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Protein

Disrupted in renal carcinoma protein 2 homolog

Gene

Dirc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Electrogenic metabolite transporter.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Disrupted in renal carcinoma protein 2 homolog
Gene namesi
Name:Dirc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1310939. Dirc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 8917LumenalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1177CytoplasmicSequence analysis
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 15214LumenalSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 18411CytoplasmicSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 22924LumenalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Topological domaini251 – 28131CytoplasmicSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 31412LumenalSequence analysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence analysisAdd
BLAST
Topological domaini336 – 34712CytoplasmicSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38416LumenalSequence analysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST
Topological domaini406 – 4149CytoplasmicSequence analysis
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Topological domaini436 – 4427LumenalSequence analysis
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Topological domaini464 – 47815CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Disrupted in renal carcinoma protein 2 homologPRO_0000271340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ66H95.
PRIDEiQ66H95.

Expressioni

Gene expression databases

GenevisibleiQ66H95. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003048.

Structurei

3D structure databases

ProteinModelPortaliQ66H95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 152Mediates lysosomal localizationBy similarity

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
GeneTreeiENSGT00530000062892.
HOGENOMiHOG000294083.
HOVERGENiHBG060348.
InParanoidiQ66H95.
KOiK15381.
OMAiVLYAEFG.
OrthoDBiEOG79PJQ9.
PhylomeDBiQ66H95.
TreeFamiTF314292.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66H95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWSSEEE ERQPLLGPGL GPAPGATRRG REAAAVLPAA GPSPGRVYGR
60 70 80 90 100
RWLVLLLFSL LAFAQGLVWN TWGPIQNSAR QAYSFTGWDI ALLVLWGPIG
110 120 130 140 150
FLPCFAFMWL LDKRGLRITV LLTSFLMVLG TGLRCIPVSD LTLKKRLIHG
160 170 180 190 200
GQILNGLAGP TVMNAAPFLS TTWFSADERA TATAIASMLS YLGGACAFLV
210 220 230 240 250
GPLVVPAPNG TAPLLTAESS RDHIKDRIET VLYAEFGVVC LIFSATLAYF
260 270 280 290 300
PPRPPLPPSV AAASQRLSYR RSFCRLLSNL RFLMIALAYA IPLGVFAGWS
310 320 330 340 350
GVLDLILTPV HVSQVDAGWI GFWSIVGGCV VGIAMARFAD FIRGMLKLIL
360 370 380 390 400
LLLFSGATLS STWFTLTCLN SVTHLPLTTV TLYASCILLG VFLNSSVPIF
410 420 430 440 450
FELFVETVYP VPEGITCGVV TFLSNMFMGV LLFFVTFYHT ELSWFNWCLP
460 470
GSCLLSLLLI LCFRESYDRL YLDVVVSV
Length:478
Mass (Da):52,030
Last modified:October 11, 2004 - v1
Checksum:i0996DCDABA434DEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081960 mRNA. Translation: AAH81960.1.
RefSeqiNP_001012017.1. NM_001012017.1.
UniGeneiRn.137795.

Genome annotation databases

EnsembliENSRNOT00000003048; ENSRNOP00000003048; ENSRNOG00000002240.
GeneIDi303902.
KEGGirno:303902.
UCSCiRGD:1310939. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081960 mRNA. Translation: AAH81960.1.
RefSeqiNP_001012017.1. NM_001012017.1.
UniGeneiRn.137795.

3D structure databases

ProteinModelPortaliQ66H95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003048.

Proteomic databases

PaxDbiQ66H95.
PRIDEiQ66H95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003048; ENSRNOP00000003048; ENSRNOG00000002240.
GeneIDi303902.
KEGGirno:303902.
UCSCiRGD:1310939. rat.

Organism-specific databases

CTDi84925.
RGDi1310939. Dirc2.

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
GeneTreeiENSGT00530000062892.
HOGENOMiHOG000294083.
HOVERGENiHBG060348.
InParanoidiQ66H95.
KOiK15381.
OMAiVLYAEFG.
OrthoDBiEOG79PJQ9.
PhylomeDBiQ66H95.
TreeFamiTF314292.

Miscellaneous databases

PROiQ66H95.

Gene expression databases

GenevisibleiQ66H95. RN.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiDIRC2_RAT
AccessioniPrimary (citable) accession number: Q66H95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.