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Protein

Mitoferrin-1

Gene

Slc25a37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Solute carrier family 25 member 37
Gene namesi
Name:Slc25a37
Synonyms:Mfrn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359361. Slc25a37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 64Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei106 – 125Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei143 – 162Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei200 – 219Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei234 – 253Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei301 – 320Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352531 – 338Mitoferrin-1Add BLAST338

Proteomic databases

PaxDbiQ66H23.
PRIDEiQ66H23.

PTM databases

PhosphoSitePlusiQ66H23.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015495.
GenevisibleiQ66H23. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021636.

Structurei

3D structure databases

ProteinModelPortaliQ66H23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 131Solcar 1Add BLAST89
Repeati141 – 225Solcar 2Add BLAST85
Repeati232 – 326Solcar 3Add BLAST95

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ66H23.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ66H23.
TreeFamiTF314118.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66H23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRRGGVGS QAAGRRMDGD CRDGGCGSKD AGSEDYENLP TSASVSTHMT
60 70 80 90 100
AGAMAGILEH SIMYPVDSVK TRMQSLNPDP KARYTSIYGA LKRIMHTEGF
110 120 130 140 150
WRPLRGLNVM MMGAGPAHAM YFACYENMKR TLNDVFSHQG NSHLANGIAG
160 170 180 190 200
SMATLLHDAV MNPAEVVKQR LQMYNSQHQS ALSCIRTVWR TEGLGAFYRS
210 220 230 240 250
YTTQLTMNIP FQSIHFITYE FLQEQVNPRR DYNPQSHIIS GGLAGALAAA
260 270 280 290 300
ATTPLDVCKT LLNTQENMAL SLANVSGRLS GMANAFRTVY QLNGLAGYFK
310 320 330
GIQARVIYQM PSTAISWSVY EFFKYFLTKR QLENRTLY
Length:338
Mass (Da):37,497
Last modified:October 11, 2004 - v1
Checksum:iC5F6DE138530700E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082071 mRNA. Translation: AAH82071.1.
RefSeqiNP_001014018.1. NM_001013996.1.
UniGeneiRn.102664.

Genome annotation databases

EnsembliENSRNOT00000021636; ENSRNOP00000021636; ENSRNOG00000015495.
GeneIDi306000.
KEGGirno:306000.
UCSCiRGD:1359361. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082071 mRNA. Translation: AAH82071.1.
RefSeqiNP_001014018.1. NM_001013996.1.
UniGeneiRn.102664.

3D structure databases

ProteinModelPortaliQ66H23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021636.

PTM databases

PhosphoSitePlusiQ66H23.

Proteomic databases

PaxDbiQ66H23.
PRIDEiQ66H23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021636; ENSRNOP00000021636; ENSRNOG00000015495.
GeneIDi306000.
KEGGirno:306000.
UCSCiRGD:1359361. rat.

Organism-specific databases

CTDi51312.
RGDi1359361. Slc25a37.

Phylogenomic databases

eggNOGiKOG0760. Eukaryota.
ENOG410XNT2. LUCA.
GeneTreeiENSGT00550000074721.
HOGENOMiHOG000038810.
HOVERGENiHBG079464.
InParanoidiQ66H23.
KOiK15113.
OMAiPRRDYNP.
OrthoDBiEOG091G0PU8.
PhylomeDBiQ66H23.
TreeFamiTF314118.

Miscellaneous databases

PROiQ66H23.

Gene expression databases

BgeeiENSRNOG00000015495.
GenevisibleiQ66H23. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFRN1_RAT
AccessioniPrimary (citable) accession number: Q66H23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.