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Protein

Cholinephosphotransferase 1

Gene

Chpt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity).By similarity

Catalytic activityi

CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.

Cofactori

Mg2+By similarity, Mn2+By similarity

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Choline-phosphate cytidylyltransferase B (Pcyt1b), Choline-phosphate cytidylyltransferase A (Pcyt1a)
  2. Choline/ethanolaminephosphotransferase 1 (Cept1), Cholinephosphotransferase 1 (Chpt1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
UniPathwayiUPA00753; UER00740.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinephosphotransferase 1 (EC:2.7.8.2)
Alternative name(s):
Diacylglycerol cholinephosphotransferase 1
Gene namesi
Name:Chpt1
Synonyms:Cpt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359283. Chpt1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002892542 – 398Cholinephosphotransferase 1Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ66H21.
PRIDEiQ66H21.

Expressioni

Gene expression databases

BgeeiENSRNOG00000058271.
GenevisibleiQ66H21. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000230699.
HOVERGENiHBG107647.
InParanoidiQ66H21.
KOiK00994.
OMAiMAPNSIT.
OrthoDBiEOG091G07XY.
PhylomeDBiQ66H21.
TreeFamiTF313270.

Family and domain databases

InterProiView protein in InterPro
IPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiView protein in Pfam
PF01066. CDP-OH_P_transf. 1 hit.
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiView protein in PROSITE
PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66H21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGAGARPA PRWVKALGEP LSAAQLRRLE DHRYSAAGES LFEPPLQLFW
60 70 80 90 100
TWLLQWIPLW IAPNTITLFG LAINLFTTLV LIFYCPTVTE EAPYWTYLLC
110 120 130 140 150
ALGLFIYQSL DAIDGKQARR TNSCSPLGEL FDHGCDSLST VFMAIGASIA
160 170 180 190 200
VRLGTHPDWL FFCSFVGMFM FYCAHWQTYV SGVLRFGRVD VTEIQVALVI
210 220 230 240 250
VFLLSTFGGA MMWDYTIPIL EIKLKILPVL GVVGGLIFSC SNYFHVILHG
260 270 280 290 300
GVGKNGSTIA GTSVLSPGLH IGLIIILAIM IYKKSATNVF EKHPCLYTLM
310 320 330 340 350
FGCVFAKVAQ KLVIAHMTKS ELYLQDTVFI GPGLLFLDQY FNNFIDEYVV
360 370 380 390
LWIAMVITSF DMMIYFSSLC LQISRHLHLS IFKTSYQQAP EQVHKHID
Length:398
Mass (Da):44,601
Last modified:October 11, 2004 - v1
Checksum:i9A6A12BD69E107D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082074 mRNA. Translation: AAH82074.1.
RefSeqiNP_001007751.1. NM_001007750.1.
UniGeneiRn.203263.

Genome annotation databases

EnsembliENSRNOT00000080939; ENSRNOP00000072444; ENSRNOG00000058271.
GeneIDi362866.
KEGGirno:362866.
UCSCiRGD:1359283. rat.

Similar proteinsi

Entry informationi

Entry nameiCHPT1_RAT
AccessioniPrimary (citable) accession number: Q66H21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families