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Protein

Transmembrane 9 superfamily member 1

Gene

Tm9sf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in autophagy.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 1
Gene namesi
Name:Tm9sf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307085. Tm9sf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence analysisAdd
BLAST
Transmembranei518 – 53821HelicalSequence analysisAdd
BLAST
Transmembranei552 – 57221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 589562Transmembrane 9 superfamily member 1PRO_0000034364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ66HF2.
PeptideAtlasiQ66HF2.
PRIDEiQ66HF2.

Expressioni

Gene expression databases

GenevisibleiQ66HF2. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4574204.
STRINGi10116.ENSRNOP00000026734.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG108585.
InParanoidiQ66HF2.
KOiK17085.
OMAiWYKSTVI.
OrthoDBiEOG72C4ZW.
PhylomeDBiQ66HF2.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLGHPRSW SCHCLPVLIL LLGIGHGPRV EGVTHYKPGD PVILYVNKVG
60 70 80 90 100
PYHNPQETYH YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN
110 120 130 140 150
VEKRILCHMQ LSSAQVEQLR QAIEELYYFE FVVDDLPIRG FVGYMEESGF
160 170 180 190 200
LPHSHKIGLW THLDFHLEFH GDRIIFANVS VRDVKPHSLD GLRSDELLGL
210 220 230 240 250
THTYSVRWSE TSVEHRSDRR RADDGGFFPR TLEIHWLSII NSMVLVFLLV
260 270 280 290 300
GFVAVILMRV LRNDLARYNL DEETSSGGSS DDFDQGDNGW KIIHTDVFRF
310 320 330 340 350
PPCRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA
360 370 380 390 400
LTCCISGYVS SHFYRQIGGE RWVWNIILTT SLFSVPFFLT WSVVNSVHWA
410 420 430 440 450
NGSTQALPVT TILLLLTVWL LVGFPLTVIG GIFGKNNASP FDAPCRTKNI
460 470 480 490 500
AREIPPQPCA ISVELYYIFA TVWGREQYTL YGILFFVFAI LLSVGACISI
510 520 530 540 550
ALTYFQLSGE DYRWWWRSVL SVGSTGLFIF LYSVFYYARR SNMSGAVQTV
560 570 580
EFFGYSLLTG YVFFLMLGTI SFFSSLKFIR YIYVNLKMD
Length:589
Mass (Da):66,918
Last modified:October 11, 2004 - v1
Checksum:iC429C098C911E3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081891 mRNA. Translation: AAH81891.1.
RefSeqiNP_001012155.1. NM_001012155.1.
UniGeneiRn.12071.

Genome annotation databases

EnsembliENSRNOT00000026734; ENSRNOP00000026734; ENSRNOG00000019710.
GeneIDi361043.
KEGGirno:361043.
UCSCiRGD:1307085. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081891 mRNA. Translation: AAH81891.1.
RefSeqiNP_001012155.1. NM_001012155.1.
UniGeneiRn.12071.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4574204.
STRINGi10116.ENSRNOP00000026734.

Proteomic databases

PaxDbiQ66HF2.
PeptideAtlasiQ66HF2.
PRIDEiQ66HF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026734; ENSRNOP00000026734; ENSRNOG00000019710.
GeneIDi361043.
KEGGirno:361043.
UCSCiRGD:1307085. rat.

Organism-specific databases

CTDi10548.
RGDi1307085. Tm9sf1.

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG108585.
InParanoidiQ66HF2.
KOiK17085.
OMAiWYKSTVI.
OrthoDBiEOG72C4ZW.
PhylomeDBiQ66HF2.

Miscellaneous databases

PROiQ66HF2.

Gene expression databases

GenevisibleiQ66HF2. RN.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiTM9S1_RAT
AccessioniPrimary (citable) accession number: Q66HF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.