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Protein

Regulator of microtubule dynamics protein 3

Gene

Rmdn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of microtubule dynamics protein 3
Short name:
RMD-3
Alternative name(s):
Protein FAM82A2
Protein FAM82C
Gene namesi
Name:Rmdn3
Synonyms:Fam82a2, Fam82c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1308697. Rmdn3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 35HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875131 – 471Regulator of microtubule dynamics protein 3Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66H15.
PRIDEiQ66H15.

PTM databases

iPTMnetiQ66H15.
PhosphoSitePlusiQ66H15.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011690.
GenevisibleiQ66H15. RN.

Interactioni

Subunit structurei

Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016356.

Structurei

3D structure databases

ProteinModelPortaliQ66H15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 125Sequence analysisAdd BLAST35

Domaini

The transmembrane region is required for mitochondrial localization.By similarity

Sequence similaritiesi

Belongs to the RMDN family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRV. Eukaryota.
ENOG41101S6. LUCA.
GeneTreeiENSGT00530000063162.
HOGENOMiHOG000015374.
HOVERGENiHBG072518.
InParanoidiQ66H15.
OMAiEVRSHME.
OrthoDBiEOG091G0F3V.
PhylomeDBiQ66H15.
TreeFamiTF315854.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66H15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLGALGGS RAGLGLLLGT AAGLGFLCVL YSQRWKRTQR HGRSQSLPNS
60 70 80 90 100
LDYAQTSERG RQVTQLRAIP GEAGDAAMLS SLPQEGQEKV LDRLDFVLTS
110 120 130 140 150
LMALRREVEE LQRSLQGLAG EIVGEVRSHM EENQRVARRR RFPFARERSD
160 170 180 190 200
STGSSSVYFT ASSGATLTDA ESEGGYTTAN AESDYERDSD KESEDAEDEV
210 220 230 240 250
SCETVKMGRK DSLDLDMEVA SSPASAALED DDSSGLEDVQ LLLQQADELH
260 270 280 290 300
QGSEQNKQEG FQLLLNNKLA YGSRQDFLWR LARAYSDMTE LTEEESEKKS
310 320 330 340 350
YALNGKEEAE AALKKGDESA ASHLWYAVLC GQLAEHEGIS KRIQSGFSFK
360 370 380 390 400
EHVDKAIELQ PEDPRGHFLL GRWCYQVSHL SWLEKKTATA LFESPLSATV
410 420 430 440 450
QDALQSFLKA EELQPGFSKA GRVYISKCYR ELGKNSEARK WLNLAQELPN
460 470
ITNEDSAFQK DLEELEVILG K
Length:471
Mass (Da):52,312
Last modified:October 11, 2004 - v1
Checksum:i6B3FA1CF970F8C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082081 mRNA. Translation: AAH82081.1.
RefSeqiNP_001014068.1. NM_001014046.2.
UniGeneiRn.18772.

Genome annotation databases

EnsembliENSRNOT00000016356; ENSRNOP00000016356; ENSRNOG00000011690.
GeneIDi311328.
KEGGirno:311328.
UCSCiRGD:1308697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082081 mRNA. Translation: AAH82081.1.
RefSeqiNP_001014068.1. NM_001014046.2.
UniGeneiRn.18772.

3D structure databases

ProteinModelPortaliQ66H15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016356.

PTM databases

iPTMnetiQ66H15.
PhosphoSitePlusiQ66H15.

Proteomic databases

PaxDbiQ66H15.
PRIDEiQ66H15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016356; ENSRNOP00000016356; ENSRNOG00000011690.
GeneIDi311328.
KEGGirno:311328.
UCSCiRGD:1308697. rat.

Organism-specific databases

CTDi55177.
RGDi1308697. Rmdn3.

Phylogenomic databases

eggNOGiENOG410IFRV. Eukaryota.
ENOG41101S6. LUCA.
GeneTreeiENSGT00530000063162.
HOGENOMiHOG000015374.
HOVERGENiHBG072518.
InParanoidiQ66H15.
OMAiEVRSHME.
OrthoDBiEOG091G0F3V.
PhylomeDBiQ66H15.
TreeFamiTF315854.

Miscellaneous databases

PROiQ66H15.

Gene expression databases

BgeeiENSRNOG00000011690.
GenevisibleiQ66H15. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRMD3_RAT
AccessioniPrimary (citable) accession number: Q66H15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.