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Q66H78

- ACPL2_RAT

UniProt

Q66H78 - ACPL2_RAT

Protein

Acid phosphatase-like protein 2

Gene

Acpl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971NucleophileBy similarity
    Active sitei379 – 3791Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase-like protein 2 (EC:3.1.3.2)
    Gene namesi
    Name:Acpl2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1359617. Acpl2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 480445Acid phosphatase-like protein 2PRO_0000314926Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ66H78.

    Expressioni

    Gene expression databases

    GenevestigatoriQ66H78.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017085.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66H78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG321954.
    GeneTreeiENSGT00390000016324.
    HOGENOMiHOG000033787.
    HOVERGENiHBG106056.
    InParanoidiQ66H78.
    OMAiCHNVSFP.
    OrthoDBiEOG747PJ2.
    PhylomeDBiQ66H78.
    TreeFamiTF318821.

    Family and domain databases

    Gene3Di3.40.50.1240. 2 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66H78-1 [UniParc]FASTAAdd to Basket

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    MLYRNRFLVL LALAGLLAFL SLSLQFFHLI PVSTTKNGGS SKSRKRIMPD    50
    PVTEPPTVDP VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR 100
    YPLYAIPKTK RPEIDCTLVA SRKPYHPKLE AFVGHMLKGS GASFESPLGS 150
    LPLYPNHPLC EMGELTQTGV VQHLQNGQLL RDIYLRKHKL LPNNWSSDQL 200
    YLETTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF CSGSCYCPLR 250
    NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 300
    HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH 350
    PILNQTVNRM QRAALGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA 400
    ARLVFELWQD RQKPSEHSVR ILYNGADVTF HTSFCHDFHK HSPKPMCPLE 450
    NLVRFVKRDM FVALDGSSTN YYDACHGEGA 480
    Length:480
    Mass (Da):54,958
    Last modified:October 11, 2004 - v1
    Checksum:i1A3168B91164A14E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081981 mRNA. Translation: AAH81981.1.
    RefSeqiNP_001007711.1. NM_001007710.1.
    XP_006243653.1. XM_006243591.1.
    XP_006243654.1. XM_006243592.1.
    XP_006243655.1. XM_006243593.1.
    UniGeneiRn.9589.

    Genome annotation databases

    EnsembliENSRNOT00000017085; ENSRNOP00000017085; ENSRNOG00000012480.
    GeneIDi315939.
    KEGGirno:315939.
    UCSCiRGD:1359617. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081981 mRNA. Translation: AAH81981.1 .
    RefSeqi NP_001007711.1. NM_001007710.1.
    XP_006243653.1. XM_006243591.1.
    XP_006243654.1. XM_006243592.1.
    XP_006243655.1. XM_006243593.1.
    UniGenei Rn.9589.

    3D structure databases

    ProteinModelPortali Q66H78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017085.

    Proteomic databases

    PRIDEi Q66H78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017085 ; ENSRNOP00000017085 ; ENSRNOG00000012480 .
    GeneIDi 315939.
    KEGGi rno:315939.
    UCSCi RGD:1359617. rat.

    Organism-specific databases

    CTDi 92370.
    RGDi 1359617. Acpl2.

    Phylogenomic databases

    eggNOGi NOG321954.
    GeneTreei ENSGT00390000016324.
    HOGENOMi HOG000033787.
    HOVERGENi HBG106056.
    InParanoidi Q66H78.
    OMAi CHNVSFP.
    OrthoDBi EOG747PJ2.
    PhylomeDBi Q66H78.
    TreeFami TF318821.

    Miscellaneous databases

    NextBioi 670088.
    PROi Q66H78.

    Gene expression databases

    Genevestigatori Q66H78.

    Family and domain databases

    Gene3Di 3.40.50.1240. 2 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiACPL2_RAT
    AccessioniPrimary (citable) accession number: Q66H78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3