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Q66H98

- SDPR_RAT

UniProt

Q66H98 - SDPR_RAT

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Protein
Serum deprivation-response protein
Gene
Sdpr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in targeting PRKCA to caveolae.1 Publication

GO - Molecular functioni

  1. phosphatidylserine binding Source: UniProtKB
  2. protein binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum deprivation-response protein
Alternative name(s):
Cavin-2
Phosphatidylserine-binding protein
Gene namesi
Name:Sdpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1359345. Sdpr.

Subcellular locationi

Cytoplasmcytosol By similarity. Membranecaveola
Note: Colocalizes with CAV1 to caveolae.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. caveola Source: UniProtKB-SubCell
  3. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 417416Serum deprivation-response protein
PRO_0000238920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei217 – 2171Phosphoserine By similarity
Modified residuei287 – 2871Phosphoserine By similarity
Modified residuei292 – 2921Phosphoserine By similarity
Modified residuei358 – 3581Phosphoserine By similarity
Modified residuei362 – 3621Phosphoserine By similarity

Post-translational modificationi

The N-terminus is blocked By similarity.
Phosphorylated on Ser residues By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ66H98.
PRIDEiQ66H98.

PTM databases

PhosphoSiteiQ66H98.

Expressioni

Gene expression databases

GenevestigatoriQ66H98.

Interactioni

Subunit structurei

Interacts with MURC; this augments the transactivation of NPPA by MURC By similarity. Binds to PRKCA in the presence of phosphatidylserine.1 Publication

Protein-protein interaction databases

IntActiQ66H98. 1 interaction.
STRINGi10116.ENSRNOP00000030025.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 8727 Reviewed prediction
Add
BLAST
Coiled coili126 – 267142 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the PTRF/SDPR family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG43691.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
HOVERGENiHBG056807.
InParanoidiQ66H98.
OMAiERMDRQC.
OrthoDBiEOG71G9VF.
PhylomeDBiQ66H98.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H98-1 [UniParc]FASTAAdd to Basket

« Hide

MGEDAAQAEK FQHPNTDMLQ EKPSNPSPMP SSTPSPSLNL GSTEEAIRDN    50
SQVNAVTVHT LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL 100
SKYQASTSNT VSKLLEKSRK VSAHTRAVRE RLEKQCVQVK RLENNHAQLL 150
RRNHFKVLIF QEESEIPASV FVKEPVPSTA EGKELADENK SLEETLHNVD 200
LSSDDELPGD EEALEDSAEE KMEESRAEKI KRSSLKKVDS LKKAFSRQNI 250
EKKMNKLGTK IVSVERREKI KKSLTPNHQK ASSGKSSPFK VSPLSFGRKK 300
IREGESSAEN ETKLEEQVQD DHEEGSFTEG LSEASLPSGL LEGSAEDAEK 350
SALRGNNSGV GSNADLTIEE DEEEESVALQ QAQQVRYESG YMLNSKEMEE 400
SSEKHVQAAV LHVDQTA 417
Length:417
Mass (Da):46,386
Last modified:January 23, 2007 - v3
Checksum:iCA138577B3A4A6A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081956 mRNA. Translation: AAH81956.1.
RefSeqiNP_001007713.1. NM_001007712.1.
UniGeneiRn.203035.

Genome annotation databases

EnsembliENSRNOT00000028907; ENSRNOP00000030025; ENSRNOG00000025895.
GeneIDi316384.
KEGGirno:316384.
UCSCiRGD:1359345. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081956 mRNA. Translation: AAH81956.1 .
RefSeqi NP_001007713.1. NM_001007712.1.
UniGenei Rn.203035.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q66H98. 1 interaction.
STRINGi 10116.ENSRNOP00000030025.

PTM databases

PhosphoSitei Q66H98.

Proteomic databases

PaxDbi Q66H98.
PRIDEi Q66H98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028907 ; ENSRNOP00000030025 ; ENSRNOG00000025895 .
GeneIDi 316384.
KEGGi rno:316384.
UCSCi RGD:1359345. rat.

Organism-specific databases

CTDi 8436.
RGDi 1359345. Sdpr.

Phylogenomic databases

eggNOGi NOG43691.
GeneTreei ENSGT00530000063058.
HOGENOMi HOG000293135.
HOVERGENi HBG056807.
InParanoidi Q66H98.
OMAi ERMDRQC.
OrthoDBi EOG71G9VF.
PhylomeDBi Q66H98.
TreeFami TF331031.

Miscellaneous databases

NextBioi 670796.
PROi Q66H98.

Gene expression databases

Genevestigatori Q66H98.

Family and domain databases

InterProi IPR026752. Cavin_fam.
[Graphical view ]
PANTHERi PTHR15240. PTHR15240. 1 hit.
Pfami PF15237. PTRF_SDPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. Cited for: FUNCTION, INTERACTION WITH PRKCA, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSDPR_RAT
AccessioniPrimary (citable) accession number: Q66H98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi