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Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity).By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Transition state stabilizerBy similarity1
Active sitei287Proton acceptorPROSITE-ProRule annotation1
Active sitei321NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase family 1 member B1
Gene namesi
Name:Aldh1b1
Synonyms:Aldhx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306737. Aldh1b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000027141320 – 519Aldehyde dehydrogenase X, mitochondrialAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysine; alternateBy similarity1
Modified residuei54N6-succinyllysine; alternateBy similarity1
Modified residuei366N6-acetyllysine; alternateBy similarity1
Modified residuei366N6-succinyllysine; alternateBy similarity1
Modified residuei385N6-acetyllysine; alternateBy similarity1
Modified residuei385N6-succinyllysine; alternateBy similarity1
Modified residuei401N6-acetyllysine; alternateBy similarity1
Modified residuei401N6-succinyllysine; alternateBy similarity1
Modified residuei428N6-acetyllysine; alternateBy similarity1
Modified residuei428N6-succinyllysine; alternateBy similarity1
Modified residuei431N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ66HF8.
PRIDEiQ66HF8.

PTM databases

iPTMnetiQ66HF8.
PhosphoSitePlusiQ66HF8.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015282.

Structurei

3D structure databases

ProteinModelPortaliQ66HF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ66HF8.
KOiK00128.
PhylomeDBiQ66HF8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNARFLVPR LLCLQGRTTS YSTAAALPNP IPNPEIRYNQ LFINNEWHDA
60 70 80 90 100
VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVRAAREAFR LGSPWRRMDA
110 120 130 140 150
SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY
160 170 180 190 200
LAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP
210 220 230 240 250
ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA
260 270 280 290 300
IAQHMDVDKV AFTGSTEVGH LIQKAAGDSN LKRVTLELGG KSPSIVLADA
310 320 330 340 350
DMDHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYHEFLER TVEKAKKRKV
360 370 380 390 400
GNPFELDTQQ GPQVDKEQFE KILGYIRLGQ KEGAKLLCGG ERFGERGFFI
410 420 430 440 450
KPTVFGNVQD DMRIAREEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV
460 470 480 490 500
FTRDLDKALY FSQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG
510
LKAYTEVKTV TIKVSEKNS
Length:519
Mass (Da):57,625
Last modified:October 11, 2004 - v1
Checksum:i6D25E0E806F8EA50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081884 mRNA. Translation: AAH81884.1.
RefSeqiNP_001011975.1. NM_001011975.1.
UniGeneiRn.12547.

Genome annotation databases

GeneIDi298079.
KEGGirno:298079.
UCSCiRGD:1306737. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081884 mRNA. Translation: AAH81884.1.
RefSeqiNP_001011975.1. NM_001011975.1.
UniGeneiRn.12547.

3D structure databases

ProteinModelPortaliQ66HF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015282.

PTM databases

iPTMnetiQ66HF8.
PhosphoSitePlusiQ66HF8.

Proteomic databases

PaxDbiQ66HF8.
PRIDEiQ66HF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi298079.
KEGGirno:298079.
UCSCiRGD:1306737. rat.

Organism-specific databases

CTDi219.
RGDi1306737. Aldh1b1.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ66HF8.
KOiK00128.
PhylomeDBiQ66HF8.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Miscellaneous databases

PROiQ66HF8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1B1_RAT
AccessioniPrimary (citable) accession number: Q66HF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.