.12547.

    3D structure databases

    ProteinModelPortali Q66HF8.
    SMRi Q66HF8. Positions 27-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015282.

    Proteomic databases

    PaxDbi Q66HF8.
    PRIDEi Q66HF8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 298079.
    KEGGi rno:298079.
    UCSCi RGD:1306737. rat.

    Organism-specific databases

    CTDi 219.
    RGDi 1306737. Aldh1b1.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q66HF8.
    KOi K00128.
    PhylomeDBi Q66HF8.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Miscellaneous databases

    NextBioi 643122.

    Gene expression databases

    Genevestigatori Q66HF8.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 55-75; 162-174; 327-340 AND 444-453, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus and Spinal cord.

    Entry informationi

    Entry nameiAL1B1_RAT
    AccessioniPrimary (citable) accession number: Q66HF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3