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Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Wdr56
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1312006 Ift80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510441 – 777Intraflagellar transport protein 80 homologAdd BLAST777

Proteomic databases

PaxDbiQ66HB3
PRIDEiQ66HB3

Expressioni

Gene expression databases

BgeeiENSRNOG00000009808
GenevisibleiQ66HB3 RN

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013216

Structurei

3D structure databases

ProteinModelPortaliQ66HB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 50WD 1Add BLAST39
Repeati104 – 143WD 2Add BLAST40
Repeati145 – 185WD 3Add BLAST41
Repeati186 – 225WD 4Add BLAST40
Repeati227 – 265WD 5Add BLAST39
Repeati267 – 306WD 6Add BLAST40
Repeati504 – 542WD 7Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1524 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00440000033499
HOGENOMiHOG000256816
HOVERGENiHBG056828
InParanoidiQ66HB3
KOiK19678
OMAiIRWRAHD
OrthoDBiEOG091G03FC
PhylomeDBiQ66HB3
TreeFamiTF106117

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q66HB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI
60 70 80 90 100
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK
110 120 130 140 150
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGIPV
160 170 180 190 200
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN
210 220 230 240 250
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH
260 270 280 290 300
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
310 320 330 340 350
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS
360 370 380 390 400
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE
410 420 430 440 450
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP
460 470 480 490 500
LGDGKLLSHK NEISEVALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE
510 520 530 540 550
QIIKLGTMVH TLAWCDTCNI LCGLQDTRFT VWYYPNAVYV DRDILPKTLY
560 570 580 590 600
ERDASEYSKN PHIVSFVGNQ VTVRRADGSL VHISISPYPA ILHEYVSSSK
610 620 630 640 650
WEDAVRLCRF VKEQSLWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN
660 670 680 690 700
AMKDLPSRES KMAHILMFSG NIQEAETILL QAGLVYQAIQ ININLYNWER
710 720 730 740 750
ALELAVKYKT HVDTVLAYRQ KFLETFGKQE TNKRYLQYAE GLQIDWEKIK
760 770
AKIEMEITKE RDRSSSGQSS KNTGLKP
Length:777
Mass (Da):87,780
Last modified:October 11, 2004 - v1
Checksum:i4D1C68CDC8C600EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081931 mRNA Translation: AAH81931.1
BC081937 mRNA Translation: AAH81937.1
RefSeqiNP_001013933.1, NM_001013911.1
UniGeneiRn.6742

Genome annotation databases

EnsembliENSRNOT00000013216; ENSRNOP00000013216; ENSRNOG00000009808
ENSRNOT00000091140; ENSRNOP00000069823; ENSRNOG00000009808
GeneIDi295106
KEGGirno:295106
UCSCiRGD:1312006 rat

Similar proteinsi

Entry informationi

Entry nameiIFT80_RAT
AccessioniPrimary (citable) accession number: Q66HB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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