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Protein

ADP-ribosylation factor-like protein 8B

Gene

Arl8b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lysosome motility. May play a role in chromosome segregation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35GTPBy similarity7
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8B
Gene namesi
Name:Arl8b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1562830. Arl8b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei1 – 19Note=Mediates targeting to membranesBy similarityAdd BLAST19

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329251 – 186ADP-ribosylation factor-like protein 8BAdd BLAST186

Proteomic databases

PaxDbiQ66HA6.
PRIDEiQ66HA6.

PTM databases

iPTMnetiQ66HA6.
PhosphoSitePlusiQ66HA6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000055860.
GenevisibleiQ66HA6. RN.

Interactioni

Subunit structurei

Interacts with tubulin. Interacts with BORCS5; recruits ARL8B to lysosomes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi271590. 1 interactor.
STRINGi10116.ENSRNOP00000010053.

Structurei

3D structure databases

ProteinModelPortaliQ66HA6.
SMRiQ66HA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00890000139352.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ66HA6.
KOiK07955.
OMAiSCYSCSM.
OrthoDBiEOG091G0USZ.
PhylomeDBiQ66HA6.
TreeFamiTF105470.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66HA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI
60 70 80 90 100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD
110 120 130 140 150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,539
Last modified:October 11, 2004 - v1
Checksum:i5030B01AFD749223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081947 mRNA. Translation: AAH81947.1.
RefSeqiNP_001019503.1. NM_001024332.1.
UniGeneiRn.6283.

Genome annotation databases

EnsembliENSRNOT00000080663; ENSRNOP00000071470; ENSRNOG00000055860.
GeneIDi500282.
KEGGirno:500282.
UCSCiRGD:1562830. rat.

Similar proteinsi

Entry informationi

Entry nameiARL8B_RAT
AccessioniPrimary (citable) accession number: Q66HA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 11, 2004
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families