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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

Ankzf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 9425C2H2-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Gene namesi
Name:Ankzf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359242. Ankzf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Ankyrin repeat and zinc finger domain-containing protein 1PRO_0000247280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei256 – 2561PhosphoserineBy similarity
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei529 – 5291PhosphoserineBy similarity
Modified residuei603 – 6031PhosphothreonineBy similarity
Modified residuei676 – 6761PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66H85.
PRIDEiQ66H85.

PTM databases

iPTMnetiQ66H85.

Expressioni

Gene expression databases

GenevisibleiQ66H85. RN.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036500.

Structurei

3D structure databases

ProteinModelPortaliQ66H85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati489 – 51931ANK 1Add
BLAST
Repeati530 – 55930ANK 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni654 – 66613VCP/p97-interacting motif (VIM)By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili602 – 65554Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 9425C2H2-typeAdd
BLAST

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
GeneTreeiENSGT00390000005911.
HOGENOMiHOG000033947.
HOVERGENiHBG080842.
InParanoidiQ66H85.
OMAiLYTACKT.
OrthoDBiEOG7M6D7B.
PhylomeDBiQ66H85.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66H85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAPRAAPV PASVSLLTLN GEAPLVRGLS LVSQAPGEAL AWAPRTSCPG
60 70 80 90 100
ENTSSGRKVS PCSLDISDKL FCSACDQVFQ NHQEQREHYK LDWHRFNLKQ
110 120 130 140 150
RLKNKPLLSA SDFERQSSRG DLSSISGSED SDSASEEDLL TLDEERAESE
160 170 180 190 200
KPNRPPGFYP HRVLFRNAQG QFLYAYRCVL GPHQIPPEKA ELLLQNLQNG
210 220 230 240 250
GPRHYVVLMA AAGHFAGAIF QGREVVAHKT FHRYTVRAKR GTAQGLQDAQ
260 270 280 290 300
GRASRSAGAN LRRYNEAMLY KDVRDLLAGP TWSKALGEAE TILLHAPRSG
310 320 330 340 350
RSLFFGGQGA PLQRSDFRLW DIPLTTRRPT FGELQRVLHK LTTLQVYDED
360 370 380 390 400
PREMVRFHSP ETHCKPVREE RKRDTEKEKT KVPSDANKAL GQDEEPLKQG
410 420 430 440 450
SESQEEDGSE VELELVELTL GTLDLREFEV LPKRRKKRKK KERSQKQQCG
460 470 480 490 500
AHGPLLQQPQ DEPFSQPTQV VATPLDTLVD EAKAPGQPEL WDMLLAACRA
510 520 530 540 550
GEVEVLKLQL ATGPVDPGVM SLLSAPLGSG GFTLLHAAAA AGRGLVVRLL
560 570 580 590 600
LEAGADPTVH DSRARPPYTV AADRSTRNEF RRFMEKNLDA YDYSKARVPG
610 620 630 640 650
PLTQEMEARQ ATRKKEQKAA RRQREQQQRK QREQEEQEQE ERRRFAALSD
660 670 680 690 700
REKRALAAER RLAAQLGAPS PPVPDSAVVN AGRCWSCGVS LQGLIPFHYL
710 720
DFSFCSTRCL RDHRSQAGRP SS
Length:722
Mass (Da):80,585
Last modified:October 11, 2004 - v1
Checksum:iA6517030713C2212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081973 mRNA. Translation: AAH81973.1.
RefSeqiNP_001014241.1. NM_001014219.1.
UniGeneiRn.163073.

Genome annotation databases

EnsembliENSRNOT00000032419; ENSRNOP00000036500; ENSRNOG00000019052.
GeneIDi363255.
KEGGirno:363255.
UCSCiRGD:1359242. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081973 mRNA. Translation: AAH81973.1.
RefSeqiNP_001014241.1. NM_001014219.1.
UniGeneiRn.163073.

3D structure databases

ProteinModelPortaliQ66H85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036500.

PTM databases

iPTMnetiQ66H85.

Proteomic databases

PaxDbiQ66H85.
PRIDEiQ66H85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032419; ENSRNOP00000036500; ENSRNOG00000019052.
GeneIDi363255.
KEGGirno:363255.
UCSCiRGD:1359242. rat.

Organism-specific databases

CTDi55139.
RGDi1359242. Ankzf1.

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
GeneTreeiENSGT00390000005911.
HOGENOMiHOG000033947.
HOVERGENiHBG080842.
InParanoidiQ66H85.
OMAiLYTACKT.
OrthoDBiEOG7M6D7B.
PhylomeDBiQ66H85.

Miscellaneous databases

PROiQ66H85.

Gene expression databases

GenevisibleiQ66H85. RN.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiANKZ1_RAT
AccessioniPrimary (citable) accession number: Q66H85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.