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Protein

F-box only protein 39

Gene

Fbxo39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 39
Gene namesi
Name:Fbxo39
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1311464. Fbxo39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443F-box only protein 39PRO_0000119937Add
BLAST

Proteomic databases

PaxDbiQ66H10.
PRIDEiQ66H10.

Expressioni

Gene expression databases

GenevisibleiQ66H10. RN.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020071.

Structurei

3D structure databases

ProteinModelPortaliQ66H10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 5947F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ66H10.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG77M8P0.
PhylomeDBiQ66H10.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66H10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDSEVTQP QDQSCWATLP DVCLRRVFWW LGDRDRSRAA LVCRKWNQIM
60 70 80 90 100
YSADLWRYRT ITFSGRPSRV HASEFESALW YVKKFGRYLE HLEIKFLNPY
110 120 130 140 150
NAVLTKKFQV TMRGLLSCLG KSNNRLRSLS IQHLELDRLV WRNSIRGSLI
160 170 180 190 200
KSLSFFLKKM GKHLDHLSLK GARLTVEQGC HILNSLSYMR NENVASELNI
210 220 230 240 250
EDFFSHHLAV YGSSQFNKAM ATFHNLTFLT LNYNCISDEL LETLSENNAG
260 270 280 290 300
TLRTMNIKCH VHDPHGQVVW GMSWAKLARQ ASNLKVNFFF ERVMKYERLA
310 320 330 340 350
RILLQEIPVR SISLRSCYFS DPDWSMRPTL TDLLPTFRNT LQKLTFEFNN
360 370 380 390 400
NHESLDEQLH LLILACRKLF YFKIWAFLDV KFVERILKSQ EEGQCSLRTL
410 420 430 440
KVRIYTNRYE TNEEDRTLRE IYRKYRKLID SELNYFVIAY PMM
Length:443
Mass (Da):52,504
Last modified:March 15, 2005 - v2
Checksum:i0A164BAC55B4B97F
GO

Sequence cautioni

The sequence AAH82089.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082089 mRNA. Translation: AAH82089.1. Sequence problems.
BC100079 mRNA. Translation: AAI00080.1.
RefSeqiNP_001034107.1. NM_001039018.1.
XP_006246789.1. XM_006246727.2.
XP_006246791.1. XM_006246729.2.
UniGeneiRn.198886.

Genome annotation databases

EnsembliENSRNOT00000020071; ENSRNOP00000020071; ENSRNOG00000014953.
GeneIDi303287.
KEGGirno:303287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082089 mRNA. Translation: AAH82089.1. Sequence problems.
BC100079 mRNA. Translation: AAI00080.1.
RefSeqiNP_001034107.1. NM_001039018.1.
XP_006246789.1. XM_006246727.2.
XP_006246791.1. XM_006246729.2.
UniGeneiRn.198886.

3D structure databases

ProteinModelPortaliQ66H10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020071.

Proteomic databases

PaxDbiQ66H10.
PRIDEiQ66H10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020071; ENSRNOP00000020071; ENSRNOG00000014953.
GeneIDi303287.
KEGGirno:303287.

Organism-specific databases

CTDi162517.
RGDi1311464. Fbxo39.

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ66H10.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG77M8P0.
PhylomeDBiQ66H10.
TreeFamiTF321665.

Miscellaneous databases

NextBioi651056.
PROiQ66H10.

Gene expression databases

GenevisibleiQ66H10. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFBX39_RAT
AccessioniPrimary (citable) accession number: Q66H10
Secondary accession number(s): Q498T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.