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Protein

Nuclear pore complex protein Nup93

Gene

Nup93

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859 snRNP Assembly
R-RNO-3108214 SUMOylation of DNA damage response and repair proteins
R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-4551638 SUMOylation of chromatin organization proteins
R-RNO-4615885 SUMOylation of DNA replication proteins
R-RNO-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
Nucleoporin Nup93
Gene namesi
Name:Nup93
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1311525 Nup93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562961 – 819Nuclear pore complex protein Nup93Add BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphothreonineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HC5
PRIDEiQ66HC5

PTM databases

iPTMnetiQ66HC5
PhosphoSitePlusiQ66HC5

Expressioni

Gene expression databases

BgeeiENSRNOG00000018564
GenevisibleiQ66HC5 RN

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct. Does not interact with TPR. Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling.By similarity

Protein-protein interaction databases

BioGridi253671, 3 interactors
CORUMiQ66HC5
STRINGi10116.ENSRNOP00000025086

Structurei

3D structure databases

ProteinModelPortaliQ66HC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2168 Eukaryota
ENOG410XPN3 LUCA
GeneTreeiENSGT00390000016353
HOGENOMiHOG000007350
HOVERGENiHBG052701
InParanoidiQ66HC5
KOiK14309
OMAiIAFLFRM
OrthoDBiEOG091G02T1
PhylomeDBiQ66HC5

Family and domain databases

InterProiView protein in InterPro
IPR007231 Nucleoporin_int_Nup93/Nic96
PANTHERiPTHR11225 PTHR11225, 1 hit
PfamiView protein in Pfam
PF04097 Nic96, 1 hit

Sequencei

Sequence statusi: Complete.

Q66HC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR
60 70 80 90 100
TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA
160 170 180 190 200
SGEDALDFTQ ESEPSYVSDV SPPGRSSLDS IEMAYARQIY IYNEKIVSGH
210 220 230 240 250
LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV
260 270 280 290 300
RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
310 320 330 340 350
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT
360 370 380 390 400
WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT
410 420 430 440 450
DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE
460 470 480 490 500
SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK
510 520 530 540 550
LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY
560 570 580 590 600
FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
610 620 630 640 650
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV
660 670 680 690 700
PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD
710 720 730 740 750
EYHSGHIDRA FDIIDRLKLV PLNQESMEER VAAFRNFSDE IRHNLSEVLL
760 770 780 790 800
ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP
810
YRTSGDTNAR LVQMEVLMN
Length:819
Mass (Da):93,302
Last modified:October 11, 2004 - v1
Checksum:iF49DE268CA25B863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081925 mRNA Translation: AAH81925.1
RefSeqiNP_001011925.1, NM_001011925.1
UniGeneiRn.137413

Genome annotation databases

EnsembliENSRNOT00000025086; ENSRNOP00000025086; ENSRNOG00000018564
GeneIDi291874
KEGGirno:291874
UCSCiRGD:1311525 rat

Similar proteinsi

Entry informationi

Entry nameiNUP93_RAT
AccessioniPrimary (citable) accession number: Q66HC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health