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Reviewed, UniProtKB/Swiss-Prot Q66H62 (CYLD_RAT)

Last modified October 13, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable ubiquitin carboxyl-terminal hydrolase CYLD
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase CYLD
    Ubiquitin-specific-processing protease CYLD
    Deubiquitinating enzyme CYLD
Gene names
Name: Cyld
Synonyms: Cyld1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF-kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6 By similarity.

Catalytic activity

Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.

Subunit structure

Interacts with NEMO, TRAF2 and TRIP By similarity.

Subcellular location

Cytoplasm › perinuclear region By similarity.

Sequence similarities

Belongs to the peptidase C67 family.

Contains 2 CAP-Gly domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 953953Probable ubiquitin carboxyl-terminal hydrolase CYLD
PRO_0000326149

Regions

Domain153 – 19846CAP-Gly 1
Domain489 – 53244CAP-Gly 2
Region106 – 590485Interaction with TRIP By similarity
Region391 – 46676Interaction with TRAF2 By similarity
Region467 – 681215Interaction with NEMO By similarity

Sites

Active site5981 By similarity
Active site8681 By similarity

Amino acid modifications

Modified residue3961Phosphoserine By similarity
Modified residue4151Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q66H62-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 573B59E9BD795252

FASTA953106,713
        10         20         30         40         50         60 
MSSGLWNQEK VTSPYWEERL FYLLLQECSV TDKQTQKLLR VPKGSIGQYI QDRSVGHSRV 

        70         80         90        100        110        120 
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERL SLFRNRIRLS 

       130        140        150        160        170        180 
KGLQVDVGSP VRVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV 

       190        200        210        220        230        240 
YQGKQLFQCD EDCGVFVALD KLELIEDDDN GLESDFAGPG DTVQVEPPPL EINSRVSLKV 

       250        260        270        280        290        300 
GESTESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAS VESTVLLHIN 

       310        320        330        340        350        360 
DIIPDSVTQE RRPPKLAFMS RGVGDKGSSS HNKPKVTGST SDPGSRNRSE LFYTLNGSSV 

       370        380        390        400        410        420 
DSQQQSKSKN PWYIDEVAED PAKSLTEMSS DFGHSSPPPQ PPSMNSLSSE NRFHSLPFSL 

       430        440        450        460        470        480 
TKMPNTNGSM AHSPLSLSVQ SVMGELNSTP VQESPPMPSS SGNAHGLEVG SLAEVKENPP 

       490        500        510        520        530        540 
FYGVIRWIGQ PPGLSDVLAG LELEDECAGC TDGTFRGTRY FTCALKKALF VKLKSCRPDS 

       550        560        570        580        590        600 
RFASLQPVSN QIERCNSLAF GGYLSEVVEE NTPPKMEKEG LEIMIGKKKG IQGHYNSCYL 

       610        620        630        640        650        660 
DSTLFCLFAF SSALDTVLLR PKEKNDVEYY SETQELLRTE IVNPLRIYGY VCATKIMKLR 

       670        680        690        700        710        720 
KILEKVEAAS GFTSEEKDPE EFLNILFHDI LRVEPLLKIR SAGQKVQDCN FYQIFMEKNE 

       730        740        750        760        770        780 
KVGVPTIQQL LEWSFINSNL KFAEAPSCLI IQMPRFGKDF KLFKKIFPSL ELNITDLLED 

       790        800        810        820        830        840 
TPRQCRICGG LAMYECRECY DDPDISAGKI KQFCKTCSTQ VHLHPRRLNH TYHPVSLPKD 

       850        860        870        880        890        900 
LPDWDWRHGC IPCQKMELFA VLCIETSHYV AFVKYGKDDS AWLFFDSMAD RDGGQNGFNI 

       910        920        930        940        950 
PQVTPCPEVG EYLKMSLEDL HSLDSRRIQG CARRLLCDAY MCMYQSPTMS LYK

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

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Cross-references

Sequence databases

BC082001 mRNA. Translation: AAH82001.1.
IPIIPI00778627.
RefSeqNP_001017380.1.
XP_001063098.1.
UniGeneRn.128760
Rn.168938

3D structure databases

SMRQ66H62. Positions 125-206, 228-306, 462-547.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ66H62.

Protein family/group databases

MEROPSC67.001.

Genome annotation databases

EnsemblENSRNOT00000039357; ENSRNOP00000034744; ENSRNOG00000014048; Rattus norvegicus. [Genome view]
ENSRNOT00000060790; ENSRNOP00000057518; ENSRNOG00000014048; Rattus norvegicus. [Genome view]
GeneID312937.
KEGGrno:312937.
UCSCBC082001. rat.

Organism-specific databases

CTD312937.
RGD1308346. Cyld.

Phylogenomic databases

HOVERGENQ66H62.

Enzyme and pathway databases

BRENDA3.1.2.15. 248.

Gene expression databases

ArrayExpressQ66H62.
GenevestigatorQ66H62.

Family and domain databases

InterProIPR000938. Cytoskel-assoc-prot_CAP-Gly.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR001593. Ribosomal_S3Ae.
[Graphical view]
PANTHERPTHR11830. Ribosomal_S3AE. 1 hit.
PfamPF01302. CAP_GLY. 3 hits.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 2 hits.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. False negative.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio665399.

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Entry information

Entry nameCYLD_RAT
AccessionPrimary (citable) accession number: Q66H62
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2004
Last modified: October 13, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents