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Q66HF8

- AL1B1_RAT

UniProt

Q66HF8 - AL1B1_RAT

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Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity.By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei188 – 1881Transition state stabilizerBy similarity
Active sitei287 – 2871Proton acceptorPROSITE-ProRule annotation
Active sitei321 – 3211NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2696NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase family 1 member B1
Gene namesi
Name:Aldh1b1
Synonyms:Aldhx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306737. Aldh1b1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
BLAST
Chaini20 – 519500Aldehyde dehydrogenase X, mitochondrialPRO_0000271413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysine; alternateBy similarity
Modified residuei54 – 541N6-succinyllysine; alternateBy similarity
Modified residuei366 – 3661N6-acetyllysine; alternateBy similarity
Modified residuei366 – 3661N6-succinyllysine; alternateBy similarity
Modified residuei385 – 3851N6-acetyllysine; alternateBy similarity
Modified residuei385 – 3851N6-succinyllysine; alternateBy similarity
Modified residuei401 – 4011N6-acetyllysine; alternateBy similarity
Modified residuei401 – 4011N6-succinyllysine; alternateBy similarity
Modified residuei428 – 4281N6-acetyllysine; alternateBy similarity
Modified residuei428 – 4281N6-succinyllysine; alternateBy similarity
Modified residuei431 – 4311N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ66HF8.
PRIDEiQ66HF8.

Expressioni

Gene expression databases

GenevestigatoriQ66HF8.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015282.

Structurei

3D structure databases

ProteinModelPortaliQ66HF8.
SMRiQ66HF8. Positions 27-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ66HF8.
KOiK00128.
PhylomeDBiQ66HF8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNARFLVPR LLCLQGRTTS YSTAAALPNP IPNPEIRYNQ LFINNEWHDA
60 70 80 90 100
VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVRAAREAFR LGSPWRRMDA
110 120 130 140 150
SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY
160 170 180 190 200
LAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP
210 220 230 240 250
ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA
260 270 280 290 300
IAQHMDVDKV AFTGSTEVGH LIQKAAGDSN LKRVTLELGG KSPSIVLADA
310 320 330 340 350
DMDHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYHEFLER TVEKAKKRKV
360 370 380 390 400
GNPFELDTQQ GPQVDKEQFE KILGYIRLGQ KEGAKLLCGG ERFGERGFFI
410 420 430 440 450
KPTVFGNVQD DMRIAREEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV
460 470 480 490 500
FTRDLDKALY FSQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG
510
LKAYTEVKTV TIKVSEKNS
Length:519
Mass (Da):57,625
Last modified:October 11, 2004 - v1
Checksum:i6D25E0E806F8EA50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081884 mRNA. Translation: AAH81884.1.
RefSeqiNP_001011975.1. NM_001011975.1.
UniGeneiRn.12547.

Genome annotation databases

GeneIDi298079.
KEGGirno:298079.
UCSCiRGD:1306737. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081884 mRNA. Translation: AAH81884.1 .
RefSeqi NP_001011975.1. NM_001011975.1.
UniGenei Rn.12547.

3D structure databases

ProteinModelPortali Q66HF8.
SMRi Q66HF8. Positions 27-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015282.

Proteomic databases

PaxDbi Q66HF8.
PRIDEi Q66HF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 298079.
KEGGi rno:298079.
UCSCi RGD:1306737. rat.

Organism-specific databases

CTDi 219.
RGDi 1306737. Aldh1b1.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q66HF8.
KOi K00128.
PhylomeDBi Q66HF8.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Miscellaneous databases

NextBioi 643122.

Gene expression databases

Genevestigatori Q66HF8.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 55-75; 162-174; 327-340 AND 444-453, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiAL1B1_RAT
AccessioniPrimary (citable) accession number: Q66HF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3