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Protein

ADP-ribosylation factor-like protein 8B

Gene

Arl8b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 357GTPBy similarity
Nucleotide bindingi71 – 755GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8B
Gene namesi
Name:Arl8b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1562830. Arl8b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei1 – 1919Note=Mediates targeting to membranesBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186ADP-ribosylation factor-like protein 8BPRO_0000232925Add
BLAST

Proteomic databases

PaxDbiQ66HA6.
PRIDEiQ66HA6.

PTM databases

iPTMnetiQ66HA6.
PhosphoSiteiQ66HA6.

Expressioni

Gene expression databases

GenevisibleiQ66HA6. RN.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

Protein-protein interaction databases

BioGridi271590. 1 interaction.
STRINGi10116.ENSRNOP00000010053.

Structurei

3D structure databases

ProteinModelPortaliQ66HA6.
SMRiQ66HA6. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ66HA6.
KOiK07955.
OMAiIAHSKSQ.
OrthoDBiEOG7F24V2.
PhylomeDBiQ66HA6.
TreeFamiTF105470.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66HA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI
60 70 80 90 100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD
110 120 130 140 150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,539
Last modified:October 11, 2004 - v1
Checksum:i5030B01AFD749223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081947 mRNA. Translation: AAH81947.1.
RefSeqiNP_001019503.1. NM_001024332.1.
UniGeneiRn.6283.

Genome annotation databases

EnsembliENSRNOT00000080663; ENSRNOP00000071470; ENSRNOG00000055860.
GeneIDi500282.
KEGGirno:500282.
UCSCiRGD:1562830. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081947 mRNA. Translation: AAH81947.1.
RefSeqiNP_001019503.1. NM_001024332.1.
UniGeneiRn.6283.

3D structure databases

ProteinModelPortaliQ66HA6.
SMRiQ66HA6. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi271590. 1 interaction.
STRINGi10116.ENSRNOP00000010053.

PTM databases

iPTMnetiQ66HA6.
PhosphoSiteiQ66HA6.

Proteomic databases

PaxDbiQ66HA6.
PRIDEiQ66HA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080663; ENSRNOP00000071470; ENSRNOG00000055860.
GeneIDi500282.
KEGGirno:500282.
UCSCiRGD:1562830. rat.

Organism-specific databases

CTDi55207.
RGDi1562830. Arl8b.

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ66HA6.
KOiK07955.
OMAiIAHSKSQ.
OrthoDBiEOG7F24V2.
PhylomeDBiQ66HA6.
TreeFamiTF105470.

Miscellaneous databases

PROiQ66HA6.

Gene expression databases

GenevisibleiQ66HA6. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Lung.

Entry informationi

Entry nameiARL8B_RAT
AccessioniPrimary (citable) accession number: Q66HA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.