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Protein

Cholinephosphotransferase 1

Gene

Chpt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity).By similarity

Catalytic activityi

CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.

Cofactori

Mg2+By similarity, Mn2+By similarity

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Choline-phosphate cytidylyltransferase B (Pcyt1b), Choline-phosphate cytidylyltransferase A (Pcyt1a)
  2. Choline/ethanolaminephosphotransferase 1 (Cept1), Cholinephosphotransferase 1 (Chpt1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
UniPathwayiUPA00753; UER00740.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinephosphotransferase 1 (EC:2.7.8.2)
Alternative name(s):
Diacylglycerol cholinephosphotransferase 1
Gene namesi
Name:Chpt1
Synonyms:Cpt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359283. Chpt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 398397Cholinephosphotransferase 1PRO_0000289254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ66H21.
PRIDEiQ66H21.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005487.
GenevisibleiQ66H21. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000230699.
HOVERGENiHBG107647.
InParanoidiQ66H21.
KOiK00994.
OMAiMAPNSIT.
OrthoDBiEOG091G07XY.
PhylomeDBiQ66H21.
TreeFamiTF313270.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGAGARPA PRWVKALGEP LSAAQLRRLE DHRYSAAGES LFEPPLQLFW
60 70 80 90 100
TWLLQWIPLW IAPNTITLFG LAINLFTTLV LIFYCPTVTE EAPYWTYLLC
110 120 130 140 150
ALGLFIYQSL DAIDGKQARR TNSCSPLGEL FDHGCDSLST VFMAIGASIA
160 170 180 190 200
VRLGTHPDWL FFCSFVGMFM FYCAHWQTYV SGVLRFGRVD VTEIQVALVI
210 220 230 240 250
VFLLSTFGGA MMWDYTIPIL EIKLKILPVL GVVGGLIFSC SNYFHVILHG
260 270 280 290 300
GVGKNGSTIA GTSVLSPGLH IGLIIILAIM IYKKSATNVF EKHPCLYTLM
310 320 330 340 350
FGCVFAKVAQ KLVIAHMTKS ELYLQDTVFI GPGLLFLDQY FNNFIDEYVV
360 370 380 390
LWIAMVITSF DMMIYFSSLC LQISRHLHLS IFKTSYQQAP EQVHKHID
Length:398
Mass (Da):44,601
Last modified:October 11, 2004 - v1
Checksum:i9A6A12BD69E107D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082074 mRNA. Translation: AAH82074.1.
RefSeqiNP_001007751.1. NM_001007750.1.
UniGeneiRn.203263.

Genome annotation databases

EnsembliENSRNOT00000080939; ENSRNOP00000072444; ENSRNOG00000058271.
GeneIDi362866.
KEGGirno:362866.
UCSCiRGD:1359283. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082074 mRNA. Translation: AAH82074.1.
RefSeqiNP_001007751.1. NM_001007750.1.
UniGeneiRn.203263.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007305.

Proteomic databases

PaxDbiQ66H21.
PRIDEiQ66H21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080939; ENSRNOP00000072444; ENSRNOG00000058271.
GeneIDi362866.
KEGGirno:362866.
UCSCiRGD:1359283. rat.

Organism-specific databases

CTDi56994.
RGDi1359283. Chpt1.

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000230699.
HOVERGENiHBG107647.
InParanoidiQ66H21.
KOiK00994.
OMAiMAPNSIT.
OrthoDBiEOG091G07XY.
PhylomeDBiQ66H21.
TreeFamiTF313270.

Enzyme and pathway databases

UniPathwayiUPA00753; UER00740.
ReactomeiR-RNO-1483191. Synthesis of PC.

Miscellaneous databases

PROiQ66H21.

Gene expression databases

BgeeiENSRNOG00000005487.
GenevisibleiQ66H21. RN.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHPT1_RAT
AccessioniPrimary (citable) accession number: Q66H21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.