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Protein

High mobility group nucleosome-binding domain-containing protein 3

Gene

Hmgn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 3
Gene namesi
Name:Hmgn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359106. Hmgn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325771 – 95High mobility group nucleosome-binding domain-containing protein 3Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66H40.
PRIDEiQ66H40.

PTM databases

iPTMnetiQ66H40.
PhosphoSitePlusiQ66H40.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031032.
ExpressionAtlasiQ66H40. baseline and differential.
GenevisibleiQ66H40. RN.

Interactioni

Subunit structurei

Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes (By similarity).By similarity

Protein-protein interaction databases

BioGridi250246. 1 interactor.
STRINGi10116.ENSRNOP00000066015.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J0Z7. Eukaryota.
ENOG410YTHP. LUCA.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ66H40.
KOiK11301.
PhylomeDBiQ66H40.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66H40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKSPENA EGKDGAKLTK QEPTRRSARL SAKPVPPKPE PKPRKTSAKK
60 70 80 90
EPGTKINRAA KGKKEEKQEA GKEGTAPSAN GDTKAEEVLS TNASH
Length:95
Mass (Da):10,183
Last modified:October 11, 2004 - v1
Checksum:iFCC76474258624B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082036 mRNA. Translation: AAH82036.1.
RefSeqiNP_001007021.1. NM_001007020.2.
NP_001188282.1. NM_001201353.1.
NP_001188283.1. NM_001201354.1.
NP_001188284.1. NM_001201355.1.
UniGeneiRn.106652.

Genome annotation databases

EnsembliENSRNOT00000039917; ENSRNOP00000043980; ENSRNOG00000031032.
GeneIDi113990.
KEGGirno:113990.
UCSCiRGD:1359106. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082036 mRNA. Translation: AAH82036.1.
RefSeqiNP_001007021.1. NM_001007020.2.
NP_001188282.1. NM_001201353.1.
NP_001188283.1. NM_001201354.1.
NP_001188284.1. NM_001201355.1.
UniGeneiRn.106652.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250246. 1 interactor.
STRINGi10116.ENSRNOP00000066015.

PTM databases

iPTMnetiQ66H40.
PhosphoSitePlusiQ66H40.

Proteomic databases

PaxDbiQ66H40.
PRIDEiQ66H40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039917; ENSRNOP00000043980; ENSRNOG00000031032.
GeneIDi113990.
KEGGirno:113990.
UCSCiRGD:1359106. rat.

Organism-specific databases

CTDi9324.
RGDi1359106. Hmgn3.

Phylogenomic databases

eggNOGiENOG410J0Z7. Eukaryota.
ENOG410YTHP. LUCA.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ66H40.
KOiK11301.
PhylomeDBiQ66H40.

Miscellaneous databases

PROiQ66H40.

Gene expression databases

BgeeiENSRNOG00000031032.
ExpressionAtlasiQ66H40. baseline and differential.
GenevisibleiQ66H40. RN.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN3_RAT
AccessioniPrimary (citable) accession number: Q66H40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.