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Protein

Coiled-coil and C2 domain-containing protein 1A

Gene

Cc2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil and C2 domain-containing protein 1A
Alternative name(s):
Five prime repressor element under dual repression-binding protein 1
Short name:
FRE under dual repression-binding protein 1
Short name:
Freud-1
Gene namesi
Name:Cc2d1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306108 Cc2d1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002396111 – 941Coiled-coil and C2 domain-containing protein 1AAdd BLAST941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineCombined sources1
Modified residuei247PhosphoserineBy similarity1
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HA5
PRIDEiQ66HA5

PTM databases

iPTMnetiQ66HA5
PhosphoSitePlusiQ66HA5

Expressioni

Tissue specificityi

Strongly expressed in several brain areas including frontal cortex, cortex, mesencephalon, hippocampus, midbrain and hypothalamus. Also expressed in testis and at low levels in pituitary, liver and kidney. In brain the highest levels are detected in hippocampal pyramidal cells and raphe nuclei.1 Publication

Gene expression databases

BgeeiENSRNOG00000006747
GenevisibleiQ66HA5 RN

Interactioni

Protein-protein interaction databases

IntActiQ66HA5, 1 interactor
STRINGi10116.ENSRNOP00000009806

Structurei

3D structure databases

ProteinModelPortaliQ66HA5
SMRiQ66HA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini633 – 746C2Add BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 384Sequence analysisAdd BLAST47
Coiled coili475 – 508Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 337Pro-richAdd BLAST34

Domaini

The C2 domain is required for the repression.By similarity

Sequence similaritiesi

Belongs to the CC2D1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3837 Eukaryota
ENOG410XPM7 LUCA
GeneTreeiENSGT00390000009595
HOGENOMiHOG000285993
HOVERGENiHBG100866
InParanoidiQ66HA5
KOiK18260
OMAiIYSRGGF
OrthoDBiEOG091G02GK
PhylomeDBiQ66HA5

Family and domain databases

CDDicd08690 C2_Freud-1, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037772 C2_Freud
IPR006608 DM14
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00685 DM14, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66HA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKRNGPQAP PGRGAVTARQ LGLLVDFSPD GLMIPEDGVN DEELEAEFLA
60 70 80 90 100
LVGGQPQALE KLKGKGPLPM EAIEKMARLC MRDLDEDEEG TDEDVEADED
110 120 130 140 150
LLAELNEVLG EERKAVEPAM PVVQPKPSSP NPGIEATLQE RLILYQSAVE
160 170 180 190 200
SARQAGDSAK MRRYDRGLKT LENLLVSAKK GNTINEADIP PPVASGKGPA
210 220 230 240 250
IGHSHTHTTS HLAPVSPPAP EPSVTLEAPS TTAQTSAKPQ LSPDPCSPLA
260 270 280 290 300
RLQSLQHEYK VAALRAKHQD DTATAARYLR VSKSFDPVLE ALSRGELVDL
310 320 330 340 350
SRLPPPPDQL SPEPPLPAAQ PVTPASTLTR PEVPQPPKNL LEALEQRMER
360 370 380 390 400
YHVAAAQAKA KGDQRKARMH ERIVKQYQDA IRAHKAGRAV DVAELPVPPG
410 420 430 440 450
FPPIQGLESA EPSQQSLVGV LETAMKLANH EEGSDEEEEE TPKKNTPAAS
460 470 480 490 500
TAQPKASPSR APPSGPAPAG KAASKGTSTR AQQQLAFLEG RKKQLLQAAL
510 520 530 540 550
RAKQKNDVEG AKMHLRQAKG LEPMLEASRN GLPVDIAKVP PAPVNKDDFV
560 570 580 590 600
LVQRPGPGMS QEAVRRYGEL TKLLRQQHEM CLNHSTQFTH LGNIAETIKF
610 620 630 640 650
EKLAEDCKRS MDTLKQAFAR SLPTPAARFE QRTFSVIKIF PDLSNNDMLL
660 670 680 690 700
FIVKGINLPT PPGLSPSDLD AFVRFDFPYP NVEEAQKDKT SVIKSTDSPE
710 720 730 740 750
FKEQFKLCIN RGHRGFRRAI QTKGIKFEVV HKGGLFKTDR VLGTAQLKLD
760 770 780 790 800
TLETACEVHE ILEVLDGRRP TGGRLEVMVR IREPLTAQQL ETTTERWLVI
810 820 830 840 850
DHIPAAVPTV TGPKAKVPLI PASSKEAGNR SSRPLHSLSV LAFDQERLER
860 870 880 890 900
KILALRQARR PVPPEVAQQY QDVVQRSQWQ RAQLEQGGAA LRREYASHLE
910 920 930 940
RQLHFYTEAA RRLGYDGSRE AAKEALYRRN LVESELQRLR R
Length:941
Mass (Da):103,587
Last modified:June 13, 2006 - v2
Checksum:i17A2DC070FC9217E
GO
Isoform 2 (identifier: Q66HA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-169: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):98,618
Checksum:i201A05B97015CEB2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019243125 – 169Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113552 Genomic DNA No translation available.
BC081948 mRNA Translation: AAH81948.1
RefSeqiNP_001013891.1, NM_001013869.1 [Q66HA5-2]
XP_006255296.1, XM_006255234.2 [Q66HA5-1]
UniGeneiRn.21651

Genome annotation databases

EnsembliENSRNOT00000009806; ENSRNOP00000009806; ENSRNOG00000006747 [Q66HA5-1]
ENSRNOT00000045180; ENSRNOP00000045667; ENSRNOG00000006747 [Q66HA5-2]
GeneIDi288908
KEGGirno:288908

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiC2D1A_RAT
AccessioniPrimary (citable) accession number: Q66HA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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