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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

Fkbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi501 – 5121PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi546 – 5572PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:Fkbp9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1549757 Fkbp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004576125 – 570Peptidyl-prolyl cis-trans isomerase FKBP9Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ66H94
PRIDEiQ66H94

PTM databases

iPTMnetiQ66H94
PhosphoSitePlusiQ66H94

Expressioni

Gene expression databases

BgeeiENSRNOG00000005478
GenevisibleiQ66H94 RN

Interactioni

Protein-protein interaction databases

IntActiQ66H94, 3 interactors
STRINGi10116.ENSRNOP00000007821

Structurei

3D structure databases

ProteinModelPortaliQ66H94
SMRiQ66H94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 142PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini166 – 254PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini278 – 365PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini389 – 477PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini488 – 523EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini533 – 568EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi567 – 570Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000230960
HOVERGENiHBG051620
InParanoidiQ66H94
KOiK09575
OMAiEMIVKNM
OrthoDBiEOG091G02W1
PhylomeDBiQ66H94
TreeFamiTF105296

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 7 hits
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF00254 FKBP_C, 4 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGARGWRR WSLLLLLLWV TGQAAPVLGL AVSSELQIQR SFVPDECPRT
60 70 80 90 100
VRSGDFVRYH YVGTFLDGQK FDSSYDRDST FSVFVGKGQL IAGMDQALVG
110 120 130 140 150
MCVNERRFVT IPPNLAYGSE GVSGVIPPNS VLHFDVLLVD IWNSEDQVQI
160 170 180 190 200
QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG TLFDSSHNRM KTYDTYVGIG
210 220 230 240 250
WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EEGDGKDIPG QASLVFDVAL
260 270 280 290 300
LDLHNPKDTI SVENKVVPES CERRSQSGDF LRYHYNGTLL DGTLFDSSYS
310 320 330 340 350
RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEEGRGSIP
360 370 380 390 400
GSAVLVFDIH VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL
410 420 430 440 450
LDGTLLDSTW NLGKTYNIVL GFGQVVLGMD MGLREMCVGE KRTVIIPPHL
460 470 480 490 500
GYGEAGVDGE VPGSAVLVFD IELLELVSGL PEGYMFIWNG EVSPNLFEEI
510 520 530 540 550
DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFNAEMIVKN MFTNQDRNGD
560 570
GKVTAEEFKL KDQETKHDEL
Length:570
Mass (Da):63,127
Last modified:October 11, 2004 - v1
Checksum:iC4672322A367B310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081961 mRNA Translation: AAH81961.1
RefSeqiNP_001007647.1, NM_001007646.1
UniGeneiRn.105976

Genome annotation databases

EnsembliENSRNOT00000007821; ENSRNOP00000007821; ENSRNOG00000005478
GeneIDi297123
KEGGirno:297123
UCSCiRGD:1549757 rat

Similar proteinsi

Entry informationi

Entry nameiFKBP9_RAT
AccessioniPrimary (citable) accession number: Q66H94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health