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Q66H78 (ACPL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acid phosphatase-like protein 2
EC=3.1.3.2
Gene names
Name:Acpl2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 480445Acid phosphatase-like protein 2
PRO_0000314926

Sites

Active site971Nucleophile By similarity
Active site3791Proton donor By similarity

Amino acid modifications

Glycosylation3051N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q66H78 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1A3168B91164A14E

FASTA48054,958
        10         20         30         40         50         60 
MLYRNRFLVL LALAGLLAFL SLSLQFFHLI PVSTTKNGGS SKSRKRIMPD PVTEPPTVDP 

        70         80         90        100        110        120 
VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR YPLYAIPKTK RPEIDCTLVA 

       130        140        150        160        170        180 
SRKPYHPKLE AFVGHMLKGS GASFESPLGS LPLYPNHPLC EMGELTQTGV VQHLQNGQLL 

       190        200        210        220        230        240 
RDIYLRKHKL LPNNWSSDQL YLETTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF 

       250        260        270        280        290        300 
CSGSCYCPLR NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 

       310        320        330        340        350        360 
HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH PILNQTVNRM 

       370        380        390        400        410        420 
QRAALGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA ARLVFELWQD RQKPSEHSVR 

       430        440        450        460        470        480 
ILYNGADVTF HTSFCHDFHK HSPKPMCPLE NLVRFVKRDM FVALDGSSTN YYDACHGEGA

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC081981 mRNA. Translation: AAH81981.1.
IPIIPI00189334.
RefSeqNP_001007711.1. NM_001007710.1.
UniGeneRn.9589.

3D structure databases

HSSPHSSP built from PDB template 1ND5 based on UniProtKB P15309.
ProteinModelPortalQ66H78.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000017085.

Proteomic databases

PRIDEQ66H78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017085; ENSRNOP00000017085; ENSRNOG00000012480.
GeneID315939.
KEGGrno:315939.
UCSCRGD:1359617. rat.

Organism-specific databases

CTD92370.
RGD1359617. Acpl2.

Phylogenomic databases

eggNOGNOG321954.
GeneTreeENSGT00390000016324.
HOGENOMHOG000033787.
HOVERGENHBG106056.
InParanoidQ66H78.
OMACHNVSFP.
OrthoDBEOG4H19VM.

Gene expression databases

GenevestigatorQ66H78.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. False negative.
PS00778. HIS_ACID_PHOSPHAT_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio670088.

Entry information

Entry nameACPL2_RAT
AccessionPrimary (citable) accession number: Q66H78
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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