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Q66HE7

- CDKL1_RAT

UniProt

Q66HE7 - CDKL1_RAT

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Protein
Cyclin-dependent kinase-like 1
Gene
Cdkl1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei126 – 1261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. heart development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 1 (EC:2.7.11.22)
Gene namesi
Name:Cdkl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1305080. Cdkl1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Cyclin-dependent kinase-like 1
PRO_0000085812Add
BLAST

Proteomic databases

PRIDEiQ66HE7.

Expressioni

Gene expression databases

GenevestigatoriQ66HE7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006374.

Structurei

3D structure databases

ProteinModelPortaliQ66HE7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093115.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ66HE7.
KOiK08824.
OMAiHHPYFEN.
OrthoDBiEOG7992PS.
PhylomeDBiQ66HE7.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HE7-1 [UniParc]FASTAAdd to Basket

« Hide

MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR    50
EIRMLKQLKH PNLVSLLEVF RRKRRLHLVF EYCHHTVLHE LDRYQRGVPE 100
PLVKNITWQT LQAVNFCHKH NCIHRDVKPE NILITKHSVI KLCDFGFARL 150
LTGPGDYYTD YVATRWYRSP ELLVGDTQYG PPVDVWAIGC VFAELLSGVP 200
LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI PDPEDMETLE 250
LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI RDVGELARPH 300
DKPTRKTLRQ SRKHLTGLQH LPQLTSSSVL PALDRKKYHC GTRNFNYHFP 350
NI 352
Length:352
Mass (Da):40,899
Last modified:October 11, 2004 - v1
Checksum:iDB9CDF5464E66E24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081896 mRNA. Translation: AAH81896.1.
RefSeqiNP_001020292.1. NM_001025121.1.
XP_006240233.1. XM_006240171.1.
XP_006240234.1. XM_006240172.1.
UniGeneiRn.182073.

Genome annotation databases

EnsembliENSRNOT00000006374; ENSRNOP00000006374; ENSRNOG00000038720.
GeneIDi314198.
KEGGirno:314198.
UCSCiRGD:1305080. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081896 mRNA. Translation: AAH81896.1 .
RefSeqi NP_001020292.1. NM_001025121.1.
XP_006240233.1. XM_006240171.1.
XP_006240234.1. XM_006240172.1.
UniGenei Rn.182073.

3D structure databases

ProteinModelPortali Q66HE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006374.

Proteomic databases

PRIDEi Q66HE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006374 ; ENSRNOP00000006374 ; ENSRNOG00000038720 .
GeneIDi 314198.
KEGGi rno:314198.
UCSCi RGD:1305080. rat.

Organism-specific databases

CTDi 8814.
RGDi 1305080. Cdkl1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00650000093115.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q66HE7.
KOi K08824.
OMAi HHPYFEN.
OrthoDBi EOG7992PS.
PhylomeDBi Q66HE7.
TreeFami TF101031.

Miscellaneous databases

NextBioi 667281.
PROi Q66HE7.

Gene expression databases

Genevestigatori Q66HE7.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCDKL1_RAT
AccessioniPrimary (citable) accession number: Q66HE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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