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Protein

Protein disulfide isomerase-like 1-6

Gene

PDIL1-6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104NucleophileBy similarity1
Active sitei446NucleophileBy similarity1
Active sitei449NucleophileBy similarity1

GO - Molecular functioni

  • protein disulfide isomerase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-6 (EC:5.3.4.1)
Short name:
AtPDIL1-6
Alternative name(s):
Protein disulfide isomerase 4
Short name:
AtPDI4
Protein disulfide isomerase-like 3-2
Short name:
AtPDIL3-2
Gene namesi
Name:PDIL1-6
Synonyms:PDI4, PDIL3-2
Ordered Locus Names:At3g16110
ORF Names:MSL1.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G16110.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000040002131 – 534Protein disulfide isomerase-like 1-6Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi446 ↔ 449Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ66GQ3.

PTM databases

iPTMnetiQ66GQ3.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevisibleiQ66GQ3. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16110.1.

Structurei

3D structure databases

ProteinModelPortaliQ66GQ3.
SMRiQ66GQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 182Thioredoxin 1PROSITE-ProRule annotationAdd BLAST127
Domaini407 – 524Thioredoxin 2PROSITE-ProRule annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 534Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000241706.
InParanoidiQ66GQ3.
KOiK09580.
OMAiKDMAKFI.
OrthoDBiEOG093608OJ.
PhylomeDBiQ66GQ3.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66GQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKPKPNSK FSILFTFLLL LSFLIFVARS SDVAVEAGSE EELDDLEQLL
60 70 80 90 100
AVDEQLQEER PEQQSEAETV SKAQRIVVEL NGDNTKRLID GNEYVMVLGY
110 120 130 140 150
APWCARSAEL MPRFAEAATD LKEIGSSVLM AKIDGERYSK VASQLEIKGF
160 170 180 190 200
PTLLLFVNGT SQSYTGGFSS EEIVIWVQKK TGASTIKLDT VDEASGFLKK
210 220 230 240 250
HHTFILGLFE KSEDSSGHDE FVKAASLDNE IQFVETSSID VAKLLFPNLK
260 270 280 290 300
TNNVFVGLVK TEAEKYTSYD GPCQAEKIVE FLNSNKFPLV TKLTESNTVR
310 320 330 340 350
VYSSPVKLQV MVFSKTDDFE SLAQPLEDIA RKFKSKLMLI YIDISNENLA
360 370 380 390 400
MPFLTLFGIE DAKKTVVAAF DNNLNSKYLL ESDPSPSNIE EFCFGLAHGT
410 420 430 440 450
VSAYYKSQPI PDNQNASVVA VVGRTFDEVV LRSSENVLLE VHTPWCINCE
460 470 480 490 500
ALSKQVEKLS QHFKGFENLV FARIDASANE HPKLTVDDYP TILLYKTGEK
510 520 530
ENPLKLSTKS SAKDMAVLIN KELKWKDQSG KDEL
Length:534
Mass (Da):59,571
Last modified:October 11, 2004 - v1
Checksum:i66FA90F57CF5FF85
GO

Sequence cautioni

The sequence BAB02677 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326L → P in BAD94313 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012247 Genomic DNA. Translation: BAB02677.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75772.1.
BT015349 mRNA. Translation: AAU05472.1.
BT015798 mRNA. Translation: AAU93570.1.
AK221388 mRNA. Translation: BAD94313.1.
RefSeqiNP_188232.2. NM_112481.4.
UniGeneiAt.50187.

Genome annotation databases

EnsemblPlantsiAT3G16110.1; AT3G16110.1; AT3G16110.
GeneIDi820856.
GrameneiAT3G16110.1; AT3G16110.1; AT3G16110.
KEGGiath:AT3G16110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012247 Genomic DNA. Translation: BAB02677.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75772.1.
BT015349 mRNA. Translation: AAU05472.1.
BT015798 mRNA. Translation: AAU93570.1.
AK221388 mRNA. Translation: BAD94313.1.
RefSeqiNP_188232.2. NM_112481.4.
UniGeneiAt.50187.

3D structure databases

ProteinModelPortaliQ66GQ3.
SMRiQ66GQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G16110.1.

PTM databases

iPTMnetiQ66GQ3.

Proteomic databases

PaxDbiQ66GQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G16110.1; AT3G16110.1; AT3G16110.
GeneIDi820856.
GrameneiAT3G16110.1; AT3G16110.1; AT3G16110.
KEGGiath:AT3G16110.

Organism-specific databases

TAIRiAT3G16110.

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000241706.
InParanoidiQ66GQ3.
KOiK09580.
OMAiKDMAKFI.
OrthoDBiEOG093608OJ.
PhylomeDBiQ66GQ3.

Miscellaneous databases

PROiQ66GQ3.

Gene expression databases

GenevisibleiQ66GQ3. AT.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDI16_ARATH
AccessioniPrimary (citable) accession number: Q66GQ3
Secondary accession number(s): Q56YD5, Q9LW75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.