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Protein
Submitted name:

Bardet-Biedl syndrome 7

Gene

Bbs7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. brain development Source: Ensembl
  2. eye development Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. heart development Source: Ensembl
  5. limb development Source: Ensembl
  6. nonmotile primary cilium assembly Source: InterPro
  7. palate development Source: Ensembl
  8. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  9. protein localization Source: Ensembl
  10. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. smoothened signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_299206. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Submitted name:
Bardet-Biedl syndrome 7Imported
Submitted name:
Protein Bbs7Imported
Gene namesi
Name:Bbs7Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1309264. Bbs7.

Subcellular locationi

GO - Cellular componenti

  1. axoneme Source: Ensembl
  2. BBSome Source: Ensembl
  3. centrosome Source: Ensembl
  4. ciliary basal body Source: Ensembl
  5. membrane Source: Ensembl
  6. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ66H90.

Expressioni

Gene expression databases

GenevestigatoriQ66H90.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021453.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG72192.
GeneTreeiENSGT00390000012346.
HOGENOMiHOG000022374.
HOVERGENiHBG045408.
InParanoidiQ66H90.
KOiK16749.
OMAiKPIHKWE.
OrthoDBiEOG7CNZG6.
PhylomeDBiQ66H90.
TreeFamiTF315013.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016575. Bardet-Biedl_syndrome_7_prot.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PIRSFiPIRSF011091. BBS7. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q66H90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLTLSRADY LQVGVTSQKT MKLLPTSRQR ATQKVVIGDQ DGVVMCFGMK
60 70 80 90 100
KGEAVSVFKT LPGQKVSRLE LGGALNTPQE KIFIAAGSEI RGFTKRGKQF
110 120 130 140 150
LSFETNLTES IKAMYISGSD LFLSASYIYN HYCDCKDQNY YLSGDKINDV
160 170 180 190 200
ICLPVERLSR VTPVLACQDR VLRVLQGSDV TYEIEVPGPP TVLALHNGDG
210 220 230 240 250
GDSGEGLLFG TSDGRLGLIQ ITASKPIHKW EIRNDKKRGG ILCLDSFDIM
260 270 280 290 300
GDGVKDLLVG RDDGMVEVYS FENANEPVLR FDQMLSESVT SVQGGCVGKD
310 320 330 340 350
GYDEIVLATY SGWVTGLTTE PTHKESGPGE ELKLNQEMQN KIASLRTELE
360 370 380 390 400
HLQLKVLQER ENYQQSSQSS QAKSTVPSFS INDKFTLNKD DASYSLVLEV
410 420 430 440 450
RTAIDNVLIQ SDVPIDLLDV DKNSAVVSFS SCDTESNDNF LLATYRCQAN
460 470 480 490 500
TTRLELKIRS IEGQYGTLQA YVTPRIQPKT CQVRQYHIKP LSLHQRTHFI
510 520 530 540 550
DHDRPMNTLT LTGQFSFAEV HSWAVLCLPE VPEKPPAGEC ATFYFQNTFL
560 570 580 590 600
DTQLECAYRK GEGIFKSDNI STISILKDVL SKEATKRKIN LNISYEINEV
610 620 630 640 650
SVKHTLKLIH PKLEYQLLLA KKVQLIDALK ELQVHEGNTS FLIPEYRCIL
660 670 680 690 700
EEADHLQEEY KKQPAHLERL YGMITDLFID KFKFKGTNVK TKVPVLLEIL
710
DSYDQNTLIS FFDAA
Length:715
Mass (Da):80,167
Last modified:October 10, 2004 - v1
Checksum:iEE83F5BAA263C278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06015971 Genomic DNA. No translation available.
BC081968 mRNA. Translation: AAH81968.1.
RefSeqiNP_001012180.1. NM_001012180.1.
UniGeneiRn.28442.

Genome annotation databases

EnsembliENSRNOT00000021453; ENSRNOP00000021453; ENSRNOG00000015816.
GeneIDi361930.
KEGGirno:361930.
UCSCiRGD:1309264. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06015971 Genomic DNA. No translation available.
BC081968 mRNA. Translation: AAH81968.1.
RefSeqiNP_001012180.1. NM_001012180.1.
UniGeneiRn.28442.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021453.

Proteomic databases

PaxDbiQ66H90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021453; ENSRNOP00000021453; ENSRNOG00000015816.
GeneIDi361930.
KEGGirno:361930.
UCSCiRGD:1309264. rat.

Organism-specific databases

CTDi55212.
RGDi1309264. Bbs7.

Phylogenomic databases

eggNOGiNOG72192.
GeneTreeiENSGT00390000012346.
HOGENOMiHOG000022374.
HOVERGENiHBG045408.
InParanoidiQ66H90.
KOiK16749.
OMAiKPIHKWE.
OrthoDBiEOG7CNZG6.
PhylomeDBiQ66H90.
TreeFamiTF315013.

Enzyme and pathway databases

ReactomeiREACT_299206. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

NextBioi678090.
PROiQ66H90.

Gene expression databases

GenevestigatoriQ66H90.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016575. Bardet-Biedl_syndrome_7_prot.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PIRSFiPIRSF011091. BBS7. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ66H90_RAT
AccessioniPrimary (citable) accession number: Q66H90
Entry historyi
Integrated into UniProtKB/TrEMBL: October 10, 2004
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.