Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil and C2 domain-containing protein 1A

Gene

Cc2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil and C2 domain-containing protein 1A
Alternative name(s):
Five prime repressor element under dual repression-binding protein 1
Short name:
FRE under dual repression-binding protein 1
Short name:
Freud-1
Gene namesi
Name:Cc2d1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306108. Cc2d1a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • membrane Source: Ensembl
  • microtubule organizing center Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Coiled-coil and C2 domain-containing protein 1APRO_0000239611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphothreonineCombined sources
Modified residuei247 – 2471PhosphoserineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HA5.
PRIDEiQ66HA5.

Expressioni

Tissue specificityi

Strongly expressed in several brain areas including frontal cortex, cortex, mesencephalon, hippocampus, midbrain and hypothalamus. Also expressed in testis and at low levels in pituitary, liver and kidney. In brain the highest levels are detected in hippocampal pyramidal cells and raphe nuclei.1 Publication

Gene expression databases

GenevisibleiQ66HA5. RN.

Interactioni

Protein-protein interaction databases

IntActiQ66HA5. 1 interaction.
STRINGi10116.ENSRNOP00000009806.

Structurei

3D structure databases

ProteinModelPortaliQ66HA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini633 – 746114C2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili338 – 38447Sequence analysisAdd
BLAST
Coiled coili475 – 50834Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi304 – 33734Pro-richAdd
BLAST

Domaini

The C2 domain is required for the repression.By similarity

Sequence similaritiesi

Belongs to the CC2D1 family.Curated
Contains 1 C2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ66HA5.
KOiK18260.
OMAiMERYHVA.
OrthoDBiEOG71G9TB.
PhylomeDBiQ66HA5.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66HA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKRNGPQAP PGRGAVTARQ LGLLVDFSPD GLMIPEDGVN DEELEAEFLA
60 70 80 90 100
LVGGQPQALE KLKGKGPLPM EAIEKMARLC MRDLDEDEEG TDEDVEADED
110 120 130 140 150
LLAELNEVLG EERKAVEPAM PVVQPKPSSP NPGIEATLQE RLILYQSAVE
160 170 180 190 200
SARQAGDSAK MRRYDRGLKT LENLLVSAKK GNTINEADIP PPVASGKGPA
210 220 230 240 250
IGHSHTHTTS HLAPVSPPAP EPSVTLEAPS TTAQTSAKPQ LSPDPCSPLA
260 270 280 290 300
RLQSLQHEYK VAALRAKHQD DTATAARYLR VSKSFDPVLE ALSRGELVDL
310 320 330 340 350
SRLPPPPDQL SPEPPLPAAQ PVTPASTLTR PEVPQPPKNL LEALEQRMER
360 370 380 390 400
YHVAAAQAKA KGDQRKARMH ERIVKQYQDA IRAHKAGRAV DVAELPVPPG
410 420 430 440 450
FPPIQGLESA EPSQQSLVGV LETAMKLANH EEGSDEEEEE TPKKNTPAAS
460 470 480 490 500
TAQPKASPSR APPSGPAPAG KAASKGTSTR AQQQLAFLEG RKKQLLQAAL
510 520 530 540 550
RAKQKNDVEG AKMHLRQAKG LEPMLEASRN GLPVDIAKVP PAPVNKDDFV
560 570 580 590 600
LVQRPGPGMS QEAVRRYGEL TKLLRQQHEM CLNHSTQFTH LGNIAETIKF
610 620 630 640 650
EKLAEDCKRS MDTLKQAFAR SLPTPAARFE QRTFSVIKIF PDLSNNDMLL
660 670 680 690 700
FIVKGINLPT PPGLSPSDLD AFVRFDFPYP NVEEAQKDKT SVIKSTDSPE
710 720 730 740 750
FKEQFKLCIN RGHRGFRRAI QTKGIKFEVV HKGGLFKTDR VLGTAQLKLD
760 770 780 790 800
TLETACEVHE ILEVLDGRRP TGGRLEVMVR IREPLTAQQL ETTTERWLVI
810 820 830 840 850
DHIPAAVPTV TGPKAKVPLI PASSKEAGNR SSRPLHSLSV LAFDQERLER
860 870 880 890 900
KILALRQARR PVPPEVAQQY QDVVQRSQWQ RAQLEQGGAA LRREYASHLE
910 920 930 940
RQLHFYTEAA RRLGYDGSRE AAKEALYRRN LVESELQRLR R
Length:941
Mass (Da):103,587
Last modified:June 13, 2006 - v2
Checksum:i17A2DC070FC9217E
GO
Isoform 2 (identifier: Q66HA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-169: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):98,618
Checksum:i201A05B97015CEB2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 16945Missing in isoform 2. 1 PublicationVSP_019243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113552 Genomic DNA. No translation available.
BC081948 mRNA. Translation: AAH81948.1.
RefSeqiNP_001013891.1. NM_001013869.1. [Q66HA5-2]
XP_006255296.1. XM_006255234.2. [Q66HA5-1]
UniGeneiRn.21651.

Genome annotation databases

EnsembliENSRNOT00000009806; ENSRNOP00000009806; ENSRNOG00000006747. [Q66HA5-1]
ENSRNOT00000045180; ENSRNOP00000045667; ENSRNOG00000006747. [Q66HA5-2]
GeneIDi288908.
KEGGirno:288908.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113552 Genomic DNA. No translation available.
BC081948 mRNA. Translation: AAH81948.1.
RefSeqiNP_001013891.1. NM_001013869.1. [Q66HA5-2]
XP_006255296.1. XM_006255234.2. [Q66HA5-1]
UniGeneiRn.21651.

3D structure databases

ProteinModelPortaliQ66HA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ66HA5. 1 interaction.
STRINGi10116.ENSRNOP00000009806.

Proteomic databases

PaxDbiQ66HA5.
PRIDEiQ66HA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009806; ENSRNOP00000009806; ENSRNOG00000006747. [Q66HA5-1]
ENSRNOT00000045180; ENSRNOP00000045667; ENSRNOG00000006747. [Q66HA5-2]
GeneIDi288908.
KEGGirno:288908.

Organism-specific databases

CTDi54862.
RGDi1306108. Cc2d1a.

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ66HA5.
KOiK18260.
OMAiMERYHVA.
OrthoDBiEOG71G9TB.
PhylomeDBiQ66HA5.

Miscellaneous databases

NextBioi628945.
PROiQ66HA5.

Gene expression databases

GenevisibleiQ66HA5. RN.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  3. "Freud-1: a neuronal calcium-regulated repressor of the 5-HT1A receptor gene."
    Ou X.-M., Lemonde S., Jafar-Nejad H., Bown C.D., Goto A., Rogaeva A., Albert P.R.
    J. Neurosci. 23:7415-7425(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91 AND SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC2D1A_RAT
AccessioniPrimary (citable) accession number: Q66HA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 11, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.