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Protein

Caveolae-associated protein 2

Gene

Cavin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (By similarity). May play a role in targeting PRKCA to caveolae (PubMed:9566962).By similarity1 Publication

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 2Imported
Alternative name(s):
Cavin-2
Phosphatidylserine-binding protein
Serum deprivation-response protein
Gene namesi
Name:Cavin2Imported
Synonyms:SdprImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359345. Cavin2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002389202 – 417Caveolae-associated protein 2Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei195PhosphothreonineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei282PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1
Modified residuei286PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei292PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei387PhosphotyrosineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.By similarity
Phosphorylated on Ser residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ66H98.
PRIDEiQ66H98.

PTM databases

iPTMnetiQ66H98.
PhosphoSitePlusiQ66H98.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025895.
GenevisibleiQ66H98. RN.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN. Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (By similarity). Binds to PRKCA in the presence of phosphatidylserine (PubMed:9566962). Interacts with CAVIN1 and CAV3 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi261332. 1 interactor.
IntActiQ66H98. 1 interactor.
STRINGi10116.ENSRNOP00000030025.

Structurei

3D structure databases

SMRiQ66H98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 168Interaction with CAVIN1By similarityAdd BLAST167
Regioni62 – 100Leucine-zipperBy similarityAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 87Sequence analysisAdd BLAST27
Coiled coili126 – 267Sequence analysisAdd BLAST142

Domaini

The leucine-zipper domain is essential for its localization in the caveolae.By similarity

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEZA. Eukaryota.
ENOG410XP8W. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
HOVERGENiHBG056807.
InParanoidiQ66H98.
OMAiERMDRQC.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ66H98.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR033298. Cavin2.
IPR026752. Cavin_fam.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF10. PTHR15240:SF10. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDAAQAEK FQHPNTDMLQ EKPSNPSPMP SSTPSPSLNL GSTEEAIRDN
60 70 80 90 100
SQVNAVTVHT LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL
110 120 130 140 150
SKYQASTSNT VSKLLEKSRK VSAHTRAVRE RLEKQCVQVK RLENNHAQLL
160 170 180 190 200
RRNHFKVLIF QEESEIPASV FVKEPVPSTA EGKELADENK SLEETLHNVD
210 220 230 240 250
LSSDDELPGD EEALEDSAEE KMEESRAEKI KRSSLKKVDS LKKAFSRQNI
260 270 280 290 300
EKKMNKLGTK IVSVERREKI KKSLTPNHQK ASSGKSSPFK VSPLSFGRKK
310 320 330 340 350
IREGESSAEN ETKLEEQVQD DHEEGSFTEG LSEASLPSGL LEGSAEDAEK
360 370 380 390 400
SALRGNNSGV GSNADLTIEE DEEEESVALQ QAQQVRYESG YMLNSKEMEE
410
SSEKHVQAAV LHVDQTA
Length:417
Mass (Da):46,386
Last modified:January 23, 2007 - v3
Checksum:iCA138577B3A4A6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081956 mRNA. Translation: AAH81956.1.
RefSeqiNP_001007713.1. NM_001007712.1.
UniGeneiRn.203035.

Genome annotation databases

EnsembliENSRNOT00000028907; ENSRNOP00000030025; ENSRNOG00000025895.
GeneIDi316384.
KEGGirno:316384.
UCSCiRGD:1359345. rat.

Similar proteinsi

Entry informationi

Entry nameiCAVN2_RAT
AccessioniPrimary (citable) accession number: Q66H98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families