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Protein

High mobility group nucleosome-binding domain-containing protein 3

Gene

Hmgn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 3
Gene namesi
Name:Hmgn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359106 Hmgn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325771 – 95High mobility group nucleosome-binding domain-containing protein 3Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66H40
PRIDEiQ66H40

PTM databases

iPTMnetiQ66H40
PhosphoSitePlusiQ66H40

Expressioni

Gene expression databases

BgeeiENSRNOG00000031032
ExpressionAtlasiQ66H40 baseline and differential
GenevisibleiQ66H40 RN

Interactioni

Subunit structurei

Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes (By similarity).By similarity

Protein-protein interaction databases

BioGridi250246, 1 interactor
STRINGi10116.ENSRNOP00000066015

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J0Z7 Eukaryota
ENOG410YTHP LUCA
GeneTreeiENSGT00730000111287
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiQ66H40
KOiK11301
PhylomeDBiQ66H40

Family and domain databases

InterProiView protein in InterPro
IPR031073 HMGN3
IPR000079 HMGN_fam
PANTHERiPTHR23087:SF2 PTHR23087:SF2, 1 hit
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

Q66H40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKSPENA EGKDGAKLTK QEPTRRSARL SAKPVPPKPE PKPRKTSAKK
60 70 80 90
EPGTKINRAA KGKKEEKQEA GKEGTAPSAN GDTKAEEVLS TNASH
Length:95
Mass (Da):10,183
Last modified:October 11, 2004 - v1
Checksum:iFCC76474258624B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082036 mRNA Translation: AAH82036.1
RefSeqiNP_001007021.1, NM_001007020.2
NP_001188282.1, NM_001201353.1
NP_001188283.1, NM_001201354.1
NP_001188284.1, NM_001201355.1
UniGeneiRn.106652

Genome annotation databases

EnsembliENSRNOT00000039917; ENSRNOP00000043980; ENSRNOG00000031032
GeneIDi113990
KEGGirno:113990
UCSCiRGD:1359106 rat

Similar proteinsi

Entry informationi

Entry nameiHMGN3_RAT
AccessioniPrimary (citable) accession number: Q66H40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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