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Q66H94

- FKBP9_RAT

UniProt

Q66H94 - FKBP9_RAT

Protein

Peptidyl-prolyl cis-trans isomerase FKBP9

Gene

Fkbp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi501 – 512121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi546 – 557122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP9 (EC:5.2.1.8)
    Short name:
    PPIase FKBP9
    Alternative name(s):
    FK506-binding protein 9
    Short name:
    FKBP-9
    Rotamase
    Gene namesi
    Name:Fkbp9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1549757. Fkbp9.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 570546Peptidyl-prolyl cis-trans isomerase FKBP9PRO_0000045761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ66H94.

    PTM databases

    PhosphoSiteiQ66H94.

    Expressioni

    Gene expression databases

    GenevestigatoriQ66H94.

    Interactioni

    Protein-protein interaction databases

    IntActiQ66H94. 3 interactions.
    STRINGi10116.ENSRNOP00000007821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66H94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 14289PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini166 – 25489PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 36588PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini389 – 47789PPIase FKBP-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini488 – 52336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini533 – 56836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi567 – 5704Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    GeneTreeiENSGT00530000062784.
    HOGENOMiHOG000230960.
    HOVERGENiHBG051620.
    InParanoidiQ66H94.
    KOiK09575.
    OMAiEMIVKNM.
    OrthoDBiEOG7T1R9S.
    PhylomeDBiQ66H94.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13202. EF-hand_5. 1 hit.
    PF00254. FKBP_C. 4 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66H94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFGARGWRR WSLLLLLLWV TGQAAPVLGL AVSSELQIQR SFVPDECPRT    50
    VRSGDFVRYH YVGTFLDGQK FDSSYDRDST FSVFVGKGQL IAGMDQALVG 100
    MCVNERRFVT IPPNLAYGSE GVSGVIPPNS VLHFDVLLVD IWNSEDQVQI 150
    QTYFKPPSCP RTIQVSDFVR YHYNGTFLDG TLFDSSHNRM KTYDTYVGIG 200
    WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EEGDGKDIPG QASLVFDVAL 250
    LDLHNPKDTI SVENKVVPES CERRSQSGDF LRYHYNGTLL DGTLFDSSYS 300
    RNHTFDTYIG QGYVIPGMDE GLLGVCIGER RRIVVPPHLG YGEEGRGSIP 350
    GSAVLVFDIH VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL 400
    LDGTLLDSTW NLGKTYNIVL GFGQVVLGMD MGLREMCVGE KRTVIIPPHL 450
    GYGEAGVDGE VPGSAVLVFD IELLELVSGL PEGYMFIWNG EVSPNLFEEI 500
    DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFNAEMIVKN MFTNQDRNGD 550
    GKVTAEEFKL KDQETKHDEL 570
    Length:570
    Mass (Da):63,127
    Last modified:October 11, 2004 - v1
    Checksum:iC4672322A367B310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081961 mRNA. Translation: AAH81961.1.
    RefSeqiNP_001007647.1. NM_001007646.1.
    UniGeneiRn.105976.

    Genome annotation databases

    EnsembliENSRNOT00000007821; ENSRNOP00000007821; ENSRNOG00000005478.
    GeneIDi297123.
    KEGGirno:297123.
    UCSCiRGD:1549757. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081961 mRNA. Translation: AAH81961.1 .
    RefSeqi NP_001007647.1. NM_001007646.1.
    UniGenei Rn.105976.

    3D structure databases

    ProteinModelPortali Q66H94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q66H94. 3 interactions.
    STRINGi 10116.ENSRNOP00000007821.

    PTM databases

    PhosphoSitei Q66H94.

    Proteomic databases

    PaxDbi Q66H94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007821 ; ENSRNOP00000007821 ; ENSRNOG00000005478 .
    GeneIDi 297123.
    KEGGi rno:297123.
    UCSCi RGD:1549757. rat.

    Organism-specific databases

    CTDi 11328.
    RGDi 1549757. Fkbp9.

    Phylogenomic databases

    eggNOGi COG0545.
    GeneTreei ENSGT00530000062784.
    HOGENOMi HOG000230960.
    HOVERGENi HBG051620.
    InParanoidi Q66H94.
    KOi K09575.
    OMAi EMIVKNM.
    OrthoDBi EOG7T1R9S.
    PhylomeDBi Q66H94.
    TreeFami TF105296.

    Miscellaneous databases

    NextBioi 642076.
    PROi Q66H94.

    Gene expression databases

    Genevestigatori Q66H94.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13202. EF-hand_5. 1 hit.
    PF00254. FKBP_C. 4 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiFKBP9_RAT
    AccessioniPrimary (citable) accession number: Q66H94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3