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Q66H98 (SDPR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum deprivation-response protein
Alternative name(s):
Cavin-2
Phosphatidylserine-binding protein
Gene names
Name:Sdpr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in targeting PRKCA to caveolae. Ref.2

Subunit structure

Interacts with MURC; this augments the transactivation of NPPA by MURC By similarity. Binds to PRKCA in the presence of phosphatidylserine. Ref.2

Subcellular location

Cytoplasmcytosol By similarity. Membranecaveola. Note: Colocalizes with CAV1 to caveolae. Ref.2

Post-translational modification

The N-terminus is blocked By similarity.

Phosphorylated on Ser residues By similarity.

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine By similarity.

Sequence similarities

Belongs to the PTRF/SDPR family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 417416Serum deprivation-response protein
PRO_0000238920

Regions

Coiled coil61 – 8727 Potential
Coiled coil126 – 267142 Potential

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue2171Phosphoserine By similarity
Modified residue2871Phosphoserine By similarity
Modified residue2921Phosphoserine By similarity
Modified residue3581Phosphoserine By similarity
Modified residue3621Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66H98 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CA138577B3A4A6A0

FASTA41746,386
        10         20         30         40         50         60 
MGEDAAQAEK FQHPNTDMLQ EKPSNPSPMP SSTPSPSLNL GSTEEAIRDN SQVNAVTVHT 

        70         80         90        100        110        120 
LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL SKYQASTSNT VSKLLEKSRK 

       130        140        150        160        170        180 
VSAHTRAVRE RLEKQCVQVK RLENNHAQLL RRNHFKVLIF QEESEIPASV FVKEPVPSTA 

       190        200        210        220        230        240 
EGKELADENK SLEETLHNVD LSSDDELPGD EEALEDSAEE KMEESRAEKI KRSSLKKVDS 

       250        260        270        280        290        300 
LKKAFSRQNI EKKMNKLGTK IVSVERREKI KKSLTPNHQK ASSGKSSPFK VSPLSFGRKK 

       310        320        330        340        350        360 
IREGESSAEN ETKLEEQVQD DHEEGSFTEG LSEASLPSGL LEGSAEDAEK SALRGNNSGV 

       370        380        390        400        410 
GSNADLTIEE DEEEESVALQ QAQQVRYESG YMLNSKEMEE SSEKHVQAAV LHVDQTA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[2]"Targeting of protein kinase Calpha to caveolae."
Mineo C., Ying Y.-S., Chapline C., Jaken S., Anderson R.G.W.
J. Cell Biol. 141:601-610(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PRKCA, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081956 mRNA. Translation: AAH81956.1.
RefSeqNP_001007713.1. NM_001007712.1.
UniGeneRn.203035.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ66H98. 1 interaction.
STRING10116.ENSRNOP00000030025.

PTM databases

PhosphoSiteQ66H98.

Proteomic databases

PaxDbQ66H98.
PRIDEQ66H98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028907; ENSRNOP00000030025; ENSRNOG00000025895.
GeneID316384.
KEGGrno:316384.
UCSCRGD:1359345. rat.

Organism-specific databases

CTD8436.
RGD1359345. Sdpr.

Phylogenomic databases

eggNOGNOG43691.
GeneTreeENSGT00530000063058.
HOGENOMHOG000293135.
HOVERGENHBG056807.
InParanoidQ66H98.
OMAERMDRQC.
OrthoDBEOG71G9VF.
PhylomeDBQ66H98.
TreeFamTF331031.

Gene expression databases

GenevestigatorQ66H98.

Family and domain databases

InterProIPR026752. Cavin_fam.
[Graphical view]
PANTHERPTHR15240. PTHR15240. 1 hit.
PfamPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio670796.
PROQ66H98.

Entry information

Entry nameSDPR_RAT
AccessionPrimary (citable) accession number: Q66H98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families