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Protein

Nuclear pore complex protein Nup93

Gene

Nup93

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
Nucleoporin Nup93
Gene namesi
Name:Nup93
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1311525. Nup93.

Subcellular locationi

  • Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Nucleusnuclear pore complex By similarity
  • Nucleus envelope By similarity

  • Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.By similarity

GO - Cellular componenti

  • nuclear envelope Source: UniProtKB
  • nuclear membrane Source: UniProtKB
  • nuclear periphery Source: UniProtKB
  • nuclear pore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562961 – 819Nuclear pore complex protein Nup93Add BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphothreonineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HC5.
PRIDEiQ66HC5.

PTM databases

iPTMnetiQ66HC5.
PhosphoSitePlusiQ66HC5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018564.
GenevisibleiQ66HC5. RN.

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR. Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling.By similarity

Protein-protein interaction databases

BioGridi253671. 3 interactors.
STRINGi10116.ENSRNOP00000025086.

Structurei

3D structure databases

ProteinModelPortaliQ66HC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2168. Eukaryota.
ENOG410XPN3. LUCA.
GeneTreeiENSGT00390000016353.
HOGENOMiHOG000007350.
HOVERGENiHBG052701.
InParanoidiQ66HC5.
KOiK14309.
OMAiTERLRCH.
OrthoDBiEOG091G02T1.
PhylomeDBiQ66HC5.

Family and domain databases

InterProiIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
PANTHERiPTHR11225. PTHR11225. 1 hit.
PfamiPF04097. Nic96. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR
60 70 80 90 100
TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA
160 170 180 190 200
SGEDALDFTQ ESEPSYVSDV SPPGRSSLDS IEMAYARQIY IYNEKIVSGH
210 220 230 240 250
LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV
260 270 280 290 300
RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
310 320 330 340 350
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT
360 370 380 390 400
WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT
410 420 430 440 450
DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE
460 470 480 490 500
SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK
510 520 530 540 550
LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY
560 570 580 590 600
FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
610 620 630 640 650
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV
660 670 680 690 700
PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD
710 720 730 740 750
EYHSGHIDRA FDIIDRLKLV PLNQESMEER VAAFRNFSDE IRHNLSEVLL
760 770 780 790 800
ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP
810
YRTSGDTNAR LVQMEVLMN
Length:819
Mass (Da):93,302
Last modified:October 11, 2004 - v1
Checksum:iF49DE268CA25B863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081925 mRNA. Translation: AAH81925.1.
RefSeqiNP_001011925.1. NM_001011925.1.
UniGeneiRn.137413.

Genome annotation databases

EnsembliENSRNOT00000025086; ENSRNOP00000025086; ENSRNOG00000018564.
GeneIDi291874.
KEGGirno:291874.
UCSCiRGD:1311525. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081925 mRNA. Translation: AAH81925.1.
RefSeqiNP_001011925.1. NM_001011925.1.
UniGeneiRn.137413.

3D structure databases

ProteinModelPortaliQ66HC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253671. 3 interactors.
STRINGi10116.ENSRNOP00000025086.

PTM databases

iPTMnetiQ66HC5.
PhosphoSitePlusiQ66HC5.

Proteomic databases

PaxDbiQ66HC5.
PRIDEiQ66HC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025086; ENSRNOP00000025086; ENSRNOG00000018564.
GeneIDi291874.
KEGGirno:291874.
UCSCiRGD:1311525. rat.

Organism-specific databases

CTDi9688.
RGDi1311525. Nup93.

Phylogenomic databases

eggNOGiKOG2168. Eukaryota.
ENOG410XPN3. LUCA.
GeneTreeiENSGT00390000016353.
HOGENOMiHOG000007350.
HOVERGENiHBG052701.
InParanoidiQ66HC5.
KOiK14309.
OMAiTERLRCH.
OrthoDBiEOG091G02T1.
PhylomeDBiQ66HC5.

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ66HC5.

Gene expression databases

BgeeiENSRNOG00000018564.
GenevisibleiQ66HC5. RN.

Family and domain databases

InterProiIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
PANTHERiPTHR11225. PTHR11225. 1 hit.
PfamiPF04097. Nic96. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP93_RAT
AccessioniPrimary (citable) accession number: Q66HC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.