Q66H98 (SDPR_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serum deprivation-response protein

Alternative name(s):
Cavin-2
Phosphatidylserine-binding protein

Gene names

Name:

Sdpr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in targeting PRKCA to caveolae. Ref.2
Subunit structure	Interacts with MURC; this augments the transactivation of NPPA by MURC By similarity. Binds to PRKCA in the presence of phosphatidylserine. Ref.2
Subcellular location	Cytoplasm › cytosol By similarity. Membrane › caveola. Note: Colocalizes with CAV1 to caveolae. Ref.2
Post-translational modification	The N-terminus is blocked By similarity. Phosphorylated on Ser residues By similarity.
Miscellaneous	Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine By similarity.
Sequence similarities	Belongs to the PTRF/SDPR family.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Domain	Coiled coil
Ligand	Lipid-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara caveola Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	phosphatidylserine binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 417	416	Serum deprivation-response protein		PRO_0000238920
Regions
	Coiled coil	61 – 87	27	Potential
	Coiled coil	126 – 267	142	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylglycine By similarity
	Modified residue	202	1	Phosphoserine By similarity
	Modified residue	203	1	Phosphoserine By similarity
	Modified residue	217	1	Phosphoserine By similarity
	Modified residue	287	1	Phosphoserine By similarity
	Modified residue	292	1	Phosphoserine By similarity
	Modified residue	358	1	Phosphoserine By similarity
	Modified residue	362	1	Phosphoserine By similarity
	Modified residue	367	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66H98 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: CA138577B3A4A6A0	FASTA	417	46,386
	10 20 30 40 50 60 MGEDAAQAEK FQHPNTDMLQ EKPSNPSPMP SSTPSPSLNL GSTEEAIRDN SQVNAVTVHT 70 80 90 100 110 120 LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL SKYQASTSNT VSKLLEKSRK 130 140 150 160 170 180 VSAHTRAVRE RLEKQCVQVK RLENNHAQLL RRNHFKVLIF QEESEIPASV FVKEPVPSTA 190 200 210 220 230 240 EGKELADENK SLEETLHNVD LSSDDELPGD EEALEDSAEE KMEESRAEKI KRSSLKKVDS 250 260 270 280 290 300 LKKAFSRQNI EKKMNKLGTK IVSVERREKI KKSLTPNHQK ASSGKSSPFK VSPLSFGRKK 310 320 330 340 350 360 IREGESSAEN ETKLEEQVQD DHEEGSFTEG LSEASLPSGL LEGSAEDAEK SALRGNNSGV 370 380 390 400 410 GSNADLTIEE DEEEESVALQ QAQQVRYESG YMLNSKEMEE SSEKHVQAAV LHVDQTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[2]	"Targeting of protein kinase Calpha to caveolae." Mineo C., Ying Y.-S., Chapline C., Jaken S., Anderson R.G.W. J. Cell Biol. 141:601-610(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PRKCA, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081956 mRNA. Translation: AAH81956.1.
IPI	IPI00362416.
RefSeq	NP_001007713.1. NM_001007712.1.
UniGene	Rn.203035.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q66H98. 1 interaction.
STRING	10116.ENSRNOP00000030025.
PTM databases
PhosphoSite	Q66H98.
Proteomic databases
PaxDb	Q66H98.
PRIDE	Q66H98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000028907; ENSRNOP00000030025; ENSRNOG00000025895.
GeneID	316384.
KEGG	rno:316384.
UCSC	RGD:1359345. rat.
Organism-specific databases
CTD	8436.
RGD	1359345. Sdpr.
Phylogenomic databases
eggNOG	NOG43691.
GeneTree	ENSGT00530000063058.
HOGENOM	HOG000293135.
HOVERGEN	HBG056807.
InParanoid	Q66H98.
OMA	YQASTSN.
OrthoDB	EOG4S4PGT.
Gene expression databases
Genevestigator	Q66H98.
GermOnline	ENSRNOG00000025895. Rattus norvegicus.
Family and domain databases
InterPro	IPR026752. Cavin_fam. [Graphical view]
PANTHER	PTHR15240. PTHR15240. 1 hit.
ProtoNet	Search...
Other
NextBio	670796.

Entry information

Entry name

SDPR_RAT

Accession

Primary (citable) accession number: Q66H98

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 60 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program