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Protein

Dynein intermediate chain 2, axonemal

Gene

Dnai2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 2, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 2
Gene namesi
Name:Dnai2
Synonyms:Dnaic2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359602. Dnai2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Dynein intermediate chain 2, axonemalPRO_0000365817Add
BLAST

Proteomic databases

PaxDbiQ66HC9.
PRIDEiQ66HC9.

PTM databases

iPTMnetiQ66HC9.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (By similarity). Interacts with PIH1D3 (By similarity). Interacts with HEATR2; probably involved in outer arm dynein assembly (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033498.

Structurei

3D structure databases

ProteinModelPortaliQ66HC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati214 – 25441WD 1Add
BLAST
Repeati261 – 30242WD 2Add
BLAST
Repeati362 – 40140WD 3Add
BLAST
Repeati405 – 44541WD 4Add
BLAST
Repeati450 – 48940WD 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi501 – 615115Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU37. Eukaryota.
ENOG410XTD6. LUCA.
GeneTreeiENSGT00840000129862.
HOGENOMiHOG000259651.
HOVERGENiHBG013035.
InParanoidiQ66HC9.
KOiK11143.
OMAiETRGINH.
OrthoDBiEOG70GMF5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVYVYVKK RSEFGKQCNF SDRQAELNID ISPNPELAAL YVERNPVDTG
60 70 80 90 100
IQCSASMSEH EANTERFEME NCGVNHVEGG WPKDVNPQEL EQTIRFRKKV
110 120 130 140 150
EKDENYINAV MQLGSIMEHC IKQNNAIDIY EEYFDDEEAV EVTEEAPSAK
160 170 180 190 200
TINVFRDPQE IKRTATHLSW HPDGNKKLAV AYSCLQFQRS PMGMSHDSYI
210 220 230 240 250
WDLENPNRPE IALKPSSPLI TLEYNPKDSH VLLGGCYNGQ IACWDTRKGS
260 270 280 290 300
LVAELSTIEF SHRDPVYGTI WLQSKTGTEC FSASTDGQVM WWDIRKISEP
310 320 330 340 350
TEVVIMDITR KEQLENALGA ISLEFESTLP TKFMVGTEQG IVISCNRKAK
360 370 380 390 400
TPAEKIVCTF SGHHGPIYAL QRNPFYPKNF LTVGDWAARI WSEESRESSI
410 420 430 440 450
MWTRYHMAYL SDGAWSPVRP AVFFTTKMDG TLDIWDLVFK QCDPALSLKV
460 470 480 490 500
CDDPLFCLRV QDTGCLIACG SELGTTTLLE VSSSLSTLQR NERNIASSIF
510 520 530 540 550
ERETRREKIL EARHREMRLK EKGKAEGRDD DQKEEETALD LDELVNKAEE
560 570 580 590 600
EFFEVIFAEL KRKEAEALKK KPKPKKASIE VEGEDELEDI AGEEEESGII
610
MGEDTGEDDM DEKNEGGAP
Length:619
Mass (Da):70,318
Last modified:October 11, 2004 - v1
Checksum:i8AC0A2156F8BD8A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081920 mRNA. Translation: AAH81920.1.
RefSeqiNP_001007727.1. NM_001007726.1.
UniGeneiRn.137787.

Genome annotation databases

EnsembliENSRNOT00000038852; ENSRNOP00000033498; ENSRNOG00000024523.
GeneIDi360654.
KEGGirno:360654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081920 mRNA. Translation: AAH81920.1.
RefSeqiNP_001007727.1. NM_001007726.1.
UniGeneiRn.137787.

3D structure databases

ProteinModelPortaliQ66HC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033498.

PTM databases

iPTMnetiQ66HC9.

Proteomic databases

PaxDbiQ66HC9.
PRIDEiQ66HC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038852; ENSRNOP00000033498; ENSRNOG00000024523.
GeneIDi360654.
KEGGirno:360654.

Organism-specific databases

CTDi64446.
RGDi1359602. Dnai2.

Phylogenomic databases

eggNOGiENOG410IU37. Eukaryota.
ENOG410XTD6. LUCA.
GeneTreeiENSGT00840000129862.
HOGENOMiHOG000259651.
HOVERGENiHBG013035.
InParanoidiQ66HC9.
KOiK11143.
OMAiETRGINH.
OrthoDBiEOG70GMF5.

Miscellaneous databases

PROiQ66HC9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDNAI2_RAT
AccessioniPrimary (citable) accession number: Q66HC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.