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Q66GQ3 (PDI16_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide isomerase-like 1-6

Short name=AtPDIL1-6
EC=5.3.4.1
Alternative name(s):
Protein disulfide isomerase 4
Short name=AtPDI4
Protein disulfide isomerase-like 3-2
Short name=AtPDIL3-2
Gene names
Name:PDIL1-6
Synonyms:PDI4, PDIL3-2
Ordered Locus Names:At3g16110
ORF Names:MSL1.15
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds By similarity.

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen Probable.

Tissue specificity

Widely expressed. Ref.6

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence caution

The sequence BAB02677.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 534504Protein disulfide isomerase-like 1-6
PRO_0000400021

Regions

Domain56 – 182127Thioredoxin 1
Domain407 – 524118Thioredoxin 2
Motif531 – 5344Prevents secretion from ER By similarity

Sites

Active site1041Nucleophile By similarity
Active site4461Nucleophile By similarity
Active site4491Nucleophile By similarity

Amino acid modifications

Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Disulfide bond446 ↔ 449Redox-active By similarity

Experimental info

Sequence conflict3261L → P in BAD94313. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q66GQ3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 66FA90F57CF5FF85

FASTA53459,571
        10         20         30         40         50         60 
MLTKPKPNSK FSILFTFLLL LSFLIFVARS SDVAVEAGSE EELDDLEQLL AVDEQLQEER 

        70         80         90        100        110        120 
PEQQSEAETV SKAQRIVVEL NGDNTKRLID GNEYVMVLGY APWCARSAEL MPRFAEAATD 

       130        140        150        160        170        180 
LKEIGSSVLM AKIDGERYSK VASQLEIKGF PTLLLFVNGT SQSYTGGFSS EEIVIWVQKK 

       190        200        210        220        230        240 
TGASTIKLDT VDEASGFLKK HHTFILGLFE KSEDSSGHDE FVKAASLDNE IQFVETSSID 

       250        260        270        280        290        300 
VAKLLFPNLK TNNVFVGLVK TEAEKYTSYD GPCQAEKIVE FLNSNKFPLV TKLTESNTVR 

       310        320        330        340        350        360 
VYSSPVKLQV MVFSKTDDFE SLAQPLEDIA RKFKSKLMLI YIDISNENLA MPFLTLFGIE 

       370        380        390        400        410        420 
DAKKTVVAAF DNNLNSKYLL ESDPSPSNIE EFCFGLAHGT VSAYYKSQPI PDNQNASVVA 

       430        440        450        460        470        480 
VVGRTFDEVV LRSSENVLLE VHTPWCINCE ALSKQVEKLS QHFKGFENLV FARIDASANE 

       490        500        510        520        530 
HPKLTVDDYP TILLYKTGEK ENPLKLSTKS SAKDMAVLIN KELKWKDQSG KDEL 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[6]"Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
Lu D.-P., Christopher D.A.
Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB012247 Genomic DNA. Translation: BAB02677.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75772.1.
BT015349 mRNA. Translation: AAU05472.1.
BT015798 mRNA. Translation: AAU93570.1.
AK221388 mRNA. Translation: BAD94313.1.
RefSeqNP_188232.2. NM_112481.3.
UniGeneAt.50187.

3D structure databases

ProteinModelPortalQ66GQ3.
SMRQ66GQ3. Positions 77-530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT3G16110.1-P.

Proteomic databases

PaxDbQ66GQ3.
PRIDEQ66GQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G16110.1; AT3G16110.1; AT3G16110.
GeneID820856.
KEGGath:AT3G16110.

Organism-specific databases

TAIRAT3G16110.

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000241706.
InParanoidQ66GQ3.
KOK09580.
OMANEIQFVE.
PhylomeDBQ66GQ3.
ProtClustDBCLSN2680753.

Enzyme and pathway databases

BioCycARA:AT3G16110-MONOMER.

Gene expression databases

GenevestigatorQ66GQ3.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 4 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDI16_ARATH
AccessionPrimary (citable) accession number: Q66GQ3
Secondary accession number(s): Q56YD5, Q9LW75
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names