ID   IL33_RAT                Reviewed;         264 AA.
AC   Q66H70;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   19-JAN-2010, entry version 39.
DE   RecName: Full=Interleukin-33;
DE            Short=IL-33;
DE   Flags: Precursor;
GN   Name=Il33;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2
CC       and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6,
CC       followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,
CC       MAPK14, and MAPK8. Induces T helper type 2-associated cytokines
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- PTM: Proteolytically converted to a mature form by CASP1 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the IL-1 family. Highly divergent.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC081993; AAH81993.1; -; mRNA.
DR   IPI; IPI00471802; -.
DR   RefSeq; NP_001014188.1; -.
DR   UniGene; Rn.106849; -.
DR   STRING; Q66H70; -.
DR   Ensembl; ENSRNOT00000022056; ENSRNOP00000022056; ENSRNOG00000016456; Rattus norvegicus.
DR   GeneID; 361749; -.
DR   KEGG; rno:361749; -.
DR   UCSC; NM_001014166; rat.
DR   CTD; 361749; -.
DR   RGD; 1311155; Il33.
DR   eggNOG; roNOG06681; -.
DR   HOVERGEN; Q66H70; -.
DR   InParanoid; Q66H70; -.
DR   NextBio; 677492; -.
DR   ArrayExpress; Q66H70; -.
DR   Genevestigator; Q66H70; -.
DR   GermOnline; ENSRNOG00000016456; Rattus norvegicus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008996; Cytokine_IL1-like.
PE   2: Evidence at transcript level;
KW   Cytokine; Secreted.
FT   PROPEP        1      ?       Potential.
FT                                /FTId=PRO_0000248848.
FT   CHAIN         ?    264       Interleukin-33.
FT                                /FTId=PRO_0000096793.
SQ   SEQUENCE   264 AA;  29486 MW;  91452ADC579B7BCC CRC64;
     MRPRMKYSNS KISPAKCDST SGRALVPPCK ITRSQQKTKD ICHVYCMRLR SGLTIRKETC
     YFGKEPAKRY SLKSGSKHEG RLSTCLPDSR KRSLLGSIQA FAASVDTLSI QGTSLLTESC
     ALSTYNDQSV SFVLENGCYV INVEDCGKNQ EKDKVLLRYY ESSFPAQSGD GVDGKKLMVN
     MSPIKDTDIW LNANDKDYSV ELQKGDVSPP DQAFFVLHKK SSDFVSFECK NLPGTYIGVK
     DNQLALVEEN DESCNNIMFK LSKM
//