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Q66H78

- ACPL2_RAT

UniProt

Q66H78 - ACPL2_RAT

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Protein

Acid phosphatase-like protein 2

Gene
Acpl2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Nucleophile By similarity
Active sitei379 – 3791Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase-like protein 2 (EC:3.1.3.2)
Gene namesi
Name:Acpl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1359617. Acpl2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Chaini36 – 480445Acid phosphatase-like protein 2PRO_0000314926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ66H78.

Expressioni

Gene expression databases

GenevestigatoriQ66H78.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017085.

Structurei

3D structure databases

ProteinModelPortaliQ66H78.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG321954.
GeneTreeiENSGT00390000016324.
HOGENOMiHOG000033787.
HOVERGENiHBG106056.
InParanoidiQ66H78.
OMAiCHNVSFP.
OrthoDBiEOG747PJ2.
PhylomeDBiQ66H78.
TreeFamiTF318821.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H78-1 [UniParc]FASTAAdd to Basket

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MLYRNRFLVL LALAGLLAFL SLSLQFFHLI PVSTTKNGGS SKSRKRIMPD    50
PVTEPPTVDP VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR 100
YPLYAIPKTK RPEIDCTLVA SRKPYHPKLE AFVGHMLKGS GASFESPLGS 150
LPLYPNHPLC EMGELTQTGV VQHLQNGQLL RDIYLRKHKL LPNNWSSDQL 200
YLETTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF CSGSCYCPLR 250
NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 300
HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH 350
PILNQTVNRM QRAALGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA 400
ARLVFELWQD RQKPSEHSVR ILYNGADVTF HTSFCHDFHK HSPKPMCPLE 450
NLVRFVKRDM FVALDGSSTN YYDACHGEGA 480
Length:480
Mass (Da):54,958
Last modified:October 11, 2004 - v1
Checksum:i1A3168B91164A14E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081981 mRNA. Translation: AAH81981.1.
RefSeqiNP_001007711.1. NM_001007710.1.
XP_006243653.1. XM_006243591.1.
XP_006243654.1. XM_006243592.1.
XP_006243655.1. XM_006243593.1.
UniGeneiRn.9589.

Genome annotation databases

EnsembliENSRNOT00000017085; ENSRNOP00000017085; ENSRNOG00000012480.
GeneIDi315939.
KEGGirno:315939.
UCSCiRGD:1359617. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081981 mRNA. Translation: AAH81981.1 .
RefSeqi NP_001007711.1. NM_001007710.1.
XP_006243653.1. XM_006243591.1.
XP_006243654.1. XM_006243592.1.
XP_006243655.1. XM_006243593.1.
UniGenei Rn.9589.

3D structure databases

ProteinModelPortali Q66H78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017085.

Proteomic databases

PRIDEi Q66H78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017085 ; ENSRNOP00000017085 ; ENSRNOG00000012480 .
GeneIDi 315939.
KEGGi rno:315939.
UCSCi RGD:1359617. rat.

Organism-specific databases

CTDi 315939.
RGDi 1359617. Acpl2.

Phylogenomic databases

eggNOGi NOG321954.
GeneTreei ENSGT00390000016324.
HOGENOMi HOG000033787.
HOVERGENi HBG106056.
InParanoidi Q66H78.
OMAi CHNVSFP.
OrthoDBi EOG747PJ2.
PhylomeDBi Q66H78.
TreeFami TF318821.

Miscellaneous databases

NextBioi 670088.
PROi Q66H78.

Gene expression databases

Genevestigatori Q66H78.

Family and domain databases

Gene3Di 3.40.50.1240. 2 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiACPL2_RAT
AccessioniPrimary (citable) accession number: Q66H78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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