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Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Wdr56
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1312006. Ift80.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510441 – 777Intraflagellar transport protein 80 homologAdd BLAST777

Proteomic databases

PaxDbiQ66HB3.
PRIDEiQ66HB3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009808.
GenevisibleiQ66HB3. RN.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013216.

Structurei

3D structure databases

ProteinModelPortaliQ66HB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 50WD 1Add BLAST39
Repeati104 – 143WD 2Add BLAST40
Repeati145 – 185WD 3Add BLAST41
Repeati186 – 225WD 4Add BLAST40
Repeati227 – 265WD 5Add BLAST39
Repeati267 – 306WD 6Add BLAST40
Repeati504 – 542WD 7Add BLAST39

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1524. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ66HB3.
KOiK19678.
OMAiWRAHDGL.
OrthoDBiEOG091G03FC.
PhylomeDBiQ66HB3.
TreeFamiTF106117.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI
60 70 80 90 100
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK
110 120 130 140 150
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGIPV
160 170 180 190 200
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN
210 220 230 240 250
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH
260 270 280 290 300
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
310 320 330 340 350
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS
360 370 380 390 400
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE
410 420 430 440 450
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP
460 470 480 490 500
LGDGKLLSHK NEISEVALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE
510 520 530 540 550
QIIKLGTMVH TLAWCDTCNI LCGLQDTRFT VWYYPNAVYV DRDILPKTLY
560 570 580 590 600
ERDASEYSKN PHIVSFVGNQ VTVRRADGSL VHISISPYPA ILHEYVSSSK
610 620 630 640 650
WEDAVRLCRF VKEQSLWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN
660 670 680 690 700
AMKDLPSRES KMAHILMFSG NIQEAETILL QAGLVYQAIQ ININLYNWER
710 720 730 740 750
ALELAVKYKT HVDTVLAYRQ KFLETFGKQE TNKRYLQYAE GLQIDWEKIK
760 770
AKIEMEITKE RDRSSSGQSS KNTGLKP
Length:777
Mass (Da):87,780
Last modified:October 11, 2004 - v1
Checksum:i4D1C68CDC8C600EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081931 mRNA. Translation: AAH81931.1.
BC081937 mRNA. Translation: AAH81937.1.
RefSeqiNP_001013933.1. NM_001013911.1.
UniGeneiRn.6742.

Genome annotation databases

EnsembliENSRNOT00000013216; ENSRNOP00000013216; ENSRNOG00000009808.
ENSRNOT00000091140; ENSRNOP00000069823; ENSRNOG00000009808.
GeneIDi295106.
KEGGirno:295106.
UCSCiRGD:1312006. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081931 mRNA. Translation: AAH81931.1.
BC081937 mRNA. Translation: AAH81937.1.
RefSeqiNP_001013933.1. NM_001013911.1.
UniGeneiRn.6742.

3D structure databases

ProteinModelPortaliQ66HB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013216.

Proteomic databases

PaxDbiQ66HB3.
PRIDEiQ66HB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013216; ENSRNOP00000013216; ENSRNOG00000009808.
ENSRNOT00000091140; ENSRNOP00000069823; ENSRNOG00000009808.
GeneIDi295106.
KEGGirno:295106.
UCSCiRGD:1312006. rat.

Organism-specific databases

CTDi57560.
RGDi1312006. Ift80.

Phylogenomic databases

eggNOGiKOG1524. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ66HB3.
KOiK19678.
OMAiWRAHDGL.
OrthoDBiEOG091G03FC.
PhylomeDBiQ66HB3.
TreeFamiTF106117.

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ66HB3.

Gene expression databases

BgeeiENSRNOG00000009808.
GenevisibleiQ66HB3. RN.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFT80_RAT
AccessioniPrimary (citable) accession number: Q66HB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.