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Protein

Calcium-binding protein 7

Gene

Cabp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi46 – 57121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi82 – 93122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 7
Short name:
CaBP7
Alternative name(s):
Calneuron II
Calneuron-2
Gene namesi
Name:Cabp7
Synonyms:Caln2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1359269. Cabp7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 188188CytoplasmicSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini210 – 2156ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Calcium-binding protein 7PRO_0000383472Add
BLAST

Proteomic databases

PaxDbiQ66H96.
PRIDEiQ66H96.

Expressioni

Tissue specificityi

Brain-specific. Restricted to the CA3 region of the hippocampus, entorhinal cortex, the antero-dorsal and antero-ventral thalamus and the inferior and superior colliculus.1 Publication

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010439.

Structurei

3D structure databases

ProteinModelPortaliQ66H96.
SMRiQ66H96. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini69 – 10436EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.By similarity

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
InParanoidiQ66H96.
OMAiCPVEVET.
OrthoDBiEOG74R1RQ.
PhylomeDBiQ66H96.
TreeFamiTF331025.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66H96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFHPVTAAL MYRGIYTVPN LLSEQRPVDI PEDELEEIRE AFKVFDRDGN
60 70 80 90 100
GFISKQELGT AMRSLGYMPN EVELEVIIQR LDMDGDGQVD FEEFVTLLGP
110 120 130 140 150
KLSTSGIPEK FHGTDFDTVF WKCDMQKLTV DELKRLLYDT FCEHLSMKDI
160 170 180 190 200
ENIIMTEEES HLGTAEECPV DVETCSNQQI RQTCVRKSLI CAFAIAFIIS
210
VMLIAANQVL RSGMK
Length:215
Mass (Da):24,453
Last modified:October 11, 2004 - v1
Checksum:i9C254C955F7AFFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY841152 mRNA. Translation: AAW21810.1.
BC081959 mRNA. Translation: AAH81959.1.
RefSeqiNP_001007731.1. NM_001007730.2.
UniGeneiRn.220068.

Genome annotation databases

EnsembliENSRNOT00000078179; ENSRNOP00000074795; ENSRNOG00000057703.
GeneIDi360970.
KEGGirno:360970.
UCSCiRGD:1359269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY841152 mRNA. Translation: AAW21810.1.
BC081959 mRNA. Translation: AAH81959.1.
RefSeqiNP_001007731.1. NM_001007730.2.
UniGeneiRn.220068.

3D structure databases

ProteinModelPortaliQ66H96.
SMRiQ66H96. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010439.

Proteomic databases

PaxDbiQ66H96.
PRIDEiQ66H96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078179; ENSRNOP00000074795; ENSRNOG00000057703.
GeneIDi360970.
KEGGirno:360970.
UCSCiRGD:1359269. rat.

Organism-specific databases

CTDi164633.
RGDi1359269. Cabp7.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00740000115520.
HOGENOMiHOG000252990.
InParanoidiQ66H96.
OMAiCPVEVET.
OrthoDBiEOG74R1RQ.
PhylomeDBiQ66H96.
TreeFamiTF331025.

Miscellaneous databases

NextBioi674754.
PROiQ66H96.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat calcium binding protein 7."
    Kim H., Hong S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: TISSUE SPECIFICITY.
  4. "Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking."
    Mikhaylova M., Reddy P.P., Munsch T., Landgraf P., Suman S.K., Smalla K.-H., Gundelfinger E.D., Sharma Y., Kreutz M.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:9093-9098(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PI4KB, FUNCTION.

Entry informationi

Entry nameiCABP7_RAT
AccessioniPrimary (citable) accession number: Q66H96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 11, 2004
Last modified: December 9, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The calcium-binding affinity is not regulated by magnesium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.