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Protein

Kelch-like protein 36

Gene

Klhl36

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 36
Gene namesi
Name:Klhl36
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1561366. Klhl36.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746931 – 613Kelch-like protein 36Add BLAST613

Proteomic databases

PaxDbiQ66HD2.

PTM databases

iPTMnetiQ66HD2.
PhosphoSitePlusiQ66HD2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016422.
GenevisibleiQ66HD2. RN.

Interactioni

Subunit structurei

Interacts with CUL3.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ66HD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 112BTBPROSITE-ProRule annotationAdd BLAST68
Domaini147 – 249BACKAdd BLAST103
Repeati294 – 343Kelch 1Add BLAST50
Repeati344 – 395Kelch 2Add BLAST52
Repeati396 – 442Kelch 3Add BLAST47
Repeati444 – 491Kelch 4Add BLAST48
Repeati492 – 544Kelch 5Add BLAST53
Repeati545 – 593Kelch 6Add BLAST49

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ66HD2.
KOiK13958.
OMAiAVDFCCE.
PhylomeDBiQ66HD2.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF246. PTHR24412:SF246. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASKQMRVS RPYKISESSK VYHWPGHSTT VLQRLNEQRL HGLFCDVVLV
60 70 80 90 100
VEEQQVPAHR NLLAVCSDYF NSMFTLGMRE AFQKEVELVG TSYVGLKAVV
110 120 130 140 150
DFLYSSELEL DGSNIDYILE TAHLLQIWTV VDFCCEYLEQ EVSEDNYLYL
160 170 180 190 200
QELASIYSLK RLDAFIDSFV LNHFSTLSFT PDFLQTVSVQ KLCIYLSSGQ
210 220 230 240 250
VQHTWEYDLL QAALQWLTQQ PEREVHTCRV LENIRFPLFP EDILLQRVKL
260 270 280 290 300
AMCSLLPSEA NGEGFVEEAM HYHNSLVAQP VLQTKRTLLR SEECLLFVGG
310 320 330 340 350
EVSERCLELS DDTCYLDTKN EQWVKETSLP ARRSHHCVAV LGGFIFVAGG
360 370 380 390 400
SFSRDNGGNA ASNLLYRYDP RRKQWIKVAS MNQRRVDFYL ASIEDMLVAV
410 420 430 440 450
GGRNENGALS SVETYSPKTN SWTYVAGLPR FTYGHAGTIY KDFVYISGGH
460 470 480 490 500
DYQIGPYRKN LLCYDHRTDV WEERRPMTTA RGWHSMCSLG DSIYSIGGSD
510 520 530 540 550
DHMESMERFD VLGVEAYSPQ CNQWTRVAPL LQANSESGVA VWQGRIYILG
560 570 580 590 600
GYSWESTAFS RAVQVYDREA NRWSRGPDLP NAIAGVSACV CALNPRLEEK
610
KKKNKDKRQD RGQ
Length:613
Mass (Da):69,935
Last modified:October 11, 2004 - v1
Checksum:i3C57095D11BD4328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081914 mRNA. Translation: AAH81914.1.
RefSeqiNP_001017511.1. NM_001017511.1.
XP_006255780.1. XM_006255718.2.
UniGeneiRn.139361.

Genome annotation databases

EnsembliENSRNOT00000022091; ENSRNOP00000022091; ENSRNOG00000016422.
ENSRNOT00000081019; ENSRNOP00000068927; ENSRNOG00000016422.
GeneIDi498957.
KEGGirno:498957.
UCSCiRGD:1561366. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081914 mRNA. Translation: AAH81914.1.
RefSeqiNP_001017511.1. NM_001017511.1.
XP_006255780.1. XM_006255718.2.
UniGeneiRn.139361.

3D structure databases

ProteinModelPortaliQ66HD2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ66HD2.
PhosphoSitePlusiQ66HD2.

Proteomic databases

PaxDbiQ66HD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022091; ENSRNOP00000022091; ENSRNOG00000016422.
ENSRNOT00000081019; ENSRNOP00000068927; ENSRNOG00000016422.
GeneIDi498957.
KEGGirno:498957.
UCSCiRGD:1561366. rat.

Organism-specific databases

CTDi79786.
RGDi1561366. Klhl36.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ66HD2.
KOiK13958.
OMAiAVDFCCE.
PhylomeDBiQ66HD2.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ66HD2.

Gene expression databases

BgeeiENSRNOG00000016422.
GenevisibleiQ66HD2. RN.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030585. KLHL36.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF246. PTHR24412:SF246. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH36_RAT
AccessioniPrimary (citable) accession number: Q66HD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.