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Q66GQ3

- PDI16_ARATH

UniProt

Q66GQ3 - PDI16_ARATH

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Protein

Protein disulfide isomerase-like 1-6

Gene
PDIL1-6, PDI4, PDIL3-2, At3g16110, MSL1.15
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Nucleophile By similarity
Active sitei446 – 4461Nucleophile By similarity
Active sitei449 – 4491Nucleophile By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: TAIR

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciARA:AT3G16110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-6 (EC:5.3.4.1)
Short name:
AtPDIL1-6
Alternative name(s):
Protein disulfide isomerase 4
Short name:
AtPDI4
Protein disulfide isomerase-like 3-2
Short name:
AtPDIL3-2
Gene namesi
Name:PDIL1-6
Synonyms:PDI4, PDIL3-2
Ordered Locus Names:At3g16110
ORF Names:MSL1.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G16110.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 534504Protein disulfide isomerase-like 1-6PRO_0000400021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi446 ↔ 449Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ66GQ3.
PRIDEiQ66GQ3.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevestigatoriQ66GQ3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16110.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ66GQ3.
SMRiQ66GQ3. Positions 77-526.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 182127Thioredoxin 1Add
BLAST
Domaini407 – 524118Thioredoxin 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi531 – 5344Prevents secretion from ER By similarity

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000241706.
InParanoidiQ66GQ3.
KOiK09580.
OMAiPWCINCE.
PhylomeDBiQ66GQ3.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66GQ3-1 [UniParc]FASTAAdd to Basket

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MLTKPKPNSK FSILFTFLLL LSFLIFVARS SDVAVEAGSE EELDDLEQLL    50
AVDEQLQEER PEQQSEAETV SKAQRIVVEL NGDNTKRLID GNEYVMVLGY 100
APWCARSAEL MPRFAEAATD LKEIGSSVLM AKIDGERYSK VASQLEIKGF 150
PTLLLFVNGT SQSYTGGFSS EEIVIWVQKK TGASTIKLDT VDEASGFLKK 200
HHTFILGLFE KSEDSSGHDE FVKAASLDNE IQFVETSSID VAKLLFPNLK 250
TNNVFVGLVK TEAEKYTSYD GPCQAEKIVE FLNSNKFPLV TKLTESNTVR 300
VYSSPVKLQV MVFSKTDDFE SLAQPLEDIA RKFKSKLMLI YIDISNENLA 350
MPFLTLFGIE DAKKTVVAAF DNNLNSKYLL ESDPSPSNIE EFCFGLAHGT 400
VSAYYKSQPI PDNQNASVVA VVGRTFDEVV LRSSENVLLE VHTPWCINCE 450
ALSKQVEKLS QHFKGFENLV FARIDASANE HPKLTVDDYP TILLYKTGEK 500
ENPLKLSTKS SAKDMAVLIN KELKWKDQSG KDEL 534
Length:534
Mass (Da):59,571
Last modified:October 11, 2004 - v1
Checksum:i66FA90F57CF5FF85
GO

Sequence cautioni

The sequence BAB02677.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3261L → P in BAD94313. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012247 Genomic DNA. Translation: BAB02677.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75772.1.
BT015349 mRNA. Translation: AAU05472.1.
BT015798 mRNA. Translation: AAU93570.1.
AK221388 mRNA. Translation: BAD94313.1.
RefSeqiNP_188232.2. NM_112481.3.
UniGeneiAt.50187.

Genome annotation databases

EnsemblPlantsiAT3G16110.1; AT3G16110.1; AT3G16110.
GeneIDi820856.
KEGGiath:AT3G16110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012247 Genomic DNA. Translation: BAB02677.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE75772.1 .
BT015349 mRNA. Translation: AAU05472.1 .
BT015798 mRNA. Translation: AAU93570.1 .
AK221388 mRNA. Translation: BAD94313.1 .
RefSeqi NP_188232.2. NM_112481.3.
UniGenei At.50187.

3D structure databases

ProteinModelPortali Q66GQ3.
SMRi Q66GQ3. Positions 77-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G16110.1-P.

Proteomic databases

PaxDbi Q66GQ3.
PRIDEi Q66GQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G16110.1 ; AT3G16110.1 ; AT3G16110 .
GeneIDi 820856.
KEGGi ath:AT3G16110.

Organism-specific databases

TAIRi AT3G16110.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000241706.
InParanoidi Q66GQ3.
KOi K09580.
OMAi PWCINCE.
PhylomeDBi Q66GQ3.

Enzyme and pathway databases

BioCyci ARA:AT3G16110-MONOMER.

Gene expression databases

Genevestigatori Q66GQ3.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
    Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
    Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
    Lu D.-P., Christopher D.A.
    Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
    d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
    BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPDI16_ARATH
AccessioniPrimary (citable) accession number: Q66GQ3
Secondary accession number(s): Q56YD5, Q9LW75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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