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Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

Fkbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi501 – 512121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi546 – 557122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. FK506 binding Source: GO_Central
  3. peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_244670. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
Short name:
PPIase FKBP9
Alternative name(s):
FK506-binding protein 9
Short name:
FKBP-9
Rotamase
Gene namesi
Name:Fkbp9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1549757. Fkbp9.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 570546Peptidyl-prolyl cis-trans isomerase FKBP9PRO_0000045761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ66H94.

PTM databases

PhosphoSiteiQ66H94.

Expressioni

Gene expression databases

GenevestigatoriQ66H94.

Interactioni

Protein-protein interaction databases

IntActiQ66H94. 3 interactions.
STRINGi10116.ENSRNOP00000007821.

Structurei

3D structure databases

ProteinModelPortaliQ66H94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 14289PPIase FKBP-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 25489PPIase FKBP-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 36588PPIase FKBP-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 47789PPIase FKBP-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini488 – 52336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 56836EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi567 – 5704Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ66H94.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG7T1R9S.
PhylomeDBiQ66H94.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGARGWRR WSLLLLLLWV TGQAAPVLGL AVSSELQIQR SFVPDECPRT
60 70 80 90 100
VRSGDFVRYH YVGTFLDGQK FDSSYDRDST FSVFVGKGQL IAGMDQALVG
110 120 130 140 150
MCVNERRFVT IPPNLAYGSE GVSGVIPPNS VLHFDVLLVD IWNSEDQVQI
160 170 180 190 200
QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG TLFDSSHNRM KTYDTYVGIG
210 220 230 240 250
WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EEGDGKDIPG QASLVFDVAL
260 270 280 290 300
LDLHNPKDTI SVENKVVPES CERRSQSGDF LRYHYNGTLL DGTLFDSSYS
310 320 330 340 350
RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEEGRGSIP
360 370 380 390 400
GSAVLVFDIH VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL
410 420 430 440 450
LDGTLLDSTW NLGKTYNIVL GFGQVVLGMD MGLREMCVGE KRTVIIPPHL
460 470 480 490 500
GYGEAGVDGE VPGSAVLVFD IELLELVSGL PEGYMFIWNG EVSPNLFEEI
510 520 530 540 550
DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFNAEMIVKN MFTNQDRNGD
560 570
GKVTAEEFKL KDQETKHDEL
Length:570
Mass (Da):63,127
Last modified:October 11, 2004 - v1
Checksum:iC4672322A367B310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081961 mRNA. Translation: AAH81961.1.
RefSeqiNP_001007647.1. NM_001007646.1.
UniGeneiRn.105976.

Genome annotation databases

EnsembliENSRNOT00000007821; ENSRNOP00000007821; ENSRNOG00000005478.
GeneIDi297123.
KEGGirno:297123.
UCSCiRGD:1549757. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081961 mRNA. Translation: AAH81961.1.
RefSeqiNP_001007647.1. NM_001007646.1.
UniGeneiRn.105976.

3D structure databases

ProteinModelPortaliQ66H94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ66H94. 3 interactions.
STRINGi10116.ENSRNOP00000007821.

PTM databases

PhosphoSiteiQ66H94.

Proteomic databases

PaxDbiQ66H94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007821; ENSRNOP00000007821; ENSRNOG00000005478.
GeneIDi297123.
KEGGirno:297123.
UCSCiRGD:1549757. rat.

Organism-specific databases

CTDi11328.
RGDi1549757. Fkbp9.

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ66H94.
KOiK09575.
OMAiEMIVKNM.
OrthoDBiEOG7T1R9S.
PhylomeDBiQ66H94.
TreeFamiTF105296.

Enzyme and pathway databases

ReactomeiREACT_244670. Association of TriC/CCT with target proteins during biosynthesis.

Miscellaneous databases

NextBioi642076.
PROiQ66H94.

Gene expression databases

GenevestigatoriQ66H94.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiFKBP9_RAT
AccessioniPrimary (citable) accession number: Q66H94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.