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Q66HE7 (CDKL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 1

EC=2.7.11.22
Gene names
Name:Cdkl1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Cyclin-dependent kinase-like 1
PRO_0000085812

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66HE7 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: DB9CDF5464E66E24

FASTA35240,899
        10         20         30         40         50         60 
MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR EIRMLKQLKH 

        70         80         90        100        110        120 
PNLVSLLEVF RRKRRLHLVF EYCHHTVLHE LDRYQRGVPE PLVKNITWQT LQAVNFCHKH 

       130        140        150        160        170        180 
NCIHRDVKPE NILITKHSVI KLCDFGFARL LTGPGDYYTD YVATRWYRSP ELLVGDTQYG 

       190        200        210        220        230        240 
PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI 

       250        260        270        280        290        300 
PDPEDMETLE LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI RDVGELARPH 

       310        320        330        340        350 
DKPTRKTLRQ SRKHLTGLQH LPQLTSSSVL PALDRKKYHC GTRNFNYHFP NI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081896 mRNA. Translation: AAH81896.1.
RefSeqNP_001020292.1. NM_001025121.1.
XP_006240233.1. XM_006240171.1.
XP_006240234.1. XM_006240172.1.
UniGeneRn.182073.

3D structure databases

ProteinModelPortalQ66HE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006374.

Proteomic databases

PRIDEQ66HE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006374; ENSRNOP00000006374; ENSRNOG00000038720.
GeneID314198.
KEGGrno:314198.
UCSCRGD:1305080. rat.

Organism-specific databases

CTD8814.
RGD1305080. Cdkl1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00650000093115.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ66HE7.
KOK08824.
OMAHHPYFEN.
OrthoDBEOG7992PS.
PhylomeDBQ66HE7.
TreeFamTF101031.

Gene expression databases

GenevestigatorQ66HE7.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio667281.
PROQ66HE7.

Entry information

Entry nameCDKL1_RAT
AccessionPrimary (citable) accession number: Q66HE7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families