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Q66GQ3

- PDI16_ARATH

UniProt

Q66GQ3 - PDI16_ARATH

Protein

Protein disulfide isomerase-like 1-6

Gene

PDIL1-6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041NucleophileBy similarity
    Active sitei446 – 4461NucleophileBy similarity
    Active sitei449 – 4491NucleophileBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: TAIR

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: GOC

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciARA:AT3G16110-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide isomerase-like 1-6 (EC:5.3.4.1)
    Short name:
    AtPDIL1-6
    Alternative name(s):
    Protein disulfide isomerase 4
    Short name:
    AtPDI4
    Protein disulfide isomerase-like 3-2
    Short name:
    AtPDIL3-2
    Gene namesi
    Name:PDIL1-6
    Synonyms:PDI4, PDIL3-2
    Ordered Locus Names:At3g16110
    ORF Names:MSL1.15
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G16110.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: TAIR
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 534504Protein disulfide isomerase-like 1-6PRO_0000400021Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi446 ↔ 449Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ66GQ3.
    PRIDEiQ66GQ3.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    GenevestigatoriQ66GQ3.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G16110.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66GQ3.
    SMRiQ66GQ3. Positions 77-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 182127Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini407 – 524118Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi531 – 5344Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000241706.
    InParanoidiQ66GQ3.
    KOiK09580.
    OMAiPWCINCE.
    PhylomeDBiQ66GQ3.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q66GQ3-1 [UniParc]FASTAAdd to Basket

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    MLTKPKPNSK FSILFTFLLL LSFLIFVARS SDVAVEAGSE EELDDLEQLL    50
    AVDEQLQEER PEQQSEAETV SKAQRIVVEL NGDNTKRLID GNEYVMVLGY 100
    APWCARSAEL MPRFAEAATD LKEIGSSVLM AKIDGERYSK VASQLEIKGF 150
    PTLLLFVNGT SQSYTGGFSS EEIVIWVQKK TGASTIKLDT VDEASGFLKK 200
    HHTFILGLFE KSEDSSGHDE FVKAASLDNE IQFVETSSID VAKLLFPNLK 250
    TNNVFVGLVK TEAEKYTSYD GPCQAEKIVE FLNSNKFPLV TKLTESNTVR 300
    VYSSPVKLQV MVFSKTDDFE SLAQPLEDIA RKFKSKLMLI YIDISNENLA 350
    MPFLTLFGIE DAKKTVVAAF DNNLNSKYLL ESDPSPSNIE EFCFGLAHGT 400
    VSAYYKSQPI PDNQNASVVA VVGRTFDEVV LRSSENVLLE VHTPWCINCE 450
    ALSKQVEKLS QHFKGFENLV FARIDASANE HPKLTVDDYP TILLYKTGEK 500
    ENPLKLSTKS SAKDMAVLIN KELKWKDQSG KDEL 534
    Length:534
    Mass (Da):59,571
    Last modified:October 11, 2004 - v1
    Checksum:i66FA90F57CF5FF85
    GO

    Sequence cautioni

    The sequence BAB02677.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti326 – 3261L → P in BAD94313. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012247 Genomic DNA. Translation: BAB02677.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE75772.1.
    BT015349 mRNA. Translation: AAU05472.1.
    BT015798 mRNA. Translation: AAU93570.1.
    AK221388 mRNA. Translation: BAD94313.1.
    RefSeqiNP_188232.2. NM_112481.3.
    UniGeneiAt.50187.

    Genome annotation databases

    EnsemblPlantsiAT3G16110.1; AT3G16110.1; AT3G16110.
    GeneIDi820856.
    KEGGiath:AT3G16110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012247 Genomic DNA. Translation: BAB02677.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE75772.1 .
    BT015349 mRNA. Translation: AAU05472.1 .
    BT015798 mRNA. Translation: AAU93570.1 .
    AK221388 mRNA. Translation: BAD94313.1 .
    RefSeqi NP_188232.2. NM_112481.3.
    UniGenei At.50187.

    3D structure databases

    ProteinModelPortali Q66GQ3.
    SMRi Q66GQ3. Positions 77-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G16110.1-P.

    Proteomic databases

    PaxDbi Q66GQ3.
    PRIDEi Q66GQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G16110.1 ; AT3G16110.1 ; AT3G16110 .
    GeneIDi 820856.
    KEGGi ath:AT3G16110.

    Organism-specific databases

    TAIRi AT3G16110.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000241706.
    InParanoidi Q66GQ3.
    KOi K09580.
    OMAi PWCINCE.
    PhylomeDBi Q66GQ3.

    Enzyme and pathway databases

    BioCyci ARA:AT3G16110-MONOMER.

    Gene expression databases

    Genevestigatori Q66GQ3.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
      Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
      Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    6. "Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana."
      Lu D.-P., Christopher D.A.
      Mol. Genet. Genomics 280:199-210(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
      d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
      BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPDI16_ARATH
    AccessioniPrimary (citable) accession number: Q66GQ3
    Secondary accession number(s): Q56YD5, Q9LW75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3