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Q66H98

- SDPR_RAT

UniProt

Q66H98 - SDPR_RAT

Protein

Serum deprivation-response protein

Gene

Sdpr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May play a role in targeting PRKCA to caveolae.1 Publication

    GO - Molecular functioni

    1. phosphatidylserine binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum deprivation-response protein
    Alternative name(s):
    Cavin-2
    Phosphatidylserine-binding protein
    Gene namesi
    Name:SdprImported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1359345. Sdpr.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Membranecaveola 1 Publication
    Note: Colocalizes with CAV1 to caveolae.

    GO - Cellular componenti

    1. caveola Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 417416Serum deprivation-response proteinPRO_0000238920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei217 – 2171PhosphoserineBy similarity
    Modified residuei287 – 2871PhosphoserineBy similarity
    Modified residuei292 – 2921PhosphoserineBy similarity
    Modified residuei358 – 3581PhosphoserineBy similarity
    Modified residuei362 – 3621PhosphoserineBy similarity

    Post-translational modificationi

    The N-terminus is blocked.By similarity
    Phosphorylated on Ser residues.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ66H98.
    PRIDEiQ66H98.

    PTM databases

    PhosphoSiteiQ66H98.

    Expressioni

    Gene expression databases

    GenevestigatoriQ66H98.

    Interactioni

    Subunit structurei

    Interacts with MURC; this augments the transactivation of NPPA by MURC By similarity. Binds to PRKCA in the presence of phosphatidylserine.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ66H98. 1 interaction.
    STRINGi10116.ENSRNOP00000030025.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili61 – 8727Sequence AnalysisAdd
    BLAST
    Coiled coili126 – 267142Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PTRF/SDPR family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG43691.
    GeneTreeiENSGT00530000063058.
    HOGENOMiHOG000293135.
    HOVERGENiHBG056807.
    InParanoidiQ66H98.
    OMAiERMDRQC.
    OrthoDBiEOG71G9VF.
    PhylomeDBiQ66H98.
    TreeFamiTF331031.

    Family and domain databases

    InterProiIPR026752. Cavin_fam.
    [Graphical view]
    PANTHERiPTHR15240. PTHR15240. 1 hit.
    PfamiPF15237. PTRF_SDPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66H98-1 [UniParc]FASTAAdd to Basket

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    MGEDAAQAEK FQHPNTDMLQ EKPSNPSPMP SSTPSPSLNL GSTEEAIRDN    50
    SQVNAVTVHT LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL 100
    SKYQASTSNT VSKLLEKSRK VSAHTRAVRE RLEKQCVQVK RLENNHAQLL 150
    RRNHFKVLIF QEESEIPASV FVKEPVPSTA EGKELADENK SLEETLHNVD 200
    LSSDDELPGD EEALEDSAEE KMEESRAEKI KRSSLKKVDS LKKAFSRQNI 250
    EKKMNKLGTK IVSVERREKI KKSLTPNHQK ASSGKSSPFK VSPLSFGRKK 300
    IREGESSAEN ETKLEEQVQD DHEEGSFTEG LSEASLPSGL LEGSAEDAEK 350
    SALRGNNSGV GSNADLTIEE DEEEESVALQ QAQQVRYESG YMLNSKEMEE 400
    SSEKHVQAAV LHVDQTA 417
    Length:417
    Mass (Da):46,386
    Last modified:January 23, 2007 - v3
    Checksum:iCA138577B3A4A6A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081956 mRNA. Translation: AAH81956.1.
    RefSeqiNP_001007713.1. NM_001007712.1.
    UniGeneiRn.203035.

    Genome annotation databases

    EnsembliENSRNOT00000028907; ENSRNOP00000030025; ENSRNOG00000025895.
    GeneIDi316384.
    KEGGirno:316384.
    UCSCiRGD:1359345. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081956 mRNA. Translation: AAH81956.1 .
    RefSeqi NP_001007713.1. NM_001007712.1.
    UniGenei Rn.203035.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q66H98. 1 interaction.
    STRINGi 10116.ENSRNOP00000030025.

    PTM databases

    PhosphoSitei Q66H98.

    Proteomic databases

    PaxDbi Q66H98.
    PRIDEi Q66H98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028907 ; ENSRNOP00000030025 ; ENSRNOG00000025895 .
    GeneIDi 316384.
    KEGGi rno:316384.
    UCSCi RGD:1359345. rat.

    Organism-specific databases

    CTDi 8436.
    RGDi 1359345. Sdpr.

    Phylogenomic databases

    eggNOGi NOG43691.
    GeneTreei ENSGT00530000063058.
    HOGENOMi HOG000293135.
    HOVERGENi HBG056807.
    InParanoidi Q66H98.
    OMAi ERMDRQC.
    OrthoDBi EOG71G9VF.
    PhylomeDBi Q66H98.
    TreeFami TF331031.

    Miscellaneous databases

    NextBioi 670796.
    PROi Q66H98.

    Gene expression databases

    Genevestigatori Q66H98.

    Family and domain databases

    InterProi IPR026752. Cavin_fam.
    [Graphical view ]
    PANTHERi PTHR15240. PTHR15240. 1 hit.
    Pfami PF15237. PTRF_SDPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    2. Cited for: FUNCTION, INTERACTION WITH PRKCA, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSDPR_RAT
    AccessioniPrimary (citable) accession number: Q66H98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3