Reviewed, UniProtKB/Swiss-Prot Q66H70 (IL33_RAT)

Names and origin

Protein names

Recommended name:
    Interleukin-33
      Short name=IL-33

Gene names

Name:

Il33

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	Proteolytically converted to a mature form by CASP1 By similarity.
Sequence similarities	Belongs to the IL-1 family. Highly divergent.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – ?		Potential		PRO_0000248848
	Chain	? – 264		Interleukin-33		PRO_0000096793

Sequences

	Sequence		Length	Mass (Da)
	Q66H70-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 91452ADC579B7BCC	FASTA	264	29,486
	10 20 30 40 50 60 MRPRMKYSNS KISPAKCDST SGRALVPPCK ITRSQQKTKD ICHVYCMRLR SGLTIRKETC 70 80 90 100 110 120 YFGKEPAKRY SLKSGSKHEG RLSTCLPDSR KRSLLGSIQA FAASVDTLSI QGTSLLTESC 130 140 150 160 170 180 ALSTYNDQSV SFVLENGCYV INVEDCGKNQ EKDKVLLRYY ESSFPAQSGD GVDGKKLMVN 190 200 210 220 230 240 MSPIKDTDIW LNANDKDYSV ELQKGDVSPP DQAFFVLHKK SSDFVSFECK NLPGTYIGVK 250 260 DNQLALVEEN DESCNNIMFK LSKM

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081993 mRNA. Translation: AAH81993.1.
IPI	IPI00471802.
RefSeq	NP_001014188.1.
UniGene	Rn.106849
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q66H70.
Genome annotation databases
Ensembl	ENSRNOT00000022056; ENSRNOP00000022056; ENSRNOG00000016456; Rattus norvegicus. [Genome view]
GeneID	361749.
KEGG	rno:361749.
UCSC	NM_001014166. rat.
Organism-specific databases
CTD	361749.
RGD	1311155. Il33.
Phylogenomic databases
eggNOG	roNOG06681.
HOVERGEN	Q66H70.
InParanoid	Q66H70.
Gene expression databases
ArrayExpress	Q66H70.
Genevestigator	Q66H70.
GermOnline	ENSRNOG00000016456. Rattus norvegicus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	677492.

Entry information

Entry name

IL33_RAT

Accession

Primary (citable) accession number: Q66H70

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 11, 2004
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)