Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein 105 kDa

Gene

Hsph1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 105 kDa
Alternative name(s):
Heat shock 110 kDa protein
Gene namesi
Name:Hsph1
Synonyms:Hsp105, Hsp110
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311609. Hsph1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 858857Heat shock protein 105 kDaPRO_0000235976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei471 – 4711N6-acetyllysineBy similarity
Modified residuei509 – 5091PhosphoserineBy similarity
Modified residuei510 – 5101PhosphoserineBy similarity
Modified residuei558 – 5581PhosphoserineCombined sources
Modified residuei562 – 5621PhosphothreonineBy similarity
Modified residuei810 – 8101PhosphoserineCombined sources
Modified residuei816 – 8161PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ66HA8.
PRIDEiQ66HA8.

PTM databases

iPTMnetiQ66HA8.
PhosphoSiteiQ66HA8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000902.
GenevisibleiQ66HA8. RN.

Interactioni

Subunit structurei

Interacts with HSPA8/HSC70.By similarity

Protein-protein interaction databases

BioGridi252555. 1 interaction.
STRINGi10116.ENSRNOP00000001201.

Structurei

3D structure databases

ProteinModelPortaliQ66HA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiQ66HA8.
KOiK09485.
OMAiVVRTHEI.
OrthoDBiEOG091G04Y6.
PhylomeDBiQ66HA8.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGLDVGS QSCYIAVARA GGIETIANEF SDRCTPSVIS FGPKNRTIGV
60 70 80 90 100
AAKNQQITHA NNTVSSFKRF HGRAFNDPFI QKEKENLSYD LVPMKNGGVG
110 120 130 140 150
IKVMYMDEDH LFSVEQITAM LLTKLKETAE NNLKKPVTDC VISVPSFFTD
160 170 180 190 200
AERRSVLDAA QIVGLNCLRL MNDMTAVALN YGIYKQDLPN ADEKPRVVVF
210 220 230 240 250
VDMGHSSFQV SACAFNKGKL KVLGTAFDPF LGGKNFDEKL VEHFCAEFKT
260 270 280 290 300
KYKLDAKSKI RALLRLHQEC EKLKKLMSSN STDLPLNIEC FMNDKDVSAK
310 320 330 340 350
MNRSQFEELC AELLQKIEVP LHLLMEQTHL KTEEVSAIEI VGGATRIPAV
360 370 380 390 400
KERIARFFGK DVSTTLNADE AVARGCALQC AILSPAFKVR EFSVTDAVPF
410 420 430 440 450
PISLVWNHDS EETEGVHEVF SRNHAAPFSK VLTFLRRGPF ELEAFYSDPQ
460 470 480 490 500
AVPYPEAKIG RFVVQNVSAQ KDGEKSKVKV KVRVNTHGIF TISTASMVEK
510 520 530 540 550
VPTEEEDGSS VEADMECPNQ KPAESSDVDK NIQQDNSEAG TQPQVQTDGQ
560 570 580 590 600
QTSQSPPSPE LTSEENKIPD ADKANEKKVD QPPEAKKPKI KVVNVELPVE
610 620 630 640 650
ANLVWQLGRD LLNMYIETEG KMIMQDKLEK ERNDAKNAVE ECVYEFRDKL
660 670 680 690 700
CGPYEKFICE QEHEKFLRLL TETEDWLYEE GEDQAKQAYI DKLEELMKMG
710 720 730 740 750
TPVKVRFQEA EERPRVLEEL GQRLQHYAKI AADFRGKDEK YNHIDESEMK
760 770 780 790 800
KVEKSVNEVM EWMNNVMNAQ AKRSLHQDPV VRTHEISAKV KELNNVCEPV
810 820 830 840 850
VTQPKPKIES PKLERTPNGP NMDKKEDLEG KSNLGADAPH QNGECHPNEK

GSVSMDLD
Length:858
Mass (Da):96,419
Last modified:October 11, 2004 - v1
Checksum:i0AF62115FF795C66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081945 mRNA. Translation: AAH81945.1.
RefSeqiNP_001011901.1. NM_001011901.1.
UniGeneiRn.37805.

Genome annotation databases

EnsembliENSRNOT00000001201; ENSRNOP00000001201; ENSRNOG00000000902.
GeneIDi288444.
KEGGirno:288444.
UCSCiRGD:1311609. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081945 mRNA. Translation: AAH81945.1.
RefSeqiNP_001011901.1. NM_001011901.1.
UniGeneiRn.37805.

3D structure databases

ProteinModelPortaliQ66HA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252555. 1 interaction.
STRINGi10116.ENSRNOP00000001201.

PTM databases

iPTMnetiQ66HA8.
PhosphoSiteiQ66HA8.

Proteomic databases

PaxDbiQ66HA8.
PRIDEiQ66HA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001201; ENSRNOP00000001201; ENSRNOG00000000902.
GeneIDi288444.
KEGGirno:288444.
UCSCiRGD:1311609. rat.

Organism-specific databases

CTDi10808.
RGDi1311609. Hsph1.

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOGENOMiHOG000228138.
HOVERGENiHBG047955.
InParanoidiQ66HA8.
KOiK09485.
OMAiVVRTHEI.
OrthoDBiEOG091G04Y6.
PhylomeDBiQ66HA8.

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiQ66HA8.

Gene expression databases

BgeeiENSRNOG00000000902.
GenevisibleiQ66HA8. RN.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 2 hits.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS105_RAT
AccessioniPrimary (citable) accession number: Q66HA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.