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Q66H94 (FKBP9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9

Short name=PPIase FKBP9
EC=5.2.1.8
Alternative name(s):
FK506-binding protein 9
Short name=FKBP-9
Rotamase
Gene names
Name:Fkbp9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506 By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 570546Peptidyl-prolyl cis-trans isomerase FKBP9
PRO_0000045761

Regions

Domain54 – 14289PPIase FKBP-type 1
Domain166 – 25489PPIase FKBP-type 2
Domain278 – 36588PPIase FKBP-type 3
Domain389 – 47789PPIase FKBP-type 4
Domain488 – 52336EF-hand 1
Domain533 – 56836EF-hand 2
Calcium binding501 – 512121 Potential
Calcium binding546 – 557122 Potential
Motif567 – 5704Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q66H94 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C4672322A367B310

FASTA57063,127
        10         20         30         40         50         60 
MAFGARGWRR WSLLLLLLWV TGQAAPVLGL AVSSELQIQR SFVPDECPRT VRSGDFVRYH 

        70         80         90        100        110        120 
YVGTFLDGQK FDSSYDRDST FSVFVGKGQL IAGMDQALVG MCVNERRFVT IPPNLAYGSE 

       130        140        150        160        170        180 
GVSGVIPPNS VLHFDVLLVD IWNSEDQVQI QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG 

       190        200        210        220        230        240 
TLFDSSHNRM KTYDTYVGIG WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EEGDGKDIPG 

       250        260        270        280        290        300 
QASLVFDVAL LDLHNPKDTI SVENKVVPES CERRSQSGDF LRYHYNGTLL DGTLFDSSYS 

       310        320        330        340        350        360 
RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEEGRGSIP GSAVLVFDIH 

       370        380        390        400        410        420 
VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL LDGTLLDSTW NLGKTYNIVL 

       430        440        450        460        470        480 
GFGQVVLGMD MGLREMCVGE KRTVIIPPHL GYGEAGVDGE VPGSAVLVFD IELLELVSGL 

       490        500        510        520        530        540 
PEGYMFIWNG EVSPNLFEEI DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFNAEMIVKN 

       550        560        570 
MFTNQDRNGD GKVTAEEFKL KDQETKHDEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081961 mRNA. Translation: AAH81961.1.
RefSeqNP_001007647.1. NM_001007646.1.
UniGeneRn.105976.

3D structure databases

ProteinModelPortalQ66H94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ66H94. 3 interactions.
STRING10116.ENSRNOP00000007821.

PTM databases

PhosphoSiteQ66H94.

Proteomic databases

PaxDbQ66H94.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007821; ENSRNOP00000007821; ENSRNOG00000005478.
GeneID297123.
KEGGrno:297123.
UCSCRGD:1549757. rat.

Organism-specific databases

CTD11328.
RGD1549757. Fkbp9.

Phylogenomic databases

eggNOGCOG0545.
GeneTreeENSGT00530000062784.
HOGENOMHOG000230960.
HOVERGENHBG051620.
InParanoidQ66H94.
KOK09575.
OMAEMIVKNM.
OrthoDBEOG7T1R9S.
PhylomeDBQ66H94.
TreeFamTF105296.

Gene expression databases

GenevestigatorQ66H94.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio642076.
PROQ66H94.

Entry information

Entry nameFKBP9_RAT
AccessionPrimary (citable) accession number: Q66H94
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families